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Search: authors:"Leon Bichmann"

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Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

BackgroundAlthough mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). Employing a unique multi-omics approach comprising a neoepitope identification pipeline, we assessed exome-derived mutations naturally presented as HLA class I ligands in HCCs.MethodsIn-depth multi-omics...