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Search: authors:"Lena K. Afeyan"

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High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

The development of site-specific recombinases (SSRs) as genome editing agents is limited by the difficulty of altering their native DNA specificities. Here we describe Rec-seq, a method for revealing the DNA specificity determinants and potential off-target substrates of SSRs in a comprehensive and unbiased manner. We applied Rec-seq to characterize the DNA specificity...