Advanced search    

Search: authors:"Li Zhang"

1,068 papers found. Showing first 1,000 results.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway

Gastric cancer is one of the deadliest malignant tumours, with a high incidence in China, and is regulated by aberrantly overexpressed oncogenes. However, existing therapies are insufficient to meet patients’ needs; thus, the identification of additional therapeutic targets and exploration of the underlying mechanism are urgently needed. GPAA1 is the subunit of the GPI...

Identification of cucumber circular RNAs responsive to salt stress

Circular RNAs (circRNAs) are 3′-5′ head-to-tail covalently closed non-coding RNA that have been proved to play essential roles in many cellular and developmental processes. However, no information relate to cucumber circRNAs is available currently, especially under salt stress condition. In this study, we sequenced circRNAs in cucumber and a total of 2787 were identified, with...

A Preliminary Study of Uric Metabolomic Alteration for Postpartum Depression Based on Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry

Academic Editor: Hubertus Himmerich Copyright © 2019 Li Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution

Role of physical performance measures for identifying functional disability among Chinese older adults: Data from the China Health and Retirement Longitudinal Study

. Relevant dataset underlying the findings described in manuscript. (RAR) S2 File. The codebook of the dataset. (PDF) Acknowledgments Author Contributions Conceptualization: Li Zhang, Linwen Guo. Data

Improved simulation of carbon and water fluxes by assimilating multi-layer soil temperature and moisture into process-based biogeochemical model

BackgroundSoil temperature and moisture are sensitive indicators in soil organic matter decomposition because they control global carbon and water cycles and their potential feedback to climatic variations. Although the Biome-Biogeochemical Cycles (Biome-BGC) model is broadly applied in simulating forest carbon and water fluxes, its single-layer soil module cannot represent...

Changes in ankle joint alignment after proximal fibular osteotomy

. Author Contributions Conceptualization: Yingze Zhang. Data curation: Li Zhang, Weichong Dong. Formal analysis: Li Zhang, Wei Chen, Weichong Dong. Investigation: Wei Chen. Methodology: Jialiang Guo, Wei ... Chen. Project administration: Li Zhang, Di Qin, Wei Chen. Resources: Weichong Dong. 10 / 11 Software: Jialiang Guo, Wei Chen. Supervision: Di Qin, Zhiyong Hou, Yingze Zhang. Validation: Zhiyong Hou

Topological evolution of coexpression networks by new gene integration maintains the hierarchical and modular structures in human ancestors

We analyze the global structure and evolution of human gene coexpression networks driven by new gene integration. When the Pearson correlation coefficient is greater than or equal to 0.5, we find that the coexpression network consists of 334 small components and one “giant” connected subnet comprising of 6317 interacting genes. This network shows the properties of power-law...

Association between gaseous pollutants and emergency ambulance dispatches for asthma in Chengdu, China: a time-stratified case-crossover study

ObjectivesThe association between concentrations of sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), ozone (O3), and emergency ambulance dispatches (EADs) for asthma was explored in the central Sichuan Basin of southwestern China for the first time.MethodsEADs for asthma were collected from the Chengdu First-Aid Command Center. Pollutant concentrations were...

Choice revision

Journal of Logic, Language and Information pp 1–23 | Cite as Choice revision AuthorsAuthors and affiliations Li Zhang Open Access Article First Online: 14 March 2019 85 Downloads

First-line afatinib vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients who continued treatment beyond progression

PurposeIn the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer. We report post hoc analyses of tolerability-guided dose adjustment for afatinib and summarize the clinical...

H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

of Physiology and Neurobiology, Institute for Systems Genomics, University of Connecticut, Storrs, CT, 06269, USAJianguo Wu AuthorsSearch for Li Zhang in:Nature Research journals • PubMed • Google

Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes

PurposePodocytes are terminally differentiated cells lining the Bowman’s capsule. Podocytes are critical for the proper glomerular filtration barrier function. At the same time, autophagy is crucial for maintaining podocyte homeostasis and insufficient autophagy could cause podocyte loss and proteinuria that is commonly observed in diabetic nephropathy (DN).MethodsIn this study...

COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals—symptom relief accompanied by worrisome volume reductions

Investigation of auditory verbal hallucinations (AVHs) in schizophrenics is complicated by psychiatric symptoms. Investigating healthy individuals with AVHs (H-AVHs) can obviate such confounding factors. The objective of this study was to explore the effects of antipsychotic treatment on AVHs and gray matter volumes (GMVs) in H-AVH subjects and whether such are effects are...

Expression of cancer–testis antigens in esophageal cancer and their progress in immunotherapy

PurposeEsophageal cancer is a common disease in China with low survival rate due to no obvious early symptoms and lack of effective screening strategies. Traditional treatments usually do not produce desirable results in patients with advanced esophageal cancer, so immunotherapy which relies on tumor-related antigens is needed to combat low survival rates effectively. Cancer...

Neural Personalized Ranking via Poisson Factor Model for Item Recommendation

Recommender systems have become indispensable for online services since they alleviate the information overload problem for users. Some work has been proposed to support the personalized recommendation by utilizing collaborative filtering to learn the latent user and item representations from implicit interactions between users and items. However, most of existing methods...

New versions of the Hestenes-Stiefel nonlinear conjugate gradient method based on the secant condition for optimization

Based on the secant condition often satisfied by quasi-Newton methods, two new versions of the Hestenes-Stiefel (HS) nonlinear conjugate gradient method are proposed, which are descent methods even with inexact line searches. The search directions of the proposed methods have the form dk = - θkgk + βkHSdk-1, or dk = -gk + βkHSdk-1+ θkyk-1. When exact line searches are used, the...

Immune-checkpoint inhibitor plus chemotherapy versus conventional chemotherapy for first-line treatment in advanced non-small cell lung carcinoma: a systematic review and meta-analysis

interests Li Zhang has received research support from AstraZeneca, Eli Lilly and company, and Roche. No other disclosures were reported. Publisher’s Note Springer Nature remains neutral with regard to

Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population

The present study evaluated the predictive ability of five known “best” obesity and lipid-related parameters, including body mass index (BMI), waist-to-height ratio (WHtR), triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C), lipid accumulation product (LAP) and visceral adiposity index (VAI), in identifying metabolic syndrome (MetS) in Chinese elderly population. A...

A Novel Integrative Processing Technology for the Preparation of Rehmanniae Radix Slices

Correspondence should be addressed to Li Zhang; nc.ude.mcujn@ilgnahz Received 27 July 2018; Revised 19 November 2018; Accepted 10 December 2018; Published 20 December 2018 Academic Editor: Srinivas Nammi

Size-dependent cytotoxicity of silver nanoparticles to Azotobacter vinelandii: Growth inhibition, cell injury, oxidative stress and internalization

Zhang, Lingli Wu, Kunhui Shu. Methodology: Li Zhang. Resources: Youbin Si. Supervision: Youbin Si. 14 / 18 Writing – original draft: Li Zhang. Writing – review & editing: Li Zhang, Youbin Si. 15 / 18 ... be internalizated in cells. Acknowledgments This work was supported by the National Natural Science Foundation of China [grant numbers 41430752, 41471405]. Author Contributions Investigation: Li