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Preclinical evaluation of the efficacy, pharmacokinetics and immunogenicity of JS-001, a programmed cell death protein-1 (PD-1) monoclonal antibody

the research; Jie FU, Hui Feng, Bo CHEN, Li-hou DONG, Xue-li WANG, and Xin-yao XIE analyzed the data; Jie FU, Fang WANG, and Hai-feng SONG wrote the paper. References 1. McDermott DF, Atkins MB. PD ... Radiation Medicine, Beijing 100850, China;Jie Fu, Fang Wang, Li-hou Dong & Hai-feng SongUnited-Power Pharma Tech Co, Ltd, Beijing 102206, China;Jing Zhang, Cheng-lian Deng, Xue-li Wang & Xin-yao XieShanghai

Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats

Funds from Auburn University College of Veterinary Medicine. Author contribution Li-li WANG performed most of the experiments/data analysis and drafted the manuscript; Dori MILLER participated in most

The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability

tested compounds. Yu-lei LI and Chen-ling PAN performed the research. Guan-lin WANG, Pei-lan ZHOU, Li-li WANG, and Gang YU participated in experimental design. Ze-hui GONG, Rui-bin SU, and Gang YU revised

Co-activation of nAChR and mGluR induces γ oscillation in rat medial septum diagonal band of Broca slices

contribution Ya-li WANG performed the experiments, analyzed the data and wrote the paper; Jian-gang WANG analyzed the data; Gao-xiang OU-YANG analyzed the data; Xiao-li LI analyzed the data; Z HENDERSON

Lipid metabolism disturbances and AMPK activation in prolonged propofol-sedated rabbits under mechanical ventilation

ZHOU 0 Xiang HUAN 0 Li WANG 0 0 Department of Anesthesiology, Shanghai Sixth Municipal Hospital, Shanghai Jiaotong University , Shanghai 200233 , China Aim: To explore the mechanisms underlying the ... this rabbit model. Acknowledgements This study was supported by a grant from Shanghai Sixth Hospital. Author contribution Li WANG designed research and wrote the paper; Wei JIANG performed research

Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway

, Man-hong LI, Ji-ping TANG, Chun-yan WANG, and Wei ZOU performed the research; Hai-jun WEI, Li WANG, Manhong LI, and Ji-ping TANG analyzed the data; and Xiao-qing TANG and Ping ZHANG wrote the paper. npg

Population pharmacokinetics modeling of levetiracetam in Chinese children with epilepsy

Aim:To establish a population pharmacokinetics (PPK) model of levetiracetam in Chinese children with epilepsy.Methods:A total of 418 samples from 361 epileptic children in Peking University First Hospital were analyzed. These patients were divided into two groups: the PPK model group (n=311) and the PPK validation group (n=50). Levetiracetam concentrations were determined by HPLC...

Rosiglitazone protects neuroblastoma cells against advanced glycation end products-induced injury

manuscript; Dr Li WANG performed metabolism[ 28?30 ]. Sastre and colleagues[ 30 ] reported that PPAR? the experiments; Dr Wei LIU assisted with the experiments; agonists modulate the processing of APP

The efficacy and safety of weekly 35-mg risedronate dosing regimen for Chinese postmenopausal women with osteoporosis or osteopenia: 1-year data

oral dosing options, from daily to weekly. Acknowledgements This study was sponsored by Kunming Jida Pharmaceutical Co, Ltd, Kunming, China. npg Author contribution Zhen-lin ZHANG, Li WANG, Hua LIN ... , De-cai CHEN, Hai TANG, Xiao-lan JIN, and Wei-bo XIA designed research; Jiemei GU, Li WANG, Hua LIN, De-cai CHEN, Hai TANG, Xiaolan JIN, Wei-bo XIA, Yun-qiu HU, Wen-zhen FU, Jin-wei HE, Hao ZHANG, Chun

Population pharmacokinetics of lamotrigine in Chinese children with epilepsy

). Author information Author notesDa-ke He & Li Wang These two authors contributed equally to this article. AffiliationsDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, ChinaDa-ke ... He, Li Wang & Jiong QinDepartment of Pediatrics, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaDa-ke He, Ling Li, Jian-ming Zhang, Wei-qun Bao

siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

AM , Twining SS , Warejcka DJ , Tall E , Masur SK . Urokinase conception and design of the research. Yan-ping ZHANG, receptor cleavage: a crucial step in fibroblast-to-myofibroblast differenWei-li WANG ... , and Jian LIU performed the experiments; Wei- tiation . Mol Bio Cell 2007 ; 18 : 2716 - 27 . li WANG and Lin-lin BAI analysed the data; Ya-dong YUAN 18 Hu PF , Chen H , Zhong W , Lin Y , Zhang X , Chen

Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells

treatment modality has the potential to improve the anticancer efficacy of cDDP. Author contribution Shuang-shuang WU and Jian-qing WU designed the research; Shuang-shuang WU, Wei XU, Xue-li WANG, Yan ... Wu, Wei Xu, Shan Liu, Bo Chen, Xue-li Wang, Yan Wang, Shi-feng Liu & Jian-qing Wu AuthorsSearch for Shuang-shuang Wu in:Nature Research journals • PubMed • Google ScholarSearch for Wei Xu in:Nature

Liraglutide reduces the body weight and waist circumference in Chinese overweight and obese type 2 diabetic patients

Research journals • PubMed • Google ScholarSearch for Su-li Wang in:Nature Research journals • PubMed • Google ScholarSearch for Hong-tao Li in:Nature Research journals • PubMed • Google ScholarSearch for

Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles

research; Xi-ming XU, Yuan ZHU, and Li WANG analyzed data; Li WANG wrote the paper. npg 14th World Society of Pain Clinicians Congress (WSPC 2010) Website: 1 Sallee VL , Dietschy

Population pharmacokinetics of valproate in Chinese children with epilepsy

Aim:The aim of the present study is to establish a population pharmacokinetic (PPK) model of valproate (VPA) in Chinese epileptic children to promote the reasonable use of anti-epileptic drugs.Methods:Sparse data of VPA serum concentrations from 417 epileptic children were collected. These patients were divided into 2 groups: the PPK model group (n=317) and the PPK valid group (n...

Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway

liver cancer. Author contribution Qian WANG designed research; Liang-qi CAO and Xiao-li WANG performed research; Ping XUE, Xing-yuan JIAO, He-ping PENG, Hai-wu LU, and Qiang ZHENG contributed new ... and equipment. Author information Author notesLiang-qi Cao & Xiao-li Wang These authors contributed equally to this work. AffiliationsDepartment of Hepatobiliary Surgery, the First Affiliated