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28 papers found.
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Improved simulation of carbon and water fluxes by assimilating multi-layer soil temperature and moisture into process-based biogeochemical model

BackgroundSoil temperature and moisture are sensitive indicators in soil organic matter decomposition because they control global carbon and water cycles and their potential feedback to climatic variations. Although the Biome-Biogeochemical Cycles (Biome-BGC) model is broadly applied in simulating forest carbon and water fluxes, its single-layer soil module cannot represent...

Expression of cancer–testis antigens in esophageal cancer and their progress in immunotherapy

PurposeEsophageal cancer is a common disease in China with low survival rate due to no obvious early symptoms and lack of effective screening strategies. Traditional treatments usually do not produce desirable results in patients with advanced esophageal cancer, so immunotherapy which relies on tumor-related antigens is needed to combat low survival rates effectively. Cancer...

Validity of parameter optimization in improving MJO simulation and prediction using the sub-seasonal to seasonal forecast model of Beijing Climate Center

Using the sub-seasonal to seasonal forecast model of Beijing Climate Center, several key physical parameters are perturbed by the Latin hypercube sampling method to find a better configuration for representation of Madden–Julian oscillation (MJO) in the free-run simulation. We find that although model simulation is especially sensitive to some parameters, there are overall no...

Correction to: A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors

Zhang 0 0 Department of Biological Sciences, University of Texas at Dallas , Mail Stop RL11, 800 W, Campbell Road, Richardson, TX 75080 , USA Texas) Grant RP160617. - In this Correction, the authors

Computational Analysis of Artimisinin Derivatives on the Antitumor Activities

The study on antitumor activities of artemisinin and its derivatives has been closely focused on in recent years. Herein, 2D and 3D QSAR analysis was performed on the basis of a series of artemisinin derivatives with known bioactivities against the non-small-cell lung adenocarcinoma A549 cells. Four QSAR models were successfully established by CoMSIA, CoMFA, topomer CoMFA and...

First-line afatinib vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients who continued treatment beyond progression

PurposeIn the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer. We report post hoc analyses of tolerability-guided dose adjustment for afatinib and summarize the clinical...

Characterizing dynamic behaviors of three-particle paramagnetic microswimmer near a solid surface

Particle-based magnetically actuated microswimmers have the potential to act as microrobotic tools for biomedical applications. In this paper, we report the dynamic behaviors of a three-particle paramagnetic microswimmer. Actuated by a rotating magnetic field with different frequencies, the microswimmer exhibits simple rotation and propulsion. When the input frequency is below 8...

Integrated generation–consumption dispatch based on compensation mechanism considering demand response behavior

operation optimization and control . Li ZHANG received the B .E. degree from Tianjin University, Tianjin, China, in 1989 , and the M.E. and Ph .D. degrees from the Shandong University of Technology and

A CuNi/C Nanosheet Array Based on a Metal–Organic Framework Derivate as a Supersensitive Non-Enzymatic Glucose Sensor

Bimetal catalysts are good alternatives for non-enzymatic glucose sensors owing to their low cost, high activity, good conductivity, and ease of fabrication. In the present study, a self-supported CuNi/C electrode prepared by electrodepositing Cu nanoparticles on a Ni-based metal–organic framework (MOF) derivate was used as a non-enzymatic glucose sensor. The porous construction...

Application of momentum backpropagation algorithm (MOBP) in identification of low-resistivity pay zones in sandstones

Low-resistivity pay zones with substantial reserves in many oilfields around the world are drawing more attention than ever before. Through analyzing the features of the logging data in low-resistivity pay zones, a fast model for identification of low-resistivity pay zones was developed in this paper. Momentum backpropagation algorithm was used in the model development...

Minimally invasive versus open transforaminal lumbar fusion: a systematic review of complications

Purpose The aim of this study is to compare mTLIF vs. oTLIF with regard to peri-operative complications, operative time, estimated blood loss, fluoroscopic time, and the length of hospital stay. Methods The PubMed and EMBASE databases were searched for relevant articles reporting patients undergoing TLIF, and a comparison between mTILF and oTLIF was performed. The database...

Acausality in nonlocal gravity theory

We investigate the nonlocal gravity theory by deriving nonlocal equations of motion using the traditional variation principle in a homogeneous background. We focus on a class of models with a linear nonlocal modification term in the action. It is found that the resulting equations of motion contain the advanced Green’s function, implying that there is an acausality problem. As a...

A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors

Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in the 1920s, many scientists have tried to further the understanding of tumor bioenergetics. Particularly, in the past decade, the application of the state-of the-art metabolomics and genomics technologies has revealed the remarkable plasticity of tumor metabolism and...

Service workload patterns for Qos-driven cloud resource management

Cloud service providers negotiate SLAs for customer services they offer based on the reliability of performance and availability of their lower-level platform infrastructure. While availability management is more mature, performance management is less reliable. In order to support a continuous approach that supports the initial static infrastructure configuration as well as...

An evaluation of boreal summer intra-seasonal oscillation simulated by BCC_AGCM2.2

The intra-seasonal oscillation (ISO) is a prominent feature of the East Asia summer monsoon. The Beijing Climate Center model is one of the IPCC models participating in the Coupled Model Inter-comparison Project (CMIP) 3 and CMIP5 experiments. This paper presents a systematic evaluation of ISO simulated by the Beijing Climate Center atmospheric general circulation model version 2...

Homogeneous instantons in bigravity

We study homogeneous gravitational instantons, conventionally called the Hawking-Moss (HM) instantons, in bigravity theory. The HM instantons describe the amplitude of quantum tunneling from a false vacuum to the true vacuum. Corrections to General Relativity (GR) are found in a closed form. Using the result, we discuss the following two issues: reduction to the de Rham-Gabadadze...

KRAS mutation-induced upregulation of PD-L1 mediates immune escape in human lung adenocarcinoma

It was reported that PD-L1 expression was correlated with genetic alterations. Whether PD-L1 was regulated by mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) in non-small-cell lung cancer (NSCLC) and the underlying molecular mechanism were largely unknown. In this study, we investigated the correlation between PD-L1 expression and KRAS mutation and the functional...