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NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton

STUDY QUESTION What is the subcellular localization in human oocytes and preimplantation embryos, of the two maternal-effect proteins, NLRP7 and KHDC3L, responsible for recurrent hydatidiform moles (RHMs)?

Use of autocorrelation scanning in DNA copy number analysis

Liangcai Zhang 0 1 Li Zhang 1 Associate Editor: Janet Kelso 0 Department of Biophysics, College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081

A revisit of gamma-ray luminosity function and contribution to the extragalactic diffuse gamma-ray background for Fermi FSRQs

A clean sample of flat-spectrum radio quasars (FSRQs) has been provided by Fermi Large Area Telescope (LAT) in two years of operation. Based on this sample, we reconstruct the gamma-ray luminosity function (GLF) in the framework of the luminosity-dependent density evolution (LDDE) model, and obtain the best-fitting GLF by comparing the distributions of observed redshifts...

Integrating multiple resources to identify specific transcriptional cooperativity with a Bayesian approach

Motivation: Limited cohort of transcription factors is capable to structure various gene-expression patterns. Transcriptional cooperativity (TC) is deemed to be the main mechanism of complexity and precision in regulatory programs. Although many data types generated from numerous experimental technologies are utilized in an attempt to understand combinational transcriptional...

Non-variable TeV emission from the extended jet of a blazar in the stochastic acceleration scenario: the case of the hard TeV emission of 1ES 1101–232

The detections of X-ray emission from the kiloparsec-scale jets of blazars and radio galaxies could imply the existence of high-energy electrons in these extended jets, and these electrons could produce high-energy emission through the inverse Compton (IC) process. In this paper, we study the non-variable hard TeV emission from a blazar. The multiband emission consists of two...

CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation

Pituitary-secreted luteinizing hormone (LH) induces ovulation by activating an extracellular regulated kinase 1/2 (ERK1/2) cascade. However, little is known regarding the ERK1/2 downstream effectors that are involved in regulating rapid, transient expression of LH-target gene in ovulatory follicles. By comparing the gene expression profiles of LH-stimulated wild type with ERK1/2...

Contribution from blazar cascade emission to the extragalactic gamma-ray background: what role does the extragalactic magnetic field play?

We estimate the contribution to the extragalactic gamma-ray background (EGRB) from both intrinsic and cascade emissions produced by blazars, using a simple semi-analysis method for two models of the blazar gamma-ray luminosity function (GLF). For the cascade emission, we consider two possible contributions: in case I, the flux of the cascade emission is lower than the Fermi Large...

Activation of the Nrf2-ARE Pathway in Hepatocytes Protects Against Steatosis in Nutritionally Induced Non-alcoholic Steatohepatitis in Mice

Oxidative stress is implicated in the development of non-alcoholic steatohepatitis (NASH). The Nrf2-antioxidant response element pathway protects cells from oxidative stress. Studies have shown that global Nrf2 deficiency hastens the progression of NASH. The purpose of this study was to determine whether long-term hepatocyte-specific activation of Nrf2 mitigates NASH progression...

Comparative Genomics Suggests That an Ancestral Polyploidy Event Leads to Enhanced Root Nodule Symbiosis in the Papilionoideae

Root nodule symbiosis (RNS) is one of the most efficient biological systems for nitrogen fixation and it occurs in 90% of genera in the Papilionoideae, the largest subfamily of legumes. Most papilionoid species show evidence of a polyploidy event that occurred approximately 58 Ma. Although polyploidy is considered to be an important evolutionary force in plants, the role of this...

On the non-thermal emission from the supernova remnant W51C

Jun Fang 0 Li Zhang 0 0 Department of Physics, Yunnan University , Kunming, China A B S T R A C T The middle-aged supernova remnant W51C is an interesting source because of the interaction of the

PurityEst: estimating purity of human tumor samples using next-generation sequencing data

Summary: We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing datasets and demonstrated the accuracy of PurityEst compared...

Estrogen promotes the growth of decidual stromal cells in human early pregnancy

Interleukin-24 (IL-24) is a novel tumor suppressor gene, which has suppressor activity in a broad spectrum of human cancer cells. The present study aimed to elucidate the biological function of IL-24 and its receptors (IL-20R1, IL-20R2 and IL-22R1) in decidual stromal cells (DSCs) at human maternal–fetal interface. The DSCs behaviors in vitro were verified by viability (MTT, 3-(4...

Comprehensive insights on how 2,4-dichlorophenoxyacetic acid retards senescence in post-harvest citrus fruits using transcriptomic and proteomic approaches

Auxin-like 2,4-dichlorophenoxyacetic acid (2,4-D), a high-efficiency anti-stalling agent for the post-harvest fresh fruit industry, has had its use restricted due to environmental concerns. However, no other substitutes for 2,4-D are available to the post-harvest industry. Insights into the molecular mechanism underlying the effects of 2,4-D on fruit quality preservation will...

Comparative analysis of somatic copy-number alterations across different human cancer types reveals two distinct classes of breakpoint hotspots

Somatic copy-number alterations (SCNAs) play a crucial role in the development of human cancer. However, it is not well understood what evolutionary mechanisms contribute to the global patterns of SCNAs in cancer genomes. Taking advantage of data recently available through The Cancer Genome Atlas, we performed a systematic analysis on genome-wide SCNA breakpoint data for eight...

Non-thermal emission from old supernova remnants

We study the non-thermal emission from old shell-type supernova remnants (SNRs) on the frame of a time-dependent model. In this model, the time-dependent non-thermal spectra of both primary electrons and protons as well as secondary electron/positron (e±) pairs can be calculated numerically by taking into account the evolution of the secondary e± pairs produced from proton–proton...

Four-dimensional CT-based evaluation of volumetric modulated arc therapy for abdominal lymph node metastasis from hepatocellular carcinoma

This study aimed to identify the potential benefits and limitations of a new volumetric modulated arc therapy (VMAT) planning system in Monaco, compared with conventional intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT). Four-dimensional CT scans of 13 patients with abdominal lymph node metastasis from hepatocellular carcinoma were...

Enhanced Radiosensitivity in 1,25-dihydroxyvitamin D3 Deficient Mice

Zeng-Li ZHANG Xiao-Fei DING Jian TONG Bing-Yan LI Radiosensitivity/Knockout mice/1,25-(OH)2D3/Osteogenesis/Hematopoiesis. To investigate whether impaired osteogenesis resulting from vitamin D

Religious beliefs influence neural substrates of self-reflection in Tibetans

Previous transcultural neuroimaging studies have shown that the neural substrates of self-reflection can be shaped by different cultures. There are few studies, however, on the neural activity of self-reflection where religion is viewed as a form of cultural expression. The present study examined the self-processing of two Chinese ethnic groups (Han and Tibetan) to investigate...

A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations

Vaccination against hepatitis B virus is an effective and routine practice that can prevent infection. However, 5–10% of healthy adults fail to produce protective levels of antibody against the hepatitis B vaccination. It has been reported that host genetic variants might affect the immune response to hepatitis B vaccination. Here, we reported a genome-wide association study in a...

Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits

Trisomy 21 (Down syndrome, DS) is the most common genetic cause of developmental cognitive deficits, and the so-called Down syndrome critical region (DSCR) has been proposed as a major determinant of this phenotype. The regions on human chromosome 21 (Hsa21) are syntenically conserved on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. DSCR is conserved between the Cbr1 and Fam3b...