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Global time trends in the incidence of esophageal squamous cell carcinoma

Global time trends in the incidence of esophageal squamous cell carcinoma Qiao-Li Wang,1 Shao-Hua Xie,1 Karl Wahlin,1 Jesper Lagergren1,2 1Upper Gastrointestinal Surgery, Department of Molecular

Identification of a Splicing Mutation in ITPR1 via WES in a Chinese Early-Onset Spinocerebellar Ataxia Family

ataxia type 15/29 (SCA15/29); Whole-exome sequencing (WES) - Li Wang and Ying Hao contributed equally to this work. Introduction The spinocerebellar ataxias (SCAs) are known as a group of genetically

Biosynthesis of silver nanoparticles by the fungus Arthroderma fulvum and its antifungal activity against genera of Candida, Aspergillus and Fusarium

Biosynthesis of silver nanoparticles by the fungus Arthroderma fulvum and its antifungal activity against genera of Candida, Aspergillus and Fusarium Baiji Xue,1 Dan He,1 Song Gao,1 Dongyang Wang,1 Koji Yokoyama,2 Li Wang1 1Department of Pathogenobiology, Jilin University Mycology Research Center, Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical...

Design and tailoring of patterned ZnO nanostructures for energy conversion applications

ZnO is a typical direct wide-bandgap semiconductor material, which has various morphologies and unique physical and chemical properties, and is widely used in the fields of energy, information technology, biomedicine, and others. The precise design and controllable fabrication of nanostructures have gradually become important avenues to further enhancing the performance of ZnO...

Evolutionary History of Atmospheric CO2 during the Late Cenozoic from Fossilized Metasequoia Needles

The change in ancient atmospheric CO2 concentrations provides important clues for understanding the relationship between the atmospheric CO2 concentration and global temperature. However, the lack of CO2 evolution curves estimated from a single terrestrial proxy prevents the understanding of climatic and environmental impacts due to variations in data. Thus, based on the stomatal...

Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts

Imamura 0 Pao-Li Wang 1 0 Department of Pharmacology, Matsumoto Dental University , Shiojiri, Nagano , Japan 1 Department of Dental Education Innovation, Osaka Dental University , Hirakata, Osaka , Japan

Expression of Cell Competition Markers at the Interface between p53 Signature and Normal Epithelium in the Human Fallopian Tube

There is a growing body of evidence regarding cell competition between normal and mutant mammalian cells, which suggest that it may play a defensive role in the early phase of carcinogenesis. In vitro study in the past has shown that overexpression of vimentin in normal epithelial cells at the contact surface with transformed cells is essential for the cell competition involved...

Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade

Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity. The new clusters of adipocytes that emerge with WAT browning have been named ‘beige’ or ‘brite’ adipocytes. Recent reports have indicated that the renin...

Computational awareness towards green environments

This special issue calls for high quality and state-of-the-art research issues and results concerning the development of green environment from the perspective of computing systems. In particular, the special issue is going to showcase the most recent achievements and developments in the realm of awareness computing. Original and research articles are solicited in all aspects of...

Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice

Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the brain and blood of Parkinson’s disease (PD) patients. The present study investigated the hypothesis that augmenting plasmalogens could protect striatal dopamine neurons that degenerate in response to 1-methyl-4-phenyl-1,2,3,6...

ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo

Vascular smooth muscle cell (VSMC) proliferation and migration are pivotal for the pathogenesis of atherosclerosis and post-angioplasty restenosis. We have recently reported that a disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7), a novel metalloproteinase, contributes directly to neointima formation by mediating VSMC migration. However, whether ADAMTS-7...

Persistently high prevalence of primary resistance and multidrug resistance of tuberculosis in Heilongjiang Province, China

Background The spread of multidrug-resistant tuberculosis (MDR-TB) Mycobacterium tuberculosis (M. tuberculosis) strains has been a big challenge to the TB control and prevention in China. Knowledge about patterns of drug resistance in TB high-burden areas of China is crucial to develop appropriate control strategies. We conducted a comprehensive investigation of the resistance...

Angiotensin II type 2 receptor signaling affects dopamine levels in the brain and prevents binge eating disorder

Introduction: Binge eating disorder (BED) is associated with dopaminergic activation as food reward, resulting in metabolism-related disorders. Stimulation of angiotensin type 2 (AT2) receptor is reported to inhibit dopamine synthesis. We investigated the possible roles of AT2 receptor-mediated dopamine regulation in the pathogenesis of BED.

The rise of the Himalaya enforced the diversification of SE Asian ferns by altering the monsoon regimes

Background The rise of high mountain chains is widely seen as one of the factors driving rapid diversification of land plants and the formation of biodiversity hotspots. Supporting evidence was reported for the impact of the rapid rise of the Andean mountains but this hypothesis has so far been less explored for the impact of the “roof of the world”. The formation of the Himalaya...

Engineered Zymomonas mobilis for salt tolerance using EZ-Tn5-based transposon insertion mutagenesis system

Background The cell growth and ethanol yield of Zymomonas mobilis may be detrimentally affected by salt stress frequently present in some biomass-based fermentation systems, leading to a decrease in the rate of sugar conversion to ethanol or other bioproducts. To address this problem, improving the salt tolerance of Z. mobilis is a desirable way. However, limited progress has...

Drinking Citrus Fruit Juice Inhibits Vascular Remodeling in Cuff-Induced Vascular Injury Mouse Model

Citrus fruits are thought to have inhibitory effects on oxidative stress, thereby attenuating the onset and progression of cancer and cardiovascular disease; however, there are few reports assessing their effect on vascular remodeling. Here, we investigated the effect of drinking the juice of two different citrus fruits on vascular neointima formation using a cuff-induced...

Parent-reported health care expenditures associated with autism spectrum disorders in Heilongjiang province, China

Background The aim of this study was to determine the health expenses incurred by families with children with autism spectrum disorder (ASD) and those expenses' relation to total household income and expenditures. Methods In this cross-sectional study, health care expenditure data were collected through face-to-face interviews. Expenses included annual costs for clinic visits...

Cell Cycle Gene Networks Are Associated with Melanoma Prognosis

Background Our understanding of the molecular pathways that underlie melanoma remains incomplete. Although several published microarray studies of clinical melanomas have provided valuable information, we found only limited concordance between these studies. Therefore, we took an in vitro functional genomics approach to understand melanoma molecular pathways. Methodology...

Mitochondria-Targeted Superoxide Dismutase (SOD2) Regulates Radiation Resistance and Radiation Stress Response in HeLa Cells

Ayaka HOSOKI Shin-Ichiro YONEKURA Qing-Li ZHAO Zheng-Li WEI Ichiro TAKASAKI Yoshiaki TABUCHI Li-Li WANG Shiga HASUIKE Takaharu NOMURA Akira TACHIBANA Kazunari HASHIGUCHI Shuji YONEI Takashi KONDO Qiu

Genetic Structure of a 2,500-Year-Old Human Population in China and Its Spatiotemporal Changes

To examine temporal changes in population genetic structure, we compared the mitochondrial DNA (mtDNA) sequences of three populations that lived in the same location, Linzi, China, in different periods: 2,500 years ago (the Spring–Autumn era), 2,000 years ago (the Han era), and the present day. Two indices were used to compare the genetic differences: the frequency distributions...