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Comparative transcriptomic profiling of peripheral efferent and afferent nerve fibres at different developmental stages in mice

Peripheral nerve injury impairs motor and sensory function in humans, and its functional recovery largely depends on the axonal outgrowth required for the accurate reinnervation of appropriate targets. To better understand how motor and sensory nerve fibres select their terminal pathways, an unbiased cDNA microarray analysis was conducted to examine differential gene expression...

MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway

Research journals • PubMed • Google Scholar Search for Fuqian He in:Nature Research journals • PubMed • Google Scholar Search for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for ... Liu analyzed the data and wrote the paper; Fuqian He & Li Zhang contributed to the gene transfection; Kun Yang, Huan Yu & Jinqiu Zhou helped to isolate the colon myenteric plexus and immunofluorescence

Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD

Peiyong Zheng Li Zhang Guang Ji OPEN To enhance our understanding of molecular mechanisms and mine novel biomarkers of non-alcoholic fatty liver disease (NAFLD), RNA sequencing was performed to gain

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use. In the current study, a morphine-murine model was used to investigate the role of the gut microbiome and metabolome as a potential mechanism contributing to the...

Design of Phase Gradient Coding Metasurfaces for Broadband Wave Modulating

Wave modulating is one of the most interesting applications of metasurfaces. It requires an effective method to design metasurfaces with arbitrary space-variant phase. In this paper, we proposed an optimized design method for arbitrarily modulating wave based on the Genetic Algorithm, which is efficient to optimize designated radiation patterns according to application...

Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity

We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and...

Comprehensive Review of Genetic Association Studies and Meta-Analysis on polymorphisms in microRNAs and Urological Neoplasms Risk

Li Zhang & Chaozhao LiangInstitute of Urology, Anhui Medical University, Hefei, 230022, ChinaLigang Zhang, Meng Zhang, Yangyang Wang, Jun Zhou, Zongyao Hao, Li Zhang & Chaozhao LiangGraduate School of ... Research journals • PubMed • Google Scholar Search for Zongyao Hao in:Nature Research journals • PubMed • Google Scholar Search for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search

Clinical Implications of the Autophagy Core Gene Variations in Advanced Lung Adenocarcinoma Treated with Gefitinib

EGFR-TKIs show dramatic treatment benefits for advanced lung adenocarcinoma patients with activating EGFR mutations. Considering the essential role of autophagy in EGFR-TKIs treatments, we hypothesized that genetic variants in autophagy core genes might contribute to outcomes of advanced lung adenocarcinoma treated with gefitinib. We systematically examined 27 potentially...

Combining Low-dimensional Wavelet Features and Support Vector Machine for Arrhythmia Beat Classification

conducted the experiments. Qin Qin and Chengyu Liu drafted the paper. Li Zhang refined the manuscript. Jianqing Li provided the experiment equipment and project support. All the authors contributed to the

Health-related quality of life among adults with and without hypertension: A population-based survey using EQ-5D in Shandong, China

Disease Control and Prevention , Jinan , China 2 Collaborative Innovation Center of Social Risks Governance in Health; School of Public Health, Shandong University , Jinan , China. Li Zhang and Xiaolei

Maximum Power Point Tracking for Cascaded PV-Converter Modules Using Two-Stage Particle Swarm Optimization

The paper presents a novel two-stage particle swarm optimization (PSO) for the maximum power point tracking (MPPT) control of a PV system consisting of cascaded PV-converter modules, under partial shading conditions (PSCs). In this scheme, the grouping method of the shuffled frog leaping algorithm (SFLA) is incorporated with the basic PSO algorithm, ensuring fast and accurate...

Proper time regularization and the QCD chiral phase transition

We study the QCD chiral phase transition at finite temperature and finite quark chemical potential within the two flavor Nambu–Jona-Lasinio (NJL) model, where a generalization of the proper-time regularization scheme is motivated and implemented. We find that in the chiral limit the whole transition line in the phase diagram is of second order, whereas for finite quark masses a...

Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment

, Chen Chen, Li Zhang & Yubao LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610064 ... Chen in:Nature Research journals • PubMed • Google Scholar Search for Songsong Zhu in:Nature Research journals • PubMed • Google Scholar Search for Li Zhang in:Nature Research journals • PubMed

Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan

The safe and effective delivery of therapeutic genes into target cell interiors is of great importance in gene therapy. Chitosan has been extensively studied as a gene delivery carrier due to its good biocompatibility and biodegradability. Understanding the atomic interaction mechanism between chitosan and DNA is important in the design and application of chitosan-based drug and...

Application of cardiovascular virtual endoscopy: a pilot study on roaming path planning for diagnosis of congenital heart diseases in children

• PubMed • Google Scholar Search for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for Hui-Ming Li in:Nature Research journals • PubMed • Google Scholar Search for Ming Ding ... , and interpretation of data for the work, and drafting the work; AND (2) Li Zhang Ju Mei, Fang-Bao Ding, Hui-Ming Li, Ming Ding, Xin Yang, Xiao-Ming Li, Kun Sun, revising it critically for important

Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005–2013) in eastern China

Feng Ji Aiqiang Xu Li Zhang OPEN Limited information is available about the temporal trend in the prevalence and evolution of hepatitis B virus (HBV) S-gene mutations in the post-immunization era in

Vitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study

The metabolic health effects of vitamin A and E nutritional status in early life are largely unknown. We assessed whether vitamin A and vitamin E nutritional status may affect circulating leptin, adiponectin, insulin-like growth factor (IGF)-I and IGF-II levels in early life in humans. In a singleton birth cohort (n = 248), vitamin A and E nutritional status in fetuses/newborns...

High-fat diet and chronic stress aggravate adrenal function abnormality induced by prenatal caffeine exposure in male offspring rats

Lian Liu Chunyan Zhu Youyin Lei Li Zhang Cai Si Hui Wang OPEN Published: xx xx xxxx We previously demonstrated thatprenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted

Chronic Intermittent Hypobaric Hypoxia Improves Cardiac Function through Inhibition of Endoplasmic Reticulum Stress

We investigated the role of endoplasmic reticulum stress (ERS) in chronic intermittent hypobaric hypoxia (CIHH)-induced cardiac protection. Adult male Sprague-Dawley rats were exposed to CIHH treatment simulating 5000 m altitude for 28 days, 6 hours per day. The heart was isolated and perfused with Langendorff apparatus and subjected to 30-min ischemia followed by 60-min...

One-pot synthesis of class II lanthipeptide bovicin HJ50 via an engineered lanthipeptide synthetase

Lanthipeptides are a large class of bacteria-produced, ribosomally-synthesized and post-translationally modified peptides. They are recognized as peptide antibiotics because most of them exhibit potent antimicrobial activities against Gram-positive bacteria especially those that are phylogenetically related to producers. Maturation of class II lanthipeptide like bovicin HJ50...