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Mortality of Elderly Patients in Ontario after Hospital Admission for Chronic Obstructive Pulmonary Disease

JX Nie, Li Wang, REG Upshur. Mortality of elderly patients in Ontario after hospital admission for chronic obstructive pulmonary disease. Can Respir J Mortality of elderly patients in Ontario after ... hospital admission for chronic obstructive pulmonary disease Jason X Nie Li Wang MSc Ross EG Upshur MA MSc CCFP FRCPC BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with

Benefit of early discharge among patients with low-risk pulmonary embolism

, Craig I. Coleman, Gregory J. Fermann, Jeff Schein, Concetta Crivera. Data curation: Li Wang, Onur Baser. Formal analysis: Li Wang, Onur Baser. Writing ± original draft: Li Wang, Onur Baser, Phil Wells ... , W. Frank Peacock, Craig I. Coleman, Gregory J. Fermann, Jeff Schein, Concetta Crivera. Writing ± review & editing: Li Wang, Onur Baser, Phil Wells, W. Frank Peacock, Craig I. Coleman, Gregory J

Health-related quality of life in children with chronic immune thrombocytopenia in China

Background The concept of health-related quality of life (HRQoL) was brought up decades ago and has been well utilized in many different areas. Regarding immune thrombocytopenia (ITP) management, much work has been done to emphasize the necessity of taking HRQoL into consideration. However, data on HRQoL of children with chronic ITP remain rare. Methods This is a cross-sectional...

Health-related quality of life in children with chronic immune thrombocytopenia in China

The concept of health-related quality of life (HRQoL) was brought up decades ago and has been well utilized in many different areas. Regarding immune thrombocytopenia (ITP) management, much work has been done to emphasize the necessity of taking HRQoL into consideration. However, data on HRQoL of children with chronic ITP remain rare. This is a cross-sectional study. Children...

Brazilian oral herbal medication for osteoarthritis: a systematic review protocol

Background Osteoarthritis affects 1 % of the world’s population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with osteoarthritis, and some of them are financed by the Brazilian government; however, the effectiveness of most of these agents is uncertain. The aim was to...

Modeling the Pulse Signal by Wave-Shape Function and Analyzing by Synchrosqueezing Transform

We apply the recently developed adaptive non-harmonic model based on the wave-shape function, as well as the time-frequency analysis tool called synchrosqueezing transform (SST) to model and analyze oscillatory physiological signals. To demonstrate how the model and algorithm work, we apply them to study the pulse wave signal. By extracting features called the spectral pulse...

Probiotic and anti-inflammatory attributes of an isolate Lactobacillus helveticus NS8 from Mongolian fermented koumiss

Background Koumiss is a traditionally fermented mare’s milk described with health-promoting potentials for decades. However, only a few studies focused on the probiotic strains isolated from koumiss. In this study, we collected koumiss samples from Inner Mongolian pasturing area of China and selected a promising strain of Lactobacillus helveticus, isolate NS8, based on the...

Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: a systematic review and meta-analysis of randomized trials

of ketamine to morphine/ Author contributions Li Wang contributed to study conception, drafting the manuscript, and manuscript revisions based on the comments of the coauthors. Li Wang, Bradley ... Johnston, and Janet Martin contributed to the study design. Li Wang, Alka Kaushal, and Fang Zhu were involved in the acquisition of data. Li Wang contributed to the data analysis. Li Wang, Davy Cheng, and

Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice

Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the brain and blood of Parkinson’s disease (PD) patients. The present study investigated the hypothesis that augmenting plasmalogens could protect striatal dopamine neurons that degenerate in response to 1-methyl-4-phenyl-1,2,3,6...

Performance of Genotype Imputation for Low Frequency and Rare Variants from the 1000 Genomes

Genotype imputation is now routinely applied in genome-wide association studies (GWAS) and meta-analyses. However, most of the imputations have been run using HapMap samples as reference, imputation of low frequency and rare variants (minor allele frequency (MAF) < 5%) are not systemically assessed. With the emergence of next-generation sequencing, large reference panels (such as...

Medical characteristics of the oldest old: retrospective chart review of patients aged 85+ in an academic primary care centre

5 Hiu-Wah Li 5 Jason X Nie 4 C Shawn Tracy 4 Li Wang 3 Ross EG Upshur 2 4 0 Mount Sinai Hospital Sherman Health and Wellness Centre , 9600 Bathurst Street, Suite 300, Vaughan L6A3Z8, ON , Canada 1

Preferential regulation of stably expressed genes in the human genome suggests a widespread expression buffering role of microRNAs

Zhen Yang 0 Dong Dong Zhaolei Zhang M James C Crabbe Li Wang Yang Zhong 0 0 School of Life Sciences, Fudan University , Shanghai, 200433 , China Background: MicroRNAs (miRNAs) are a class of small

Effect of GA3 Treatment on Seed Development and Seed-Related Gene Expression in Grape

BackgroundThe phytohormone gibberellic acid (GA3) is widely used in the table grape industry to induce seedlessness in seeded varieties. However, there is a paucity of information concerning the mechanisms by which GAs induce seedlessness in grapes. Methodology/Principal FindingsIn an effort to systematically analyze the cause of this GA3-induced seed abortion, we conducted an in...

Mental Health Problems among Children One-Year after Sichuan Earthquake in China: A Follow-up Study

Background On May 12, 2008, a destructive earthquake registering 8.0 on the Richter scale struck Sichuan Province, southwest China. Beichuan County was the epicenter which was one of the areas nearly completely destroyed by the earthquake. In Beichuan, about 15000 people died and 3000 people were missing. Specially, the earthquake took 1587 students' and 214 teachers' lives from...

Parent-reported health care expenditures associated with autism spectrum disorders in Heilongjiang province, China

Background The aim of this study was to determine the health expenses incurred by families with children with autism spectrum disorder (ASD) and those expenses' relation to total household income and expenditures. Methods In this cross-sectional study, health care expenditure data were collected through face-to-face interviews. Expenses included annual costs for clinic visits...

Measuring change in health status of older adults at the population level: The transition probability model

Background The current demographic transition will lead to increasing demands on health services. However, debate exists as to the role age plays relative to co-morbidity in terms of health services utilization. While age has been identified as a critical factor in health services utilization, health services utilization is not simply an outcome of ill health, nor is it an...

From pharmaco-therapy to pharmaco-prevention: trends in prescribing to older adults in Ontario, Canada, 1997-2006

Background The developed world is undergoing a demographic transition with greater numbers of older adults and higher rates of chronic disease. Most elder care is now provided by primary care physicians, who prescribe the majority of medications taken by these patients. Despite these significant trends, little is known about population-level prescribing patterns to primary care...

The influence of cathelicidin LL37 in human anti-neutrophils cytoplasmic antibody (ANCA)-associated vasculitis

Introduction Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterised by the autoinflammation and necrosis of blood vessel walls. The renal involvement is commonly characterised by a pauci-immune crescentic glomerulonephritis (PiCGN) with a very rapid decline in renal function. Cathelicidin LL37, an endogenous antimicrobial peptide, has recently...

The DNA Methylome and Transcriptome of Different Brain Regions in Schizophrenia and Bipolar Disorder

Extensive changes in DNA methylation have been observed in schizophrenia (SC) and bipolar disorder (BP), and may contribute to the pathogenesis of these disorders. Here, we performed genome-scale DNA methylation profiling using methylated DNA immunoprecipitation followed by sequencing (MeDIP-seq) on two brain regions (including frontal cortex and anterior cingulate) in 5 SC, 7 BP...

Trends in health services utilization, medication use, and health conditions among older adults: a 2-year retrospective chart review in a primary care practice

Background Population aging poses significant challenges to primary care providers and healthcare policy makers. Primary care reform can alleviate the pressures, but these initiatives require clinical benchmarks and evidence regarding utilization patterns. The objectives of this study is to measure older patients' use of health services, number of health conditions, and use of...