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Tubeimoside I induces accumulation of impaired autophagolysosome against cervical cancer cells by both initiating autophagy and inhibiting lysosomal function

in:Nature Research journals • PubMed • Google Scholar Search for Shuyue Fu in:Nature Research journals • PubMed • Google Scholar Search for Li Zhou in:Nature Research journals • PubMed • Google Scholar

Imaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers

The purpose of this retrospective study is to evaluate the cumulative imaging doses, the associated cancer risk and the cost related to the various radiological imaging procedures in image-guided radiotherapy of cancers. Correlations between patients’ size and Monte Carlo simulated organ doses were established and validated for various imaging procedures, and then used for...

Generation of all-male-like sterile zebrafish by eliminating primordial germ cells at early development

Production of all-male and sterile fish may not only substantially improve yield but also be crucial for the application of genome modified species in aquaculture. Previously, it was reported that the fish lacking primordial germ cells (PGCs) becomes infertile, and nitroreductase, an enzyme converting non-toxic metronidazole (MTZ) into toxic metabolites, induces targeted toxicity...

Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

• Google Scholar Search for Jiong Deng in:Nature Research journals • PubMed • Google Scholar Search for Li Zhou in:Nature Research journals • PubMed • Google Scholar Search for Yingli Wu in:Nature Research ... journals • PubMed • Google Scholar Conflict of interest The authors declare that they have no conflict of interest. Corresponding authors Correspondence to Jiong Deng or Li Zhou or Yingli Wu

The Us2 Gene Product of Herpes Simplex Virus 2 modulates NF-κB activation by targeting TAK1

Science Foundation of China (81301428 to Li Zhou, 31500149 to Shi Liu and 81602448 to Jingfeng Tang); the Fundamental Research Funds for the Central Universities (2042015kf0188 to Li Zhou and 2042015kf0029 ... to Shi Liu); the open project of the State Key Laboratory of Biocontrol (SKLBC16KF01 to Li Zhou), the Natural Science Foundation of Hubei Province (2016CFB105 to Yi Zhang); the Research Fund for the

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation

(2016A030313286). Author contribution Liao SUN and Jie XU conceived and designed the experiments; Bing ZHOU and Dan-li ZHOU performed the experiments; Bing ZHOU, Xiao-hong WEI, and Rong-yu ZHONG analyzed the data

Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology

notes Changhe Wang, Xinjiang Kang and Li Zhou contributed equally to this work. AffiliationsState Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine ... , Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, ChinaChanghe Wang, Xinjiang Kang, Li Zhou

Identification of 11(13)-dehydroivaxillin as a potent therapeutic agent against non-Hodgkin's lymphoma

Yin Tong Li Zhou Hu Lei Hanzhang Xu Weidong Zhang Wei Liu Yingli Wu Despite great advancements in the treatment of non-Hodgkin lymphoma (NHL), sensitivity of different subtypes to therapy varies

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

Fat distribution is strongly associated with insulin resistance, a risk factor for type 2 diabetes and cardiovascular diseases. However, associations of different adipose tissue depots or/and obesity indices with insulin resistance have not been systematically evaluated. In this study we examined associations of different adipose tissue depots/obesity indices with insulin...

Tuning of Exchange Coupling and Switchable Magnetization Dynamics by Displacing the Bridging Ligands Observed in Two Dimeric Manganese(III) Compounds

for Li-Zhou Wu in:Nature Research journals • PubMed • Google ScholarSearch for Fei-Fei Li in:Nature Research journals • PubMed • Google ScholarSearch for Wei-Ming Song in:Nature Research journals

Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer

performed the experiments and wrote the paper; Li Zhou and Shuwen Yang collected the samples and clinicopathogical data of patients; Ben Ma and Chuanpeng Dong were responsible for all bioinformatics and

Origin of unusual HREE-Mo-rich carbonatites in the Qinling orogen, China

Carbonatites, usually occurring within intra-continental rift-related settings, have strong light rare earth element (LREE) enrichment; they rarely contain economic heavy REE (HREE). Here, we report the identification of Late Triassic HREE-Mo-rich carbonatites in the northernmost Qinling orogen. The rocks contain abundant primary HREE minerals and molybdenite. Calcite-hosted...

The MiR-135b–BMAL1–YY1 loop disturbs pancreatic clockwork to promote tumourigenesis and chemoresistance

Jiang, Yangyang Hu, Kai Li, Sisi Li, Li Zhou, Li Huang, Zhanjun Lu, Yun Feng, Lijuan Yang & Rong WanShanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong ... University School of Medicine, Shanghai, ChinaWeiliang Jiang, Yangyang Hu, Kai Li, Sisi Li, Li Zhou, Li Huang, Zhanjun Lu, Yun Feng, Lijuan Yang & Rong WanDepartment of General Surgery, Shanghai General

Enhanced thermal conductivity of epoxy composites filled with silicon carbide nanowires

• Google Scholar Search for Li Zhou in:Nature Research journals • PubMed • Google Scholar Search for Yuanli Liu in:Nature Research journals • PubMed • Google Scholar Search for Wen Dai in:Nature Research

Analysis of effects of a new environmental pollutant, bisphenol A, on antioxidant systems in soybean roots at different growth stages

University, Wuxi 214122, ChinaJiazhi Zhang, Xingyi Li, Li Zhou, Lihong Wang & Qing ZhouJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials ... University of Science and Technology, Suzhou 215009, ChinaJiazhi Zhang, Xingyi Li, Li Zhou, Lihong Wang & Qing Zhou AuthorsSearch for Jiazhi Zhang in:Nature Research journals • PubMed • Google ScholarSearch

Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats

 & Guo-Rong Yuan AuthorsSearch for Fan Yang in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Dong Wang in:Nature

Plasmon-Modulated Excitation-Dependent Fluorescence from Activated CTAB Molecules Strongly Coupled to Gold Nanoparticles

Excitation-dependent fluorophores (EDFs) have been attracted increasing attention owing to their high tunability of emissions and prospective applications ranging from multicolor patterning to bio-imaging. Here, we report tunable fluorescence with quenching dip induced by strong coupling of exciton and plasmon in the hybrid nanostructure of CTAB* EDFs and gold nanoparticles...

Crystallization characteristics in supercooled liquid zinc during isothermal relaxation: A molecular dynamics simulation study

The crystallization characteristics in supercooled liquid Zn during isothermal relaxation were investigated using molecular dynamics simulations by adopting the cluster-type index method (CTIM) and the tracing method. Results showed that the crystallization process undergo three different stages. The size of the critical nucleus was found to be approximately 90–150 atoms in this...

Construction of a subunit-fusion nitrile hydratase and discovery of an innovative metal ion transfer pattern

Metallochaperones are metal-binding proteins designed to deliver the appropriate metal to a target protein. The metal is usually transferred between different proteins. In this study, we discovered that metal was transferred between the same subunit of a mutant nitrile hydratase (NHase). Various “activator proteins” mediate the trafficking of metal ions into NHases. We...

A Modified Thyroid Imaging Reporting and Data System (mTI-RADS) For Thyroid Nodules in Coexisting Hashimoto’s Thyroiditis

Xian-Li Zhou Hui-Xiong Xu OPEN To develop a conventional ultrasound (US) modified Thyroid Imaging Reporting and Data System (mTI-RADS) to stratify the malignancy risk of thyroid nodule in coexisting