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Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

of Wenzhou Medical University, Zhejiang, ChinaJun-Li Zhang, Xiao-Jun Zhuo, Jing Lin, Ling-Chun Luo, Wei-Yang Ying, Xiang Xie, Hua-Wei Zhang, Jing-Xiang Yang, Dan Li, Fang Gao Smith & Sheng-Wei ... JinAcademic Department of Anesthesia, Critical Care, Pain and Resuscitation, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UKFang Gao Smith AuthorsSearch for Jun-Li Zhang

Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis

Cathepsin B (CB) is involved in the turnover of proteins and has various roles in maintaining the normal metabolism of cells. In our recent study, CB is increased in the muscles of polymyositis/dermatomyositis (PM/DM). However, the role of CB in interstitial lung disease (ILD) has not been reported. ILD is a frequent complication of PM/DM, which is the leading cause of death in...

Inhibition of reactive oxygen species generation attenuates TLR4-mediated proinflammatory and proliferative phenotype of vascular smooth muscle cells

Outstanding Youth Science Foundation (No. CSTC2012JJJQ10003). Author information Author notesYan Pi & Li-li Zhang These authors contributed equally to this work. AffiliationsDepartment of Neurology ... , Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, ChinaYan Pi, Li-li Zhang, Bing-hu Li, Lu Guo, Xiao-jie Cao, Chang-yue Gao & Jing-cheng Li AuthorsSearch for Yan Pi

The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy

A growing body of evidence implicates inflammation in the development of diabetic nephropathy. We recently reported that diabetic endothelial nitric oxide synthase knockout (eNOS KO) mice develop advanced glomerular lesions resembling human diabetic nephropathy. Vascular endothelial growth factor (VEGF) is a major factor in diabetic nephropathy, and is known to be chemotactic for...

Alpha-1-Antitrypsin and a Broad Spectrum Metalloprotease Inhibitor, RS113456, Have Similar Acute Anti-Inflammatory Effects

There is increasing evidence that antiproteases are able to affect the inflammatory response. To further examine this question, we administered human α-1-antitrypsin (α1AT) or a synthetic metalloprotease inhibitor (RS113456) to C57 mice followed by a single intratracheal dose of quartz, a dust that evokes a marked, lasting, polymorphonuclear leukocyte (PMN) infiltrate. At 2 hours...