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Suppression of angiotensin II stimulated responses in aortic vascular smooth muscle cells of experimental cirrhotic rats

Functional responses to angiotensin II (AT-II) were determined in aortic vascular smooth muscle cells (VSMCs) from experimental cirrhotic rats. Our data showed that AT-II-stimulated extracellular acidification rate (ECAR), which was measured by Cytosensor microphysiometry, was significantly reduced in the aortic VSMCs from the cirrhotic rats as compared to those from the control...

Alpha-1-Antitrypsin and a Broad Spectrum Metalloprotease Inhibitor, RS113456, Have Similar Acute Anti-Inflammatory Effects

There is increasing evidence that antiproteases are able to affect the inflammatory response. To further examine this question, we administered human α-1-antitrypsin (α1AT) or a synthetic metalloprotease inhibitor (RS113456) to C57 mice followed by a single intratracheal dose of quartz, a dust that evokes a marked, lasting, polymorphonuclear leukocyte (PMN) infiltrate. At 2 hours...

Cloning and molecular characterization of a novel gene strongly induced by the adenovirus E1A gene in rat thyroid cells

Expression of the adenovirus E1A gene in the rat thyroid differentiated cell line PC Cl 3 induces thyrotropin-independent cell growth and impairs differentiation. However, the malignant phenotype is achieved only when the PC E1A cells are infected with other murine retroviruses carrying the v-abl, v-raf or polyoma middle-T genes. To determine through which genes E1A affects...

The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy

A growing body of evidence implicates inflammation in the development of diabetic nephropathy. We recently reported that diabetic endothelial nitric oxide synthase knockout (eNOS KO) mice develop advanced glomerular lesions resembling human diabetic nephropathy. Vascular endothelial growth factor (VEGF) is a major factor in diabetic nephropathy, and is known to be chemotactic for...

Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients

Ru-tai HUI and Xiao-han FAN designed research; Xiao-han FAN, Yi-bo WANG, Hu WANG, Xiao-dong SONG, Jing-zhou CHENG, Hai-ying WU, and Xiang-liang ZHOU performed research; Kai SUN and Wei-li ZHANG ... Education, Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaYi-bo Wang, Hu Wang, Kai Sun, Wei-li Zhang, Xiao-dong Song

Prognostic and biological significance of survivin expression in patients with diffuse large B-cell lymphoma treated with rituximab-CHOP therapy

17 Xin Cao 9 17 Ganiraju C Manyam 10 17 Xiaoxiao Wang 9 17 Alexandar Tzankov 11 17 Yi Xia 9 17 Xin Li 9 17 Carlo Visco 12 17 Ruifang Sun 9 17 Li Zhang 10 17 Santiago Montes-Moreno 13 17 Karen Dybkaer

Inhibition of iNOS protects endothelial-dependent vasodilation in aged rats

data; Jue TIAN, Zi YAN wrote the paper; Su-li ZHANG, Lin ZUO corrected this paper. 1 Lakatta EG , Levy D . Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I

Evidence for a critical role of gene occlusion in cell fate restriction

The progressive restriction of cell fate during lineage differentiation is a poorly understood phenomenon despite its ubiquity in multicellular organisms. We recently used a cell fusion assay to define a mode of epigenetic silencing that we termed “occlusion”, wherein affected genes are silenced by cis-acting chromatin mechanisms irrespective of whether trans-acting...

A model of molecular interactions on short oligonucleotide microarrays

Cerveny Dana F Chace Ron L DeBlanc R Patrick Gearing Tim D Bovee Clay B Siegall Joseph A Francisco Alan F Wahl Damon L Meyer Peter D Senter Nat. Biotechnol. Li Zhang Michael F Miles Kenneth D Aldape Nat

The Mechanism of Chemokine Receptor 9 Internalization Triggered by Interleukin 2 and Interleukin 4

In previous study, we found that the chemokine receptor 9 (CCR9) was highly expressed on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia (T-ALL) and mediated leukemia cell infiltration and metastasis. Combined use of interleukin 2 (IL-2) and IL-4 promoted the internalization of CCR9 and therefore attenuated leukemia cell infiltration and metastasis. In...

The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

The tyrosine phosphorylation barcode encoded in C-terminus of HER2 and its ubiquitination regulate diverse HER2 functions. PTPN18 was reported as a HER2 phosphatase; however, the exact mechanism by which it defines HER2 signaling is not fully understood. Here, we demonstrate that PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and...

Sequential Fluorescent Labeling Observation of Maxillary Sinus Augmentation by a Tissue‐engineered Bone Complex in Canine Model

AimTo evaluate the effects of maxillary sinus floor elevation by a tissue‐engineered bone complex of β‐tricalcium phosphate (β‐TCP) and autologous osteoblasts in dogs.MethodologyAutologous osteoblasts from adult Beagle dogs were cultured in vitro. They were further combined with β‐TCP to construct the tissue‐engineered bone complex. 12 cases of maxillary sinus floor elevation...

A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

, California 91320, USAMonica Florio, Marina Stolina, Xiaodong Li, Franklin J. Asuncion, Chaoyang Li, Banghua Sun, Hong Lin Tan, Li Zhang, Chun-Ya Han, Mario Grisanti, William G. Richards, Hua Zhu Ke & Michael S ... • PubMed • Google ScholarSearch for Hong Lin Tan in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Chun-Ya Han in:Nature

Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals

. Miao WANG, Li ZHANG, and Chang- somes by ultra-performance liquid chromatography with MS detection. hong WANG prepared the animal liver microsomes, Li YANG J Chromatogr B 2008; 870: 84–90. participated

Cobalt phosphate-modified barium-doped tantalum nitride nanorod photoanode with 1.5% solar energy conversion efficiency

System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113 8656, JapanYanbo Li, Li Zhang, Jun Kubota & Kazunari DomenDepartamento de química Inorgánica, Facultad de Químicas ... Cha, Lan Zhao & Kazuhiro Takanabe AuthorsSearch for Yanbo Li in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhang in:Nature Research journals • PubMed • Google ScholarSearch for

Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes

to efficiently screen similar compounds by LC-MS/MS for early identification of potential drugdrug interactions. Author contribution Li ZHANG, Min-ji WEI, and Hui-min QI designed research; Li ZHANG ... performed research; Min-ji WEI and Cai-yun ZHAO contributed new analytical tools and reagents; Li ZHANG, Min-ji WEI, and Hui-min QI analyzed data; Li ZHANG, Min-ji WEI, and Hui-min QI wrote the paper. 1

Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases

Heme (iron protoporphyrin IX) is an essential molecule for numerous living organisms. Not only does it serve as a prosthetic group in enzymes, it also acts as a signaling molecule that controls diverse molecular and cellular processes ranging from signal transduction to protein complex assembly. Deficient heme synthesis or function impacts the hematopoietic, hepatic and nervous...

3,3′-Diiodothyronine sulfate cross-reactive material (compound W) in human newborns

Background:Thyrosulfoconjugation appears to facilitate fetal-to-maternal transfer of 3,3′-diiodothyronine-sulfate (T2S). Elevated maternal levels of T2S cross-reactive material (compound W) are found in humans, with higher levels found in venous cord blood than in arterial samples. These findings are consistent with the postulate that the placenta plays an essential role in...

Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1α, is another marker of lung tumor hypoxia

Aim:To explore the mechanism of differentiated embryo-chondrocyte expressed gene 1 (DEC1) in the lung adenocarcinoma A549 cell line and its relationship with hypoxia-inducible factor 1α (HIF-1α).Methods:DEC1 and HIF-1α protein levels were detected in lung adenocarcinoma tissues by immunohistochemistry. A549 cells were cultured at hypoxia. MTT assay was used to determine the...