Advanced search    

Search: authors:"Li Zhang"

333 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Hypofractionated radiotherapy as a salvage treatment for recurrent hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombus: a multi-center analysis

Recurrent hepatocellular carcinoma (HCC) with a tumor thrombus (TT) extending into the inferior vena cava (IVC)/right atrium (RA) is generally regarded as a terminal-stage condition and there is no worldwide consensus on the proper management of this situation. In the present study, we report the efficacy of hypofractionated radiotherapy (HFRT) as a salvage treatment for...

H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

of Physiology and Neurobiology, Institute for Systems Genomics, University of Connecticut, Storrs, CT, 06269, USAJianguo Wu AuthorsSearch for Li Zhang in:Nature Research journals • PubMed • Google

GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway

Gastric cancer is one of the deadliest malignant tumours, with a high incidence in China, and is regulated by aberrantly overexpressed oncogenes. However, existing therapies are insufficient to meet patients’ needs; thus, the identification of additional therapeutic targets and exploration of the underlying mechanism are urgently needed. GPAA1 is the subunit of the GPI...

The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1

Cervical cancer is a malignancy that’s common in female with high incidence and mortality worldwide. MicroRNAs (miRNAs) act a pivotal part in human cancer development. Our aim was to investigate the effect of miR-126 on cervical cancer and its underlying molecular mechanism. Firstly, RT-qPCR assay revealed that the expression of miR-126 was significantly downregulated in cervical...

Which is the optimal immunotherapy for advanced squamous non-small-cell lung cancer in combination with chemotherapy: anti-PD-1 or anti-PD-L1?

Recent randomized phase III trials (KEYNOTE-407 and IMpower131) reported that adding anti-programmed death (ligand) 1 (anti-PD-(L)1) antibodies in combination with taxane-platinum improve the therapeutic efficacy for advanced squamous non-small-cell lung cancer (NSCLC). However, there is no head-to-head comparison of pembrolizumab (anti-PD-1) plus chemotherapy vs. atezolizumab...

The value of oral contrast ultrasonography in the diagnosis of gastric cancer in elderly patients

This study aims to investigate the value of oral contrast ultrasonography (OCUS) in the diagnosis of gastric cancer in elderly patients. OCUS data obtained from patients ≥ 60 years old were retrospectively analyzed and compared with gastroscopy results. Among the 12,716 subjects examined by OCUS, 5021 subjects were ≥ 60 years old, which accounted for 39.48% (5021/12,716...

Postnatal length and weight growth velocities according to Fenton reference and their associated perinatal factors in healthy late preterm infants during birth to term-corrected age: an observational study

Optimum early postnatal growth is critical for early and later health of preterm infants. Postnatal length and weight growth velocities and their associated perinatal factors in healthy late preterm infants without restriction of neonatal complications and nutritional problems have not been widely studied. As part of ongoing longitudinal follow-up study of growth and development...

Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

Foundation of China (#81502202 to Si-si Wang). Li Zhang is the Inaugural Maria H. Bacardi Chair in Transplantation. Ming-Sound Tsao is the M. Qasim Choksi Chair in Lung Cancer Translational Research ... , University Health Network. Consent for publication All authors consent for publication. Competing interests Li Zhang is one of the inventors on 7 DNT cell technology-related patents and serves as a

Identification of cucumber circular RNAs responsive to salt stress

Circular RNAs (circRNAs) are 3′-5′ head-to-tail covalently closed non-coding RNA that have been proved to play essential roles in many cellular and developmental processes. However, no information relate to cucumber circRNAs is available currently, especially under salt stress condition. In this study, we sequenced circRNAs in cucumber and a total of 2787 were identified, with...

The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells

Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex that plays an important role in hematopoietic differentiation. Therefore, we hypothesize that Notch1 might regulate the NF-κB pathway through Asb2α. The study involved down...

Effects of naphthalene on soil fauna abundance and enzyme activity in the subalpine forest of western Sichuan, China

Naphthalene has been widely used to study the role of soil fauna, but its potential non-target effects on soil enzyme activity remain unknown in subalpine forests. We added naphthalene for two years and determined the effect of such additions on the abundance of soil fauna and soil enzyme activities (β-glucosidase, cellobiohydrolase, invertase, peroxidase, polyphenol oxidase, N...

Comparative transcriptomic profiling of peripheral efferent and afferent nerve fibres at different developmental stages in mice

Peripheral nerve injury impairs motor and sensory function in humans, and its functional recovery largely depends on the axonal outgrowth required for the accurate reinnervation of appropriate targets. To better understand how motor and sensory nerve fibres select their terminal pathways, an unbiased cDNA microarray analysis was conducted to examine differential gene expression...

Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

manuscript. Funding This work was supported by the Canadian Cancer Society Research Institute Impact grant and Canadian Institutes of Health Research grant (to Li Zhang) and the Ontario Research Fund ... Research Excellence (ORF-RE) grant (RE-03-020; to Ming-Sound Tsao). Li Zhang is the Inaugural Maria H. Bacardi Chair in Transplantation and Ming-Sound Tsao is the M. Qasim Choksi Chair in Lung Cancer

Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population

The present study evaluated the predictive ability of five known “best” obesity and lipid-related parameters, including body mass index (BMI), waist-to-height ratio (WHtR), triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C), lipid accumulation product (LAP) and visceral adiposity index (VAI), in identifying metabolic syndrome (MetS) in Chinese elderly population. A...

Interference with lactate metabolism by mmu-miR-320-3p via negatively regulating GLUT3 signaling in mouse Sertoli cells

Disruption of the nursery function in Sertoli cells (SCs) by reducing lactate production, a preferred energy substrate for developed germ cells (spermatocytes and spermatids), is tightly associated with spermatogenic failure such as SC-only syndrome (SCOS). However, whether this complicated pathogenesis is regulated by certain miRNAs at the post-transcriptional level remain...

Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

Ischaemia reperfusion (IR) induces multiple pathophysiological changes. In addition to its classical role in regulating tumourigenesis, the feedback loop formed by p53 and its driven target p53-upregulated modulator of apoptosis (PUMA) was recently demonstrated to be the common node tightly controlling various cellular responses during myocardial IR. However, the roles of the p53...

Immune-checkpoint inhibitor plus chemotherapy versus conventional chemotherapy for first-line treatment in advanced non-small cell lung carcinoma: a systematic review and meta-analysis

interests Li Zhang has received research support from AstraZeneca, Eli Lilly and company, and Roche. No other disclosures were reported. Publisher’s Note Springer Nature remains neutral with regard to

MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway

Research journals • PubMed • Google Scholar Search for Fuqian He in:Nature Research journals • PubMed • Google Scholar Search for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for ... Liu analyzed the data and wrote the paper; Fuqian He & Li Zhang contributed to the gene transfection; Kun Yang, Huan Yu & Jinqiu Zhou helped to isolate the colon myenteric plexus and immunofluorescence

Immunization with a suicidal DNA vaccine expressing the E glycoprotein protects ducklings against duck Tembusu virus

Duck Tembusu virus (DTMUV), a pathogenic flavivirus, emerged in China since 2010 and causing huge economic loss in the Chinese poultry industry. Although several vaccines have been reported to control DTMUV disease, few effective vaccines are available and new outbreaks were continuously reported. Thus, it is urgently to develop a new effective vaccine for prevention of this...

Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

While conventional chemotherapy is effective at eliminating the bulk of leukemic cells, chemotherapy resistance in acute myeloid leukemia (AML) is a prevalent problem that hinders conventional therapies and contributes to disease relapse, and ultimately patient death. We have recently shown that allogeneic double negative T cells (DNTs) are able to target the majority of primary...