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Isolation and characterization of Bacillus sp. GFP-2, a novel Bacillus strain with antimicrobial activities, from Whitespotted bamboo shark intestine

The abuse of antibiotics and following rapidly increasing of antibiotic-resistant pathogens is the serious threat to our society. Natural products from microorganism are regarded as the important substitution antimicrobial agents of antibiotics. We isolated a new strain, Bacillus sp. GFP-2, from the Chiloscyllium plagiosum (Whitespotted bamboo shark) intestine, which showed great...

Application of BOLD-MRI in the classification of renal function in chronic kidney disease

PurposeThe purpose of the study was to explore the application of blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-MRI) in classification of chronic kidney disease (CKD).MethodsTwenty-nine cases with CKD and 27 healthy volunteers underwent renal BOLD-MRI. Cases of CKD were divided into two groups according to the estimated glomerular filtration rate...

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation

(2016A030313286). Author contribution Liao SUN and Jie XU conceived and designed the experiments; Bing ZHOU and Dan-li ZHOU performed the experiments; Bing ZHOU, Xiao-hong WEI, and Rong-yu ZHONG analyzed the data

Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway

experiments; Jun NI and De-cui SHAO analyzed the data; Nai-jun MIAO and Jin-lan XU contributed the reagents and materials; Ya-li KONG, Li ZHOU, and Hong XUE wrote the manuscript. Ya-li KONG, Xiao-xia WANG and ... AffiliationsDepartment of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaYa-li Kong, Yang Shen, Jun Ni, De-cui Shao, Nai-jun Miao, Jin-lan Xu, Li Zhou, Hong Xue, Wei

P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells

performed experiments; De-cui SHAO and Jia LIU analyzed the data; Ya-li KONG and Lan-jun FU contributed reagents and materials; Jun NI, Li ZHOU, and Hong XUE wrote the manuscript. npg npg npg 1165 1 Eddy AA

Mesenchymal stem cells transplantation suppresses inflammatory responses in global cerebral ischemia: contribution of TNF-α-induced protein 6

. Qing-ming LIN, Shen ZHAO, and Li-li ZHOU performed the research. Qing-ming LIN, Shen ZHAO, and Zitong HUANG analyzed the data and wrote the paper. npg 1 Jones AE . Hypothermia after cardiac arrest: we

Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells

Aim:Both adrenomedullin (ADM) and adrenotensin (ADT) are derived from the same propeptide precursor, and both act as circulating hormones and local paracrine mediators with multiple biological activities. Compared with ADM, little is known about how ADT achieves its functions. In the present study, we investigated the effect of ADT on cell proliferation and transforming growth...

Adenosine 5′-triphosphate stimulates the increase of TGF-β1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2

designed research; proliferation and apoptotic cell death via P2Y and P2X receptors, Lin-ping QU, Hong XUE, Ping YUAN, Li ZHOU performed respectively, in rat glomerular mesangial cells. Kidney Int 2000; 57 ... : research; Lin-ping QU, Li ZHOU analyzed data; Lin-ping QU, 949?58. 21 Kennedy C. The discovery and development of P2 receptor subtypes. Tai YAO, Yu HUANG, and Li-min LU wrote the paper. J Auton Nerv Syst

Erratum to: Mechanical ion gate for electrospray-ionization ion-mobility spectrometry

the design of the ion mobility spectrometer. The correct sequence of authors of this contribution is: Li Zhou , David C. Collins, Edgar D. Lee, Alan L. Rockwood and Milton L. Lee 2 ) Department of

The effects of forest type on soil microbial activity in Changbai Mountain, Northeast China

Key message Forty years after clear-cutting mixed old-growth forest (broadleaf/Korean pine) in the Changbai Mountain area (Northeast China), a mixed forest with natural broadleaf regeneration and larch plantation displayed larger microbial biomass and activity in the soil than either a naturally regenerated birch forest or a monospecific spruce plantation. Context Clear-cutting...

Verrucosispora rhizosphaerae sp. nov., isolated from mangrove rhizosphere soil

An actinomycete strain, 2603PH03T, was isolated from a mangrove rhizosphere soil sample collected in Wenchang, China. Phylogenetic analysis of the 16S rRNA gene sequence of strain 2603PH03T indicated high similarity to Verrucosispora gifthornensis DSM 44337T (99.4%), Verrucosispora andamanensis (99.4%), Verrucosispora fiedleri MG-37T (99.4%) and Verrucosispora maris AB18-032T (99...

Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

Background Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed? One model supposes that splicing is inherently noisy and spurious transcripts are common. The evolution of a premature termination codon in a...

Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion

Background Elevated Plexin-B1 expression has been found in diverse human cancers and in non-neoplastic tissues, and it mediates diverse biological and pathological activities. However, whether or not Plexin-B1 expression is involved in human ovarian tumors remains unclear. In the present study, Plexin-B1 expression was explored in benign and malignant human ovarian tumor tissues...

Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Donghong Zhang 0 Qingying Zhang Li Zhou Leijun Huo 0 Yi Zhang Zhongying Shen Yi Zhu 0 0 Cardiovascular Research Center, Shantou University Medical College , 22 Xinling Road, Shantou, Guangdong

Comparative transcriptome profiling of a rice line carrying Xa39 and its parents triggered by Xanthomonas oryzae pv. oryzae provides novel insights into the broad-spectrum hypersensitive response

Background Bacterial blight, caused by Xanthomonas oryzae pv. oryzae (Xoo), is a devastating rice disease worldwide. Xa39 is a resistance (R) gene with a broad-spectrum hypersensitive response (BSHR) to Xoo. Nevertheless, the molecular mechanisms of resistance mediated by Xa39 remain unclear. In this study, the transcriptome profiling of a rice line carrying Xa39 and its parents...

Complete depletion of primordial germ cells in an All-female fish leads to Sex-biased gene expression alteration and sterile All-male occurrence

Li Yang Wang Xi-Yin Li Jian-Xiang Zhong Xiao-Juan Zhang Jun Zhang Li Zhou Jian-Fang Gui 0 Equal contributors State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology

Genome-wide association study on serum alkaline phosphatase levels in a Chinese population

Background Serum alkaline phosphatase (ALP) is a complex phenotype influenced by both genetic and environmental factors. Recent Genome-Wide Association Studies (GWAS) have identified several loci affecting ALP levels; however, such studies in Chinese populations are limited. We performed a GWAS analyzing the association between 658,288 autosomal SNPs and serum ALP in 1,461...

A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration

Background HIV-associated dementia (HAD) is the most common dementia type in young adults less than 40 years of age. Although the neurotoxins, oxidative/metabolic stress and impaired activity of neurotrophic factors are believed to be underlying reasons for the development of HAD, the genomic basis, which ultimately defines the virus-host interaction and leads to neurologic...

Genome-wide gene responses in a transgenic rice line carrying the maize resistance gene Rxo1 to the rice bacterial streak pathogen, Xanthomonas oryzae pv. oryzicola

Background Non-host resistance in rice to its bacterial pathogen, Xanthomonas oryzae pv. oryzicola (Xoc), mediated by a maize NBS-LRR type R gene, Rxo1 shows a typical hypersensitive reaction (HR) phenotype, but the molecular mechanism(s) underlying this type of non-host resistance remain largely unknown. Results A microarray experiment was performed to reveal the molecular...

Surgeons’ knowledge regarding the diagnosis and management of pancreatic cancer in China: a cross-sectional study

Pancreatic cancer is rare but highly malignant. Studies have shown that surgeons’ knowledge closely links to the correct diagnosis and treatment outcomes of pancreatic cancer. The purpose of this study was to survey current surgeons’ knowledge regarding pancreatic cancer. A cross-sectional study was conducted among 705 surgeons who attended the 2011 China Surgical Week’s meeting...