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Search: authors:"Lei Lei"

101 papers found.
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40-Gb/s all-optical digital 4-bit priority encoder employing cross-gain modulation in semiconductor optical amplifiers

High-speed all-optical logic circuits have attracted much attention because of their important roles in signal processing in next-generation optical networks. The digital encoder is widely used in binary calculation, multiplexing, demultiplexing, address recognition and data encryption. A priority encoder allows the existence of multiple valid inputs simultaneously, identifies...

A New Similarity Measure between Intuitionistic Fuzzy Sets and Its Application to Pattern Recognition

As a generation of ordinary fuzzy set, the concept of intuitionistic fuzzy set (IFS), characterized both by a membership degree and by a nonmembership degree, is a more flexible way to cope with the uncertainty. Similarity measures of intuitionistic fuzzy sets are used to indicate the similarity degree between intuitionistic fuzzy sets. Although many similarity measures for...

A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson’s Disease

tware.? T he sequence was password-protected and kept in a computer by Lei-Lei Chen. Group allocation was stratified block randomization according to their H&Y stages at the screening. The sequential ... ; Ka-Kit Chua and Yin-Kei Lau helped carry out and monitor the clinical trial; Lei-Lei Chen generated the randomization sequence; Kim-Pong Tse distributed the medicine; Li- Xing Zhu, Kam-Wa Chan, Ka-Ho

A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson’s Disease

Liu,1,2 Lei-Lei Chen,1,2 Ka-Ho Chan,1 Kim-Pong Tse,1 Anne Chan,3 Ju-Xian Song,1,2 Justin Wu,3 Li-Xing Zhu,5 Vincent Mok,3 and Min Li1,2 1School of Chinese Medicine, Hong Kong Baptist University ... 6-week observation period without treatment. The randomization sequence was generated by “Random Allocation Software.” The sequence was password-protected and kept in a computer by Lei-Lei Chen. Group

A Segmentation Method for Lung Parenchyma Image Sequences Based on Superpixels and a Self-Generating Neural Forest

Background Lung parenchyma segmentation is often performed as an important pre-processing step in the computer-aided diagnosis of lung nodules based on CT image sequences. However, existing lung parenchyma image segmentation methods cannot fully segment all lung parenchyma images and have a slow processing speed, particularly for images in the top and bottom of the lung and the...

A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients

A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients Zeng Wang,1,2 Lei Lei,2,3 Xin-jun

Acetobixan, an Inhibitor of Cellulose Synthesis Identified by Microbial Bioprospecting

In plants, cellulose biosynthesis is an essential process for anisotropic growth and therefore is an ideal target for inhibition. Based on the documented utility of small-molecule inhibitors to dissect complex cellular processes we identified a cellulose biosynthesis inhibitor (CBI), named acetobixan, by bio-prospecting among compounds secreted by endophytic microorganisms...

Acoustic one-way metasurfaces: Asymmetric Phase Modulation of Sound by Subwavelength Layer

• PubMed • Google ScholarSearch for Xin-ye Zou in:Nature Research journals • PubMed • Google ScholarSearch for Jing Yang in:Nature Research journals • PubMed • Google ScholarSearch for Lei-lei Yin in:Nature

Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study

Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identify novel markers for CRC. We performed exome analysis of sporadic colorectal cancer (sCRC) coding regions to screen loss of function (LoF) mutation genes...

Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner

Background C. trachomatis organisms carry a cryptic plasmid that encodes 8 open reading frames designated as pORF1 to 8. It is not clear whether all 8 pORFs are expressed during C. trachomatis infection in humans and information on the functionality of the plasmid proteins is also very limited. Results When antibodies from women urogenitally infected with C. trachomatis were...

Association Between Helicobacter Pylori Infection and Long-term Outcome in Patients with Drug-eluting Stent Implantation

To investigate the relationship between Helicobacter pylori (Hp) infection and the long-term outcome in acute coronary syndrome (ACS) patients with drug-eluting stent (DES) implantation and so as to explore the significance of Hp eradication therapy in preventing major adverse cardiac events (MACE) and upper gastrointestinal bleeding (UGIB). 539 ACS patients with DES implantation...

Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population

Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Currently, numerous genetic loci of SLE have been confirmed. Here we try to further explore additional genes contributing to SLE susceptibility in this study. Methods Forty nine single nucleotide polymorphisms (SNPs) with moderate-risk for SLE in previous study were genotyped in a large-scale...

Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress

Background 3-Hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive inhibitors of the rate-limiting enzyme in cholesterol biosynthesis. Currently, statins are used as first-line therapy in the treatment of diabetic dyslipidemia. However, effects of statins on β cell function remains unclear. This study aims to examine effects of atorvastatin...

Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress

3-Hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive inhibitors of the rate-limiting enzyme in cholesterol biosynthesis. Currently, statins are used as first-line therapy in the treatment of diabetic dyslipidemia. However, effects of statins on β cell function remains unclear. This study aims to examine effects of atorvastatin treatment on...

Attenuated expression of MTR in both prenatally androgenized mice and women with the hyperandrogenic phenotype of PCOS

(www.letpub.com) for its linguistic assistance during the preparation of this manuscript. Author Contributions Conceptualization: Haixiang Sun. Data curation: Lei Lei, Lijun Ding. Formal analysis: Lei Lei ... , Jianjun Zhou. Funding acquisition: Haixiang Sun. Investigation: Lei Lei. Methodology: Lei Lei, Lijun Ding, Jing Su. Project administration: Haixiang Sun, Guijun Yan. Resources: Qingqing Shi, Jianjun

Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage

Azinomycin B is a hybrid polyketide/nonribosomal peptide natural product and possesses antitumor activity by interacting covalently with duplex DNA and inducing interstrand crosslinks. In the biosynthetic study of azinomycin B, a gene (orf1) adjacent to the azinomycin B gene cluster was found to be essential for the survival of the producer, Streptomyces sahachiroi ATCC33158...

Characterization of the Specific CD4+ T Cell Response against the F Protein during Chronic Hepatitis C Virus Infection

Background The hepatitis C virus (HCV) Alternate Reading Frame Protein (ARFP or F protein) presents a double-frame shift product of the HCV core gene. We and others have previously reported that the specific antibodies against the F protein could be raised in the sera of HCV chronically infected patients. However, the specific CD4+ T cell responses against the F protein during...

Chemical Differentiation of Dendrobium officinale and Dendrobium devonianum by Using HPLC Fingerprints, HPLC-ESI-MS, and HPTLC Analyses

The stems of Dendrobium officinale Kimura et Migo (Dendrobii Officinalis Caulis) have a high medicinal value as a traditional Chinese medicine (TCM). Because of the limited supply, D. officinale is a high priced TCM, and therefore adulterants are commonly found in the herbal market. The dried stems of a closely related Dendrobium species, Dendrobium devonianum Paxt., are commonly...

Chlamydia trachomatis GlgA Is Secreted into Host Cell Cytoplasm

Glycogen has been localized both inside and outside Chlamydia trachomatis organisms. We now report that C. trachomatis glycogen synthase (GlgA) was detected in both chlamydial organism-associated and -free forms. The organism-free GlgA molecules were localized both in the lumen of chlamydial inclusions and in the cytosol of host cells. The cytosolic GlgA displayed a distribution...