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Effective weight control via an implanted self-powered vagus nerve stimulation device

In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted vagus nerve stimulation system that is battery-free and spontaneously responsive to stomach movement. The vagus nerve stimulation system comprises a flexible and biocompatible nanogenerator that is attached on the surface of stomach. It generates...

A Novel Nanocone Cluster Microstructure with Anti-reflection and Superhydrophobic Properties for Photovoltaic Devices

As three-dimensional (3D) nanostructures can significantly improve the absorption capacity of photons, it is widely used in various photovoltaic devices. However, the high-cost and complex preparation process of traditional 3D nanostructures restricted its development greatly. In this paper, a new type of nanocone cluster microstructure was prepared on polydimethylsiloxane (PDMS...

Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis

Osteoarthritis (OA) has been recognized as the most common chronic age-related disease. Cartilage degeneration influences OA therapy. Here we report that hematopoietic pre-B cell leukemia transcription factor-interacting protein (HPIP) is essential for OA development. Elevated HPIP levels are found in OA patients. Col2a1-CreERT2/HPIPf/f mice exhibit obvious skeletal abnormalities...

Conformal metasurface-coated dielectric waveguides for highly confined broadband optical activity with simultaneous low-visibility and reduced crosstalk

in:Nature Research journals • PubMed • Google Scholar Search for Lei Kang in:Nature Research journals • PubMed • Google Scholar Search for Douglas H. Werner in:Nature Research journals • PubMed • Google ... discussions during the preparation of the manuscript. Author information AffiliationsDepartment of Electrical Engineering, The Pennsylvania State University, University Park, PA, 16802, USAZhi Hao Jiang, Lei

Efficient Cross-talk Reduction of Nanophotonic Circuits Enabled by Fabrication Friendly Periodic Silicon Strip Arrays

Engineering, The Pennsylvania State University University Park, PA, 16802, USAYusheng Bian, Lei Kang, Yifeng Qin, Pingjuan L. Werner & Douglas H. WernerSchool of Electronics and Information Engineering, Beihang ... Search for Lei Kang in:Nature Research journals • PubMed • Google Scholar Search for Yifeng Qin in:Nature Research journals • PubMed • Google Scholar Search for Pingjuan L. Werner in:Nature Research

Development Situation, Trend and Countermeasure of Consumer-level UAV Market in China

ITM Web of Conferences Development Situation, Trend and Consumer-level UAV Market in China Yu-Lei KANG 0 Yang XI 0 0 Beijing Institute of Fashion Technology, Business School , China This paper is

Efficient Wideband Numerical Simulations for Nanostructures Employing a Drude-Critical Points (DCP) Dispersive Model

A highly efficient numerical approach for simulating the wideband optical response of nano-architectures comprised of Drude-Critical Points (DCP) media (e.g., gold and silver) is proposed and validated through comparing with commercial computational software. The kernel of this algorithm is the subdomain level discontinuous Galerkin time domain (DGTD) method, which can be viewed...

Hybrid metamaterials for electrically triggered multifunctional control

Campbell for discussions on the data and their interpretation. Author information Author notesLiu Liu & Lei Kang These authors contributed equally to this work Theresa S. Mayer Present address ... Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USALiu Liu, Lei Kang, Theresa S. Mayer & Douglas H. Werner AuthorsSearch for Liu Liu in:Nature Research journals • PubMed

Intensity-dependent modulation of optically active signals in a chiral metamaterial

Chiral media exhibit optical phenomena that provide distinctive responses from opposite circular polarizations. The disparity between these responses can be optimized by structurally engineering absorptive materials into chiral nanopatterns to form metamaterials that provide gigantic chiroptical resonances. To fully leverage the innate duality of chiral metamaterials for future...

Handedness Dependent Electromagnetically Induced Transparency in Hybrid Chiral Metamaterials

AffiliationsDepartment of Electrical Engineering, The Pennsylvania State University, University Park, PA, 16802 USALei Kang, Zhi Hao Jiang, Taiwei Yue & Douglas H. Werner AuthorsSearch for Lei Kang in:Nature Research

A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage

Li lei Kang Nini An Fei Li Ping Lin Lugang Huang OPEN Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1?) plays an important role in this process. A ... Li and Lei Kang; data analysis and interpretation: Jie Zhang, Jun Li, Kai Li, Jie Zhang, Lugang Huang and Ping Lin; Drafting the manuscript: Jie Zhang and Ping Lin; administrative, technical, or

Transcriptomic Analysis Reveals Differential Gene Expressions for Cell Growth and Functional Secondary Metabolites in Induced Autotetraploid of Chinese Woad (Isatis indigotica Fort.)

The giant organs and enhanced concentrations of secondary metabolites realized by autopolyploidy are attractive for breeding the respective medicinal and agricultural plants and studying the genetic mechanisms. The traditional medicinal plant Chinese woad (Isatis indigotica Fort., 2n = 2x = 14) is now still largely used for the diseases caused by bacteria and viruses in China. In...

HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion

ScholarSearch for Xiaopeng Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Zhe Wu in:Nature Research journals • PubMed • Google ScholarSearch for Lei Kang in:Nature Research journals

PolyC-Binding Protein 1 Interacts with 5′-Untranslated Region of Enterovirus 71 RNA in Membrane-Associated Complex to Facilitate Viral Replication

Enterovirus 71 (EV71) is one causative agent of hand, foot, and mouth disease (HFMD), which may lead to severe neurological disorders and mortality in children. EV71 genome is a positive single-stranded RNA containing a single open reading frame (ORF) flanked by 5′-untranslated region (5′UTR) and 3′UTR. The 5′UTR is fundamentally important for virus replication by interacting...

An Experimental Study on 131I-CHIBA-1001: A Radioligand for α7 Nicotinic Acetylcholine Receptors

Objective The α7 nicotinic acetylcholine receptors (nAChRs) play a vital role in the pathophysiology of neuropsychiatric diseases such as Alzheimer’s disease and depression. However, there is currently no suitable positron emission tomography (PET) or Single-Photon Emission Computed Tomography (SPECT) radioligands for imaging α7 nAChRs in brain. Here our aim is to radiosynthesize...

Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection

BackgroundInterleukin (IL)-32 is a recently described pro-inflammatory cytokine that has been reported to be induced by bacteria treatment in culture cells. Little is known about IL-32 production by exogenous pathogens infection in human individuals.Methods and FindingsIn this study, we found that IL-32 level was increased by 58.2% in the serum samples from a cohort of 108...