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The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression

In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanisms of circRNAs in triple-negative breast cancer (TNBC) still remain...

Current Rectification in a Structure: ReSe2/Au Contacts on Both Sides of ReSe2

Transition metal dichalcogenides Tingting Miao, Dongwei Yu and Lei Xing contributed equally to this work. Introduction Rectification behaviors of metal-semiconductor contacts, where the current varies

Tensor framelet based iterative image reconstruction algorithm for low-dose multislice helical CT

related to Fig 11. (MAT) 14 / 17 Author Contributions Conceptualization: Haewon Nam, Lei Xing, Hao Gao. Data curation: Haewon Nam, Keumsil Lee, Ruijiang Li, Bin Han. Formal analysis: Haewon Nam. Funding ... acquisition: Rena Lee. Methodology: Haewon Nam, Hao Gao. Resources: Minghao Guo, Bin Han. Software: Haewon Nam, Minghao Guo, Hengyong Yu, Keumsil Lee, Ruijiang Li. Supervision: Hengyong Yu, Lei Xing, Hao Gao

Improved crop yield and reduced nitrate nitrogen leaching with straw return in a rice-wheat rotation of Ningxia irrigation district

the main manuscript, Yongsheng Wang, Ruliang Liu and Lei Xing conducted the field experiments and prepared the tables and figures, and Zhengli Yang contributed ideas. Additional Information Competing

Genomic and transcriptomic comparison of Aspergillus oryzae strains: a case study in soy sauce koji fermentation

The filamentous fungus Aspergillus oryzae is used in soy sauce koji making due to its high productivity of hydrolytic enzymes. In this study, we compared the genomes and transcriptomes of an industrial strain RD2 and a strain with decreased fermentation performance TS2, aiming to explain their phenotypic differences at the molecular level. Under the regulation of conidiation and...

Imaging cellular pharmacokinetics of 18F-FDG and 6-NBDG uptake by inflammatory and stem cells

, Phillip C. Yang, Frederick T. Chin. Writing ± original draft: Raiyan T. Zaman, Morteza Mahmoudi. Writing ± review & editing: Silvan Tuerkcan, Phillip C. Yang, Michael V. McConnell, Lei Xing. 11 / 13 12

Building Up a Robust Risk Mathematical Platform to Predict Colorectal Cancer

Colorectal cancer (CRC), as a result of a multistep process and under multiple factors, is one of the most common life-threatening cancers worldwide. To identify the “high risk” populations is critical for early diagnosis and improvement of overall survival rate. Of the complicated genetic and environmental factors, which group is mostly concerning colorectal carcinogenesis...

A Dual-Modality Hybrid Imaging System Harnesses Radioluminescence and Sound to Reveal Molecular Pathology of Atherosclerotic Plaques

Search for K. Kirk Shung in:Nature Research journals • PubMed • Google Scholar Search for Lei Xing in:Nature Research journals • PubMed • Google Scholar Contributions Specific contribution of the

Recombinant production of medium- to large-sized peptides in Escherichia coli using a cleavable self-aggregating tag

Background Peptides have recently become attractive for therapeutic applications. However, efficient production of medium- to large-sized peptides (30–100 amino acids [aa]) remains challenging both by recombinant and chemical synthesis. We previously reported the formation of active enzyme aggregates in Escherichia coli cells induced by the short β-structured peptide ELK16...

High Resolution X-ray-Induced Acoustic Tomography

Absorption based CT imaging has been an invaluable tool in medical diagnosis, biology, and materials science. However, CT requires a large set of projection data and high radiation dose to achieve superior image quality. In this letter, we report a new imaging modality, X-ray Induced Acoustic Tomography (XACT), which takes advantages of high sensitivity to X-ray absorption and...

Two Alternative Methods to Measure the Radiated Emission in a Reverberation Chamber

One of the most important applications of a reverberation chamber is for radiated power measurement. Two new alternative methods are proposed to measure the radiated power of equipment under test in a reverberation chamber in this paper. Traditionally, as stated in IEC 61000-4-21 standard, this measurement requires two antennas, a signal generator and a spectrum analyzer or...

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy Cheng-Qiong Luo,1–3,* Lei Xing,1–3,* Peng-Fei Cui,1 Jian-Bin

Dosimetric analysis of isocentrically shielded volumetric modulated arc therapy for locally recurrent nasopharyngeal cancer

This study aimed to investigate the dosimetric characteristics of an isocentrically shielded RapidArc (IS-RA) technique for treatment of locally recurrent nasopharyngeal cancer (lrNPC). In IS-RA, the isocenter was placed at the center of the pre-irradiated brainstem (BS)/spinal cord (SC) and the jaws were set to shield the BS/SC while ensuring the target coverage during the whole...

Dual-gated volumetric modulated arc therapy

Background Gated Volumetric Modulated Arc Therapy (VMAT) is an emerging radiation therapy modality for treatment of tumors affected by respiratory motion. However, gating significantly prolongs the treatment time, as delivery is only activated during a single respiratory phase. To enhance the efficiency of gated VMAT delivery, a novel dual-gated VMAT (DG-VMAT) technique, in which...

Early Change in Metabolic Tumor Heterogeneity during Chemoradiotherapy and Its Prognostic Value for Patients with Locally Advanced Non-Small Cell Lung Cancer

/analysis tools: YH WL HW JY. Wrote the paper: XD PGM Lei Xing. Designed the software used in analysis: XD HW. 12 / 14 13 / 14 cancer, and addition of bevacizumab to neoadjuvant trastuzumab and docetaxel in

Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis. Here, we have determined the functions of ERK/MAPK signaling in developing neocortical excitatory neurons. Our data reveal a critical requirement for ERK/MAPK signaling in the morphological...

Fiber-Optic System for Dual-Modality Imaging of Glucose Probes 18F-FDG and 6-NBDG in Atherosclerotic Plaques

Background Atherosclerosis is a progressive inflammatory condition that underlies coronary artery disease (CAD)–the leading cause of death in the United States. Thus, the ultimate goal of this research is to advance our understanding of human CAD by improving the characterization of metabolically active vulnerable plaques within the coronary arteries using a novel catheter-based...

Transient Response and Steady-State Analysis of the Anode of Direct Methanol Fuel Cells Based on Dual-Site Kinetics

; Accepted 4 May 2011 Academic Editor: Shuangyin Wang Copyright © 2011 Lei Xing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted

Facile Synthesis of Amine-Functionalized Eu3+-Doped La(OH)3 Nanophosphors for Bioimaging

Here, we report a straightforward synthesis process to produce colloidal Eu3+-activated nanophosphors (NPs) for use as bioimaging probes. In this procedure, poly(ethylene glycol) serves as a high-boiling point solvent allowing for nanoscale particle formation as well as a convenient medium for solvent exchange and subsequent surface modification. The La(OH)3:Eu3+ NPs produced by...

Streamlined protein expression and purification using cleavable self-aggregating tags

Background Recombinant protein expression and purification remains a fundamental issue for biotechnology. Recently we found that two short self-assembling amphipathic peptides 18A (EWLKAFYEKVLEKLKELF) and ELK16 (LELELKLKLELELKLK) can induce the formation of active protein aggregates in Escherichia coli (E. coli), in which the target proteins retain high enzymatic activities. Here...