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Prenatal perfluorooctanoic acid exposure and glutathione s-transferase T1/M1 genotypes and their association with atopic dermatitis at 2 years of age

. Visualization: Hui-Ju Wen. Writing ? original draft: Hui-Ju Wen. Writing ? review & editing: Shu-Li Wang, Yue Leon Guo. 11 / 14 12 / 14 20. Wen HJ, Wang YJ, Lin YC, Chang CC, Shieh CC, Lung FW, et al

Identification and trichothecene genotypes of Fusarium graminearum species complex from wheat in Taiwan

Background Fusarium head blight (FHB) of wheat caused by Fusarium graminearum species complex (FGSC) is a devastating disease worldwide. The pathogens not only reduce the yield of wheat, but also impact the quality of wheat by contamination with trichothecene mycotoxins. A systematic investigation on the pathogens of FHB in Taiwan is lacking. Here, molecular and morphological...

An Improved Tax Scheme for Selfish Routing

We study the problem of routing traffic for independent selfish users in a congested network to minimize the total latency. The inefficiency of selfish routing motivates regulating the flow of the system to lower the total latency of the Nash Equilibrium by economic incentives or penalties. When applying tax to the routes, we follow the definition of [Christodoulou et al...

Effect of national pre-ESRD care program on expenditures and mortality in incident dialysis patients: A population-based study

-for-performance program in Taiwan. (DOCX) Author Contributions Conceptualization: Ming-Yen Lin, Li-Jen Cheng, Yi-Wen Chiu, Hui-Min Hsieh, Ping-Hsun Wu, Yi-Ting Lin, Shu-Li Wang, Chih Cheng Hsu, Shang ... -Jyh Hwang. Formal analysis: Yi-Ting Lin, Feng-Xuan Jian, Shu-An Yang, Huei-Lan Lee. Methodology: Ming-Yen Lin, Yi-Wen Chiu, Hui-Min Hsieh, Ping-Hsun Wu, Shu-Li Wang, Feng-Xuan Jian, Shu-An Yang, Huei

MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells

Chronic myeloid leukemia (CML) is a myeloproliferative disease. Imatinib (IM), the first line treatment for CML, is excessively expensive and induces various side effects in CML patients. Therefore, it is essential to investigate a new strategy for improving CML therapy. Our immunoblot data revealed that RanGTPase activating protein 1 (RanGAP1) protein levels increased by...

Modeling the Pulse Signal by Wave-Shape Function and Analyzing by Synchrosqueezing Transform

We apply the recently developed adaptive non-harmonic model based on the wave-shape function, as well as the time-frequency analysis tool called synchrosqueezing transform (SST) to model and analyze oscillatory physiological signals. To demonstrate how the model and algorithm work, we apply them to study the pulse wave signal. By extracting features called the spectral pulse...

17-DMAG, an HSP90 Inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats

Sepsis is a systemic inflammatory disorder, accompanied with elevated oxidative stress, leading to multiple organ dysfunction syndrome (MODS), and disseminated intravascular coagulation. 17-Dimethylaminoethylamino- 17-demethoxygeldanamycin (17-DMAG), a heat shock protein (HSP) 90 inhibitor, has been reported to possess anti-inflammatory effects. In this study, the beneficial...

Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – Phthalate contaminated-foodstuff episode in Taiwan

study. RAPIT study members include Chao A. Hsiung (coordinating principal investigator, , Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan), Shu-Li Wang

A preliminary study on instructional design of Chinese input method for blind students

-consciousness) tia¯n xia` (World) shu` xia` (Under the tree) bu` chˇı xia` we`n (Always ask questions) 下glyph = (like the letters T lower right corner to add a dot). Jan-Li Wang is a Research Fellow, and his

The Giant Mottled Eel, Anguilla marmorata, Uses Blue-Shifted Rod Photoreceptors during Upstream Migration

Catadromous fishes migrate between ocean and freshwater during particular phases of their life cycle. The dramatic environmental changes shape their physiological features, e.g. visual sensitivity, olfactory ability, and salinity tolerance. Anguilla marmorata, a catadromous eel, migrates upstream on dark nights, following the lunar cycle. Such behavior may be correlated with...

Intake of Phthalate-tainted Foods and Serum Thyroid Hormones in Taiwanese Children and Adolescents

-Lien Chen in:Nature Research journals • PubMed • Google ScholarSearch for Shu-Li Wang in:Nature Research journals • PubMed • Google ScholarSearch for Bai-Hsiun Chen in:Nature Research journals • PubMed

Risk of Developing Depressive Disorders following Rheumatoid Arthritis: A Nationwide Population-Based Study

Background & Aims To evaluate the risk of depressive disorders among rheumatoid arthritis (RA) by using the Taiwan National Health Insurance Research Database (NHIRD). Methods We conducted a retrospective study of a matched cohort of 18 285 participants (3 657 RA patients and 14 628 control patients) who were selected from the NHIRD. Patients were observed for a maximum of 10...

Association of Fluid Status and Body Composition with Physical Function in Patients with Chronic Kidney Disease

Background Impairment of physical function and abnormal body composition are the major presentations in patients with chronic kidney disease (CKD). The aim of this study is to investigate the relationship between body composition and physical function in CKD patients. Methods This cross-sectional study enrolled 172 of CKD stages 1–5 from February 2013 to September 2013. Handgrip...

Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons

Background Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmission and causes hyperalgesia remain unknown. The substantia...

Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer

-Li Wang 0 Peter McKinnon, St Jude Children's Research Hospital, United States of America 0 1 Departments of Pathology and Gynecology/Obstetrics, The Johns Hopkins University School of Medicine

Fetal and Childhood Exposure to Phthalate Diesters and Cognitive Function in Children Up to 12 Years of Age: Taiwanese Maternal and Infant Cohort Study

Taiwan for their assistance in data and specimen collection. Members of Taiwan Maternal and Infant Cohort Study (TMICS) group include Shu-Li Wang (Study Coordinating Principle Investigator), Ming-Tsang Wu

An Antimitotic and Antivascular Agent BPR0L075 Overcomes Multidrug Resistance and Induces Mitotic Catastrophe in Paclitaxel-Resistant Ovarian Cancer Cells

Paclitaxel plays a major role in the treatment of ovarian cancer; however, resistance to paclitaxel is frequently observed. Thus, new therapy that can overcome paclitaxel resistance will be of significant clinical importance. We evaluated antiproliferative effects of an antimitotic and antivascular agent BPR0L075 in paclitaxel-resistant ovarian cancer cells. BPR0L075 displays...

Sex Steroid Hormone Levels and Reproductive Development of Eight-Year-Old Children following In Utero and Environmental Exposure to Phthalates

In utero exposure to phthalates may adversely affect reproductive development in children due to the anti-androgenic properties of the pthalates. Accordingly, we aimed to determine the effects of in utero and environmental phthalate exposure on the reproductive development of eight-year-old children. We recruited 180 children in central Taiwan during November 2001 and followed...

Prenatal and Postnatal Exposure to Phthalate Esters and Asthma: A 9-Year Follow-Up Study of a Taiwanese Birth Cohort

using SPSS 17.0 software (Chicago, IL, USA). Hsiu-Ying Ku, Hui-Ju Wen, and Shu-Li Wang had full access to all data in this study and took responsibility for the integrity of the data and accuracy of the ... of TMICS is Shu-Li Wang (Coordinating Principle Investigator, PI), Mei-Lien Chen, Ming-Tsang Wu, and Chia-Jung Hsieh (PIs). Conceived and designed the experiments: HYK SLW TMICS Group. Performed the