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Investigation and genome-wide association study for Fusarium crown rot resistance in Chinese common wheat

Fusarium crown rot (FCR) is a severe and chronic disease in common wheat and is able to cause serious yield loss and health problems to human and livestock. Here, 234 Chinese wheat cultivars were evaluated in four greenhouse experiments for FCR resistance and genome-wide association studies (GWAS) were performed using the wheat 660 K genotyping assay. The results indicated that...

Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway

glioma cell line U251 was purchased from the China Center for Type Culture Collection (CCTCC). The human embryo liver cell line LO2 was characterized by Professor Lei Zhao (Union Hospital, Tongji Medical

Temperature-Dependent Electrical Transport Properties of Individual NiCo2O4 Nanowire

Understanding the electrical transport properties of individual nanostructures is of great importance to the construction of high-performance nanodevices. NiCo2O4 nanowires have been investigated widely as the electrodes in electrocatalysis, supercapacitors, and lithium batteries. However, the exact electrical transport mechanism of an individual NiCo2O4 nanowire is still...

High content screening identifies monensin as an EMT-selective cytotoxic compound

Epithelial-to-mesenchymal transition (EMT) is implicated in cancer metastasis and drug resistance. Specifically targeting cancer cells in an EMT-like state may have therapeutic value. In this study, we developed a cell imaging-based high-content screening protocol to identify EMT-selective cytotoxic compounds. Among the 2,640 compounds tested, salinomycin and monensin, both...

Modified Wendan Decoction Can Attenuate Neurotoxic Action Associated with Alzheimer's Disease

We observed the effect of modified Wendan decoction (modified Wen-Dan-Tang) on a cellular model of Alzheimer's disease. Amyloid beta (AΒ) 25–35 segment neurotoxin was employed to induce a PC12 cellular model of Alzheimer's disease. After modified Wendan decoction was fed to rats, the serum containing medicine was prepared and changes in cell morphology observed. Cell mortality...

Modified Wendan Decoction Can Attenuate Neurotoxic Action Associated with Alzheimer's Disease

We observed the effect of modified Wendan decoction (modified Wen-Dan-Tang) on a cellular model of Alzheimer's disease. Amyloid beta (AΒ) 25–35 segment neurotoxin was employed to induce a PC12 cellular model of Alzheimer's disease. After modified Wendan decoction was fed to rats, the serum containing medicine was prepared and changes in cell morphology observed. Cell mortality...

The effect of fenofibrate on early retinal nerve fiber layer loss in type 2 diabetic patients: a case-control study

Previous studies suggested that use of fenofibrate could significantly reduce the rate of progression into diabetic retinopathy (DR), and that retinal nerve fiber layer (RNFL) loss, which has been considered an important indicator for retinal neurodegeneration, might precede microvascular changes. The aim of this study was to assess the effect(s) of fenofibrate on RNFL thickness...

Smart Shift Decision Method Based on Stacked Autoencoders

Manual calibration and testing on real vehicles are common methods of generating shifting schedules for newly developed vehicles. However, these methods are time-consuming. Shifting gear timing is an important operating parameter that affects shifting time, power loss, fuel efficiency, and driver comfort. The stacked autoencoder (SAE) algorithm, a type of artificial neural...

Smart Shift Decision Method Based on Stacked Autoencoders

Manual calibration and testing on real vehicles are common methods of generating shifting schedules for newly developed vehicles. However, these methods are time-consuming. Shifting gear timing is an important operating parameter that affects shifting time, power loss, fuel efficiency, and driver comfort. The stacked autoencoder (SAE) algorithm, a type of artificial neural...

Smart Shift Decision Method Based on Stacked Autoencoders

Manual calibration and testing on real vehicles are common methods of generating shifting schedules for newly developed vehicles. However, these methods are time-consuming. Shifting gear timing is an important operating parameter that affects shifting time, power loss, fuel efficiency, and driver comfort. The stacked autoencoder (SAE) algorithm, a type of artificial neural...

Design of Lattice Structures Using Local Relative Density Mapping Method

management, design theory and method, and manufacturing services technology. Fang-Lei Zhao, born in 1991, is currently a master candidate at School of Mechanical Engineering, Beijing Institute of Technology

Correction to: IL-39 acts as a friend to pancreatic cancer

 G. RedingtonVivi A. DingTheodore Stewart-HesterQian BaiJacob DunlapMark R. WakefieldYujiang Fang Correction First Online: 22 January 2019 109 Downloads Alicia A. Manning and Lei Zhao

N-Butanol Extract from Melilotus suaveolens Ledeb Affects Pro- and Anti-Inflammatory Cytokines and Mediators

Melilotus suaveolens Ledeb is a traditional medicinal plant for treating inflammation-related disease. This explores the inner anti-inflammatory mechanism of n-butanol extract from M. suaveolens Ledeb. Inflammatory cellular model was established by lipopolysaccharide intervention on RAW264.7 cell line. Levels of secreted cytokines TNF-α, IL-1β, IL-6, NO and IL-10 in supernatant...

Icariin Improves the Viability and Function of Cryopreserved Human Nucleus Pulposus-Derived Mesenchymal Stem Cells

Ma conceived and designed the experiments. Sheng Chen and Xiangyu Deng performed the experiments. Lei Zhao and Donghua Huang analyzed the data, prepared the figures, and wrote the original manuscript

Icariin Improves the Viability and Function of Cryopreserved Human Nucleus Pulposus-Derived Mesenchymal Stem Cells

Ma conceived and designed the experiments. Sheng Chen and Xiangyu Deng performed the experiments. Lei Zhao and Donghua Huang analyzed the data, prepared the figures, and wrote the original manuscript

Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder

Ye Yuan,2 Jixiang Wang,4 Yongchao Zhang,4 Lei Zhao,4 Meng Zhang,4 Yu Kang,2 Ying Liang1 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental

Analyzing the Molecular Kinetics of Water Spreading on Hydrophobic Surfaces via Molecular Dynamics Simulation

In this paper, we report molecular kinetic analyses of water spreading on hydrophobic surfaces via molecular dynamics simulation. The hydrophobic surfaces are composed of amorphous polytetrafluoroethylene (PTFE) with a static contact angle of ~112.4° for water. On the basis of the molecular kinetic theory (MKT), the influences of both viscous damping and solid-liquid retarding...

Experimental Study on the Shear Strength of Cement-Sand-Gravel Material

An experimental study on the shear strength development of cement-sand-gravel (CSG) material was carried out using triaxial compression tests. The effects of the cementing agent content, aggregate content, and gradation on the shear strength of CSG material were analyzed. The shear strength remarkably increased with increasing cementing agent content and aggregate content for a...

Experimental Study on the Shear Strength of Cement-Sand-Gravel Material

An experimental study on the shear strength development of cement-sand-gravel (CSG) material was carried out using triaxial compression tests. The effects of the cementing agent content, aggregate content, and gradation on the shear strength of CSG material were analyzed. The shear strength remarkably increased with increasing cementing agent content and aggregate content for a...

An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos

Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility and transcriptome landscapes for human pre-implantation embryos...