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Structural and molecular basis of angiotensin-converting enzyme by computational modeling: Insights into the mechanisms of different inhibitors

: Weihong Min. Writing ? original draft: Li Fang. Writing ? review & editing: Li Fang. 14 / 16 15 / 16 1. Natesh R , Schwager SLU , Sturrock ED , Acharya R . Crystal structure of the human angiotensin

Targeting GPER1 to suppress autophagy as a male-specific therapeutic strategy for iron-induced striatal injury

The functional outcome of intracerebral hemorrhage (ICH) in young male patients are poor than in premenopausal women. After ICH, ferrous iron accumulation causes a higher level of oxidative injury associated with autophagic cell death in striatum of male mice than in females. In rodent model of ferrous citrate (FC)-infusion that simulates iron accumulation after ICH, female...

Linear maps preserving the idempotency of Jordan products of operators

′ with f2(x2) = 21λ , we get Ax2 ⊗f2 +x2 ⊗f2A ∈ I∗(X ), which implies ϕ(A)ϕ(x2 ⊗f2)+ϕ(x2 ⊗f2)ϕ(A) ∈ I∗(X ). 770 Li Fang But ϕ(A)ϕ(x2 ⊗f2)+ϕ(x2 ⊗f2)ϕ(A) = 0 and we get a contradiction. When μ−λ2 = 0 and λ ... = 0, we also get 772 Li Fang a contradiction using a similar argument above. For the case that A2 6= 0, there is an x6 ∈ X such that Ax6 and A2x6 are linearly independent. Selecting f6 ∈ X ′ such that

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes in an older adult mimicking cerebral infarction: a Chinese case report

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes in an older adult mimicking cerebral infarction: a Chinese case report Gao-Li Fang,1 Yang Zheng,2 Yin-Xi Zhang2 ... Gao-Li Fang,1 Yang Zheng,2 Yin-Xi Zhang2 1Department of Neurology, Hangzhou Red Cross Hospital, Hangzhou, China; 2Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang

Atherogenic index of plasma is a novel predictor of non-alcoholic fatty liver disease in obese participants: a cross-sectional study

The atherogenic index of plasma showed to be related with some chronic disease like cardiovascular diseases and atherosclerosis. Body mass index which was commonly used in clinical practice is not an accurate index to predict non-alcoholic fatty liver disease. The aim of this study is to investigate the relationship between atherogenic index of plasma and non-alcoholic fatty...

The association between IGF1 gene rs1520220 polymorphism and cancer susceptibility: a meta-analysis based on 12,884 cases and 58,304 controls

, Wei-Xian Chen2, Wen-Yue Xie3 and Li-Fang Wu2Email authorView ORCID ID profile Environmental Health and Preventive Medicine201823:38 https://doi.org/10.1186/s12199-018-0727-y ©  The Author(s). 2018

Impact of Using Near Real-Time Green Vegetation Fraction in Noah Land Surface Model of NOAA NCEP on Numerical Weather Predictions

, USA 3NASA Marshall Space Flight Center, Redstone Arsenal, Huntsville, AL 35812, USA Correspondence should be addressed to Li Fang; Received 3 January 2018; Revised 23 March 2018; Accepted 11 April ... 2018; Published 5 June 2018 Academic Editor: Qingyan Meng Copyright © 2018 Li Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Protein Hydrolyzates from Changbai Mountain Walnut (Juglans mandshurica Maxim.) Boost Mouse Immune System and Exhibit Immunoregulatory Activities

The Changbai Mountain walnut (Juglans mandshurica Maxim.) is a rich source of essential amino acids. Walnut dregs are byproducts of edible oil production and primarily used as fodder and fertilizers. We systematically examined the effect of three types of walnut protein hydrolyzates—albumin, glutelin, and globin—on the immune system of mice and aimed to provide the theoretical...

Protein Hydrolyzates from Changbai Mountain Walnut (Juglans mandshurica Maxim.) Boost Mouse Immune System and Exhibit Immunoregulatory Activities

The Changbai Mountain walnut (Juglans mandshurica Maxim.) is a rich source of essential amino acids. Walnut dregs are byproducts of edible oil production and primarily used as fodder and fertilizers. We systematically examined the effect of three types of walnut protein hydrolyzates—albumin, glutelin, and globin—on the immune system of mice and aimed to provide the theoretical...

Prevalence, awareness, treatment and control of diabetes mellitus among middle-aged and elderly people in a rural Chinese population: A cross-sectional study

administration: Li Fang, Qingbo Guan. Resources: Li Fang, Qingbo Guan. Software: Qian Wang. Supervision: Liying Guan. Validation: Liying Guan. Visualization: Liying Guan. Writing ? original draft: Qian Wang

Controlled study on Gamma nail and proximal femoral locking plate for unstable intertrochanteric femoral fractures with broken lateral wall

-fu Quan Wei-li Fang Bo Jin Wei-long Lin OPEN The gamma nail and proximal femoral locking plate (PFLP) are both used for fractures. A controlled study was performed to determine the optimal implant. To

Bayesian nonparametric discovery of isoforms and individual specific quantification

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A Revised Model of the Neutral DEA Model and Its Extension

The neutral data envelopment analysis (DEA) model is an alternative way to determine the weights in DEA cross-efficiency evaluation, while avoiding the difficulty in making a choice between the aggressive and benevolent formulations. However, the weights determined by the neutral model merely make the efficiency of part output bigger than other sets of weights. The neutral model...

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

Chen,2 Yun Shen,2 Fen Wang,3 Li-Fang Hu,3 and Chun-Feng Liu2,3 1Department of Neurology, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou 215008, China 2Department of Neurology and Suzhou

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease and is known to involve circadian dysfunction and oxidative stress. Although antioxidative defense is regulated by the molecular circadian clock, few studies have examined their function in PD and their regulation by silent information regulator 1 (SIRT1). We hypothesize that reduced antioxidative...

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

Chen,2 Yun Shen,2 Fen Wang,3 Li-Fang Hu,3 and Chun-Feng Liu2,3 1Department of Neurology, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou 215008, China 2Department of Neurology and Suzhou

Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair

Search for Chau-Ting Yeh in:Nature Research journals • PubMed • Google Scholar Search for Jar-Yi Ho in:Nature Research journals • PubMed • Google Scholar Search for Li-Fang Chou in:Nature Research

p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling

To protect against oxidative stress-induced apoptosis in lens epithelial cells is a potential strategy in preventing cataract formation. The present study aimed at studying the protective effect and underlying mechanisms of p-coumaric acid (p-CA) on hydrogen peroxide- (H2O2-) induced apoptosis in human lens epithelial (HLE) cells (SRA 01–04). Cells were pretreated with p-CA at a...

p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling

To protect against oxidative stress-induced apoptosis in lens epithelial cells is a potential strategy in preventing cataract formation. The present study aimed at studying the protective effect and underlying mechanisms of p-coumaric acid (p-CA) on hydrogen peroxide- (H2O2-) induced apoptosis in human lens epithelial (HLE) cells (SRA 01–04). Cells were pretreated with p-CA at a...