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The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy

MK-8776 is a recently described inhibitor that is highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies show that MK-8776 enhances the cytotoxicity of hydroxyurea and gemcitabine without increasing normal tissue toxicities. Thus far, there is no evidence that MK-8776 can be...

Efficacy-oriented compatibility for component-based Chinese medicine

Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and “polypills”, as the frontier in new drug development. A traditional Chinese medicine (TCM) prescription that is usually...

A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer

One of the major goals of precision oncology is to promote combination therapy to improve efficacy and reduce side effects of anti-cancer drugs based on their molecular mechanisms. In this study, we aimed to develop and validate new nanoformulations of docetaxel (DTX) and bortezomib (BTZ) for targeted combination therapy to treat human esophageal cancer. By leveraging our...

Progress and challenges in the use of latent HIV-1 reactivating agents

ScholarSearch for Tao Wu in:Nature Research journals • PubMed • Google ScholarSearch for Qiu-li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Fu-jun Liang in:Nature Research journals

Lapatinib-incorporated lipoprotein-like nanoparticles: preparation and a proposed breast cancer-targeting mechanism

HE designed the study; Li ZHANG performed the experiments and wrote the paper with the assistance of Shuang ZHANG, Shao-bo RUAN and Qian-yu ZHANG. References 1. Moreira C, Kaklamani V. Lapatinib ... Delivery, Ministry of Education, Shanghai 201203, ChinaShuang Zhang AuthorsSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Shuang Zhang in:Nature Research journals

Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation

the experiments, analyzed the data and drafted the manuscript; Zengchun MA, Qian-de LIANG, Xiang-lin TANG, Hong-ling TAN and Cheng-rong XIAO assisted with in the experiments; Bo-li ZHANG and Yue GAO

Comparative analysis of somatic copy-number alterations across different human cancer types reveals two distinct classes of breakpoint hotspots

Somatic copy-number alterations (SCNAs) play a crucial role in the development of human cancer. However, it is not well understood what evolutionary mechanisms contribute to the global patterns of SCNAs in cancer genomes. Taking advantage of data recently available through The Cancer Genome Atlas, we performed a systematic analysis on genome-wide SCNA breakpoint data for eight...

A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations

Vaccination against hepatitis B virus is an effective and routine practice that can prevent infection. However, 5–10% of healthy adults fail to produce protective levels of antibody against the hepatitis B vaccination. It has been reported that host genetic variants might affect the immune response to hepatitis B vaccination. Here, we reported a genome-wide association study in a...

Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells

Province of China (BK2010224) and US Public Health Service R01CA135038. Author contribution Jin-ming YANG designed research; Li ZHANG, Yi ZHANG, Xiao-yuan LIU performed research; Li ZHANG and Yi ZHANG ... analyzed data; Zheng-hong QIN contributed new analytical and tools; Li ZHANG and Yi ZHANG wrote the paper. npg 1 Serfass L, Van Herpen C , Saghatchian M. Molecular targets and cancer therapeutics . Eur J

Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn

ZHANG, and Jing ZHAO performed the research; Shang-li ZHANG analyzed the data; and Jing ZHAO, Di GE, and Ning MENG wrote the paper. References 1. Kalsner S. Coronary artery spasm. Multiple causes and ... AffiliationsInstitute of Developmental Biology, School of Life Science, Shandong University, Ji-nan 250100, ChinaDi Ge, Ning Meng, Le Su, Shang-li Zhang, Jun-ying Miao & Jing ZhaoKey Laboratory of Cardiovascular

Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits

Trisomy 21 (Down syndrome, DS) is the most common genetic cause of developmental cognitive deficits, and the so-called Down syndrome critical region (DSCR) has been proposed as a major determinant of this phenotype. The regions on human chromosome 21 (Hsa21) are syntenically conserved on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. DSCR is conserved between the Cbr1 and Fam3b...

Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in Btbd9 mutant mice

Restless legs syndrome (RLS), also known as Willis–Ekbom disease, is a sensory–motor neurological disorder with a circadian component. RLS is characterized by uncomfortable sensations in the extremities, generally at night or during sleep, which often leads to an uncontrollable urge to move them for relief. Recently, genomic studies identified single-nucleotide polymorphisms in...

Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1α, is another marker of lung tumor hypoxia

Aim:To explore the mechanism of differentiated embryo-chondrocyte expressed gene 1 (DEC1) in the lung adenocarcinoma A549 cell line and its relationship with hypoxia-inducible factor 1α (HIF-1α).Methods:DEC1 and HIF-1α protein levels were detected in lung adenocarcinoma tissues by immunohistochemistry. A549 cells were cultured at hypoxia. MTT assay was used to determine the...

Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

Fragile X syndrome (FXS), a common inherited form of intellectual disability with learning deficits, results from a loss of fragile X mental retardation protein (FMRP). Despite extensive research, treatment options for FXS remain limited. Since FMRP is known to play an important role in adult hippocampal neurogenesis and hippocampus-dependent learning and FMRP regulates the adult...

TRAP1 rescues PINK1 loss-of-function phenotypes

PTEN-induced kinase 1 (PINK1) is a serine/threonine kinase that is localized to mitochondria. It protects cells from oxidative stress by suppressing mitochondrial cytochrome c release, thereby preventing cell death. Mutations in Pink1 cause early-onset Parkinson's disease (PD). Consistently, mitochondrial function is impaired in Pink1-linked PD patients and model systems...

Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes

to efficiently screen similar compounds by LC-MS/MS for early identification of potential drugdrug interactions. Author contribution Li ZHANG, Min-ji WEI, and Hui-min QI designed research; Li ZHANG ... performed research; Min-ji WEI and Cai-yun ZHAO contributed new analytical tools and reagents; Li ZHANG, Min-ji WEI, and Hui-min QI analyzed data; Li ZHANG, Min-ji WEI, and Hui-min QI wrote the paper. 1

Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals

. Miao WANG, Li ZHANG, and Chang- somes by ultra-performance liquid chromatography with MS detection. hong WANG prepared the animal liver microsomes, Li YANG J Chromatogr B 2008; 870: 84–90. participated

Inhibition of iNOS protects endothelial-dependent vasodilation in aged rats

data; Jue TIAN, Zi YAN wrote the paper; Su-li ZHANG, Lin ZUO corrected this paper. 1 Lakatta EG , Levy D . Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I

Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients

Ru-tai HUI and Xiao-han FAN designed research; Xiao-han FAN, Yi-bo WANG, Hu WANG, Xiao-dong SONG, Jing-zhou CHENG, Hai-ying WU, and Xiang-liang ZHOU performed research; Kai SUN and Wei-li ZHANG ... Education, Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaYi-bo Wang, Hu Wang, Kai Sun, Wei-li Zhang, Xiao-dong Song

Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development

The question of whether DNA methylation contributes to the stabilization of gene expression patterns in differentiated mammalian tissues remains controversial. Using genome-wide methylation profiling, we screened 3757 gene promoters for changes in methylation during postnatal liver development to test the hypothesis that developmental changes in methylation and expression are...