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A Randomized Pilot Study of Atractylenolide I on Gastric Cancer Cachexia Patients

We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) and proteolysis-inducing factor (PIF). This was a randomized but not...

A Randomized Pilot Study of Atractylenolide I on Gastric Cancer Cachexia Patients

We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) and proteolysis-inducing factor (PIF). This was a randomized but not...

Catalytic oxidative desulfurization of fuels in acidic deep eutectic solvents with [(C6H13)3P(C14H29)]3PMo12O40 as a catalyst

Deep eutectic solvents (DESs) are a new class of green solvents analogous to ionic liquids due to their biodegradable capacity and low cost. However, the direct extractive desulfurization of diesel oil by DESs cannot meet the government’s standard. In this work, amphiphilic polyoxometalates were synthesized and characterized by FT-IR and mass spectrometry. The oxidative...

Readout Distance Enhancement of the Passive Wireless Multi-Parameter Sensing System Using a Repeater Coil

A repeater coil is used to extend the detection distance of a passive wireless multi-parameter sensing system. The passive wireless sensing system has the ability of simultaneously monitoring three parameters by using backscatter modulation together with channel multiplexing. Two different repeater coils are designed and fabricated for readout distance enhancement of the sensing...

Readout Distance Enhancement of the Passive Wireless Multi-Parameter Sensing System Using a Repeater Coil

A repeater coil is used to extend the detection distance of a passive wireless multi-parameter sensing system. The passive wireless sensing system has the ability of simultaneously monitoring three parameters by using backscatter modulation together with channel multiplexing. Two different repeater coils are designed and fabricated for readout distance enhancement of the sensing...

Measuring economic activity in China with mobile big data

Emerging trends in the use of smartphones, online mapping applications, and social media, in addition to the geo-located data they generate, provide opportunities to trace users’ socio-economic activities in an unprecedentedly granular and direct fashion and have triggered a revolution in empirical research. These vast mobile data offer new perspectives and approaches to measure...

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection Li-Juan Zhi,1,2,* Li Wang,2,3,* Xing-Kai Chen,4 Xiao-Ying Zhai,3 Li Wen,3 Lei Dong,1,2

Population-weighted efficiency in transportation networks

Transportation efficiency is critical for the operation of cities and is attracting great attention worldwide. Improving the transportation efficiency can not only decrease energy consumption, reduce carbon emissions, but also accelerate people’s interactions, which will become more and more important for sustainable urban living. Generally, traffic conditions in less-developed...

Influence of Content of Al2O3 on Structure and Properties of Nanocomposite Nb-B-Al-O films

Nb-B-Al-O nanocomposite films with different power of Al2O3 were successfully deposited on the Si substrate via multi-target magnetron co-sputtering method. The influences of Al2O3’s content on structure and properties of obtained nanocomposite films through controlling Al2O3’s power were investigated. Increasing the power of Al2O3 can influence the bombarding energy and cause...

Beat frequency quartz-enhanced photoacoustic spectroscopy for fast and calibration-free continuous trace-gas monitoring

acknowledges Grant C-0586 by the Welch Foundation. Author information Author notesHongpeng Wu & Lei Dong These authors contributed equally to this work AffiliationsState Key Laboratory of Quantum Optics and ... Quantum Optics Devices, Institute of Laser Spectroscopy, Shanxi University, Taiyuan 030006, ChinaHongpeng Wu, Lei Dong, Huadan Zheng, Weiguang Ma, Lei Zhang, Wangbao Yin, Liantuan Xiao & Suotang

High light stress triggers distinct proteomic responses in the marine diatom Thalassiosira pseudonana

Background Diatoms are able to acclimate to frequent and large light fluctuations in the surface ocean waters. However, the molecular mechanisms underlying these acclimation responses of diaotms remain elusive. Results In this study, we investigated the mechanism of high light protection in marine diatom Thalassiosira pseudonana using comparative proteomics in combination with...

High light stress triggers distinct proteomic responses in the marine diatom Thalassiosira pseudonana

Background Diatoms are able to acclimate to frequent and large light fluctuations in the surface ocean waters. However, the molecular mechanisms underlying these acclimation responses of diaotms remain elusive. Results In this study, we investigated the mechanism of high light protection in marine diatom Thalassiosira pseudonana using comparative proteomics in combination with...

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

The mitochondrial GTPase mitofusin-2 (MFN2) has previously been reported to play a role in regulating cell proliferation, apoptosis and differentiation in a number of cell types. Here, we report that breast cancer patients with low MFN2 expression are associated with poor prognosis as compared to patients with high MFN2 expression. We find that MFN2 knockout from MCF7 and A549...

Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells

Professor Hao Xi from Shanghai Tenth People?s Hospital, Shanghai, for providing pancreatic cancer samples. They would like to sincerely thank Lao I. Weng and Lei Dong from Department of Pathology, Shanghai

Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy

for Lei Dong in:Nature Research journals • PubMed • Google Scholar Contributions L.D., J.Z. and C.W. designed the experiments; L.D. and C.W. wrote the main text. Q.Z., H.Q., Z.L., S.L. and Z.H ... . conducted the experiments and prepared the figures. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Junfeng Zhang or Chunming Wang or Lei Dong

MYC cis-Elements in PsMPT Promoter Is Involved in Chilling Response of Paeonia suffruticosa

The MPT transports Pi to synthesize ATP. PsMPT, a chilling-induced gene, was previously reported to promote energy metabolism during bud dormancy release in tree peony. In this study, the regulatory elements of PsMPT promoter involved in chilling response were further analyzed. The PsMPT transcript was detected in different tree peony tissues and was highly expressed in the...

Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression

Background Hepatocellular carcinoma (HCC) is the most common type of tumor and is associated with high morbidity and mortality rates. Patients with HCC routinely undergo surgery followed by adjuvant radiation therapy and chemotherapy. Despite such aggressive treatment approaches, median survival times remain under 1 year in most cases. KDM5C is a member of the family of JmjC...

Multi-Quartz Enhanced Photoacoustic Spectroscopy with Different Acoustic Microresonator Configurations

Acoustic microresonators were added to the recently developed multi-QTF based QEPAS spectrophone to enhance the signal amplitude. Two kinds of “on-beam“ configurations were experimentally investigated in detail. The developed multi-QTF based “on-beam“ spectrophone had a signal enhancement of 1.6 times compared with the traditional single QTF based “on-beam“ spectrophone, with the...

Multi-Quartz Enhanced Photoacoustic Spectroscopy with Different Acoustic Microresonator Configurations

Acoustic microresonators were added to the recently developed multi-QTF based QEPAS spectrophone to enhance the signal amplitude. Two kinds of “on-beam“ configurations were experimentally investigated in detail. The developed multi-QTF based “on-beam“ spectrophone had a signal enhancement of 1.6 times compared with the traditional single QTF based “on-beam“ spectrophone, with the...