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The Expression Patterns and Associated Clinical Parameters of Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 and Transmembrane and Immunoglobulin Domain Containing 2 in Oral Squamous Cell Carcinoma

Squamous Cell Carcinoma Yao Xiao,1 Hao Li,1 Lei-Lei Yang,1 Liang Mao,1 Cong-Cong Wu,1 Wen-Feng Zhang,2 and Zhi-Jun Sun1,2 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST

Event Detection and Multi-source Propagation for Online Social Network Management

) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Authors and Affiliations Lei-lei Shi1Lu Liu2Email authorYan Wu1Liang Jiang1Ayodeji Ayorinde31.School

Two New Eudesmane Sesquiterpenoids from the Flowers of Chrysanthemum indicum

The flowers of Chrysanthemum indicum, i.e. Ye-ju-hua recorded in the Chinese Pharmacopoeia, has been widely used in China as an important heat-clearing and detoxifying herb for the treatment of inflammation, headache, and vertigo. A phytochemical investigation of this herb has led to the isolation of two new eudesmane sesquiterpenoids, 7-epi-eudesm-4(15),11(13)-diene-1β,3β-diol...

PRDM16 functions as a suppressor of lung adenocarcinoma metastasis

The transcription factor PR domain containing 16 (PRDM16) is known to play a significant role in the determination and function of brown and beige fat. However, the role of PRDM16 in tumor biology has not been well addressed. Here we investigated the impact of PRDM16 on tumor growth and metastasis in lung cancer. UALCAN database, immunoblotting and immunohistochemistry analysis...

Coupled Resonance Enhanced Modulation for a Graphene-Loaded Metamaterial Absorber

A graphene-loaded metamaterial absorber is investigated in the mid-infrared region. The light-graphene interaction is greatly enhanced by virtue of the coupled resonance through a cross-shaped slot. The absorption peaks show a significant blueshift with increasing Fermi level, enabling a wide range of tunability for the absorber. A simple circuit model well explains and predicts...

Repair of osteonecrosis of the femoral head

BackgroundOsteonecrosis of the femoral head (ONFH) is a common joint disease and a major cause of morbidity.ObjectiveIn this study Cervi cornus Colla (CCC) deproteinized bone scaffolds were designed and three dimensional (3D)-printed for the repair of ONFH in rats.Material and methodsThe CCC-deproteinized bone scaffolds were 3D-printed using polycaprolactone mixed with the CCC...

Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study

Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identify novel markers for CRC. We performed exome analysis of sporadic colorectal cancer (sCRC) coding regions to screen loss of function (LoF) mutation genes...

ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib

Lei-lei Niu in:Nature Research journals • PubMed • Google Scholar Search for Chuan-le Cheng in:Nature Research journals • PubMed • Google Scholar Search for Ming-Yue Li in:Nature Research journals

Corrigendum: One Step Quantum Key Distribution Based on EPR Entanglement

Entanglement Jian Li Na Li Lei-Lei Li Tao Wang RepoRts

Integrated analysis of transcriptome and proteome changes related to the Ogura cytoplasmic male sterility in cabbage

, California) for editing our manuscript. Author Contributions Conceptualization: Jungen Kang. Data curation: Miaomiao Xing, Chao Sun, Shilin Hu. Investigation: Shilin Hu, Lei Lei. Project administration

Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy

Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy Fen Wang,1,* Jia-Dong Pang,2,* Lei-lei Huang,1 Ran Wang,1 Dan Li,3 Kang Sun,4 Lian-tang Wang,1,* Li ... . 8 3 . 4 5 y b / m o c . s s e r p e v PowerdbyTCPDF( O r I g I N a l r e s e a r c h lei-lei huang 1 ran Wang 1 Dan li 3 Kang sun 4 *These authors contributed equally to this work

Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents

He Shuai Dong Xin Guo Yu-Gong Wang Bei-Lei Lei Jun-Mian Tian Jin-Ming Gao OPEN Published: xx xx xxxx Sesquiterpene lactones (STLs) are a class of plant secondary metabolites widely found in nature

Structural Failure Trends of the Assembly Welding Fixture for the Front Sidewall on the basis of Finite Element Analysis

The operating conditions of the assembly welding fixture for the front sidewall have been analyzed in this paper, and all the typical conditions have been applied with the nonlinear finite element analysis of the contact, aiming to ensure the safe utilization of the assembly welding fixture for the front sidewall of tooling equipment for the production of rail vehicles. The...

Attenuated expression of MTR in both prenatally androgenized mice and women with the hyperandrogenic phenotype of PCOS

( for its linguistic assistance during the preparation of this manuscript. Author Contributions Conceptualization: Haixiang Sun. Data curation: Lei Lei, Lijun Ding. Formal analysis: Lei Lei ... , Jianjun Zhou. Funding acquisition: Haixiang Sun. Investigation: Lei Lei. Methodology: Lei Lei, Lijun Ding, Jing Su. Project administration: Haixiang Sun, Guijun Yan. Resources: Qingqing Shi, Jianjun

Pre-detection Technology of Clothing Image Segmentation Based on GrabCut Algorithm

reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Lei Lei Deng born in

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

Huntington’s disease (HD) is caused by aberrant expansion of polyglutamine (polyQ) in the N-terminus of huntingtin (Htt). Our previous study has demonstrated that HSP90 is involved in the triage decision of Htt, but how HSP90 recognizes and regulates Htt remains elusive. We investigated the interaction between HSP90 and the N-terminal fragments of Htt (Htt-N), such as the N...

Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2

?token=clefscoqbpgxdid&;acc= GSE89587 (RAR) Author Contributions Data curation: Ying Zhang, Wei-Bin Ding, Lei-Lei Zhang, Hui-Chao Wang. Formal analysis: Ying Zhang. Funding acquisition: You-Wen Liu ... . Supervision: Ying Zhang. Writing ± original draft: Ying Zhang, Lei-Lei Zhang, Hui-Chao Wang, Ying-Jie Zhu, Yu-Na Chai, You-Wen Liu. Writing ± review & editing: Ying Zhang, Wei-Bin Ding, Lei-Lei Zhang, Hui

The N-terminal dimerization is required for TDP-43 splicing activity

TDP-43 is a nuclear factor that functions in promoting pre-mRNA splicing. Deletion of the N-terminal domain (NTD) and nuclear localization signal (NLS) (i.e., TDP-35) results in mislocalization to cytoplasm and formation of inclusions. However, how the NTD functions in TDP-43 activity and proteinopathy remains largely unknown. Here, we studied the structure and function of the...

Association Between Helicobacter Pylori Infection and Long-term Outcome in Patients with Drug-eluting Stent Implantation

To investigate the relationship between Helicobacter pylori (Hp) infection and the long-term outcome in acute coronary syndrome (ACS) patients with drug-eluting stent (DES) implantation and so as to explore the significance of Hp eradication therapy in preventing major adverse cardiac events (MACE) and upper gastrointestinal bleeding (UGIB). 539 ACS patients with DES implantation...