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Targeting GPER1 to suppress autophagy as a male-specific therapeutic strategy for iron-induced striatal injury

The functional outcome of intracerebral hemorrhage (ICH) in young male patients are poor than in premenopausal women. After ICH, ferrous iron accumulation causes a higher level of oxidative injury associated with autophagic cell death in striatum of male mice than in females. In rodent model of ferrous citrate (FC)-infusion that simulates iron accumulation after ICH, female...

A Revised Model of the Neutral DEA Model and Its Extension

The neutral data envelopment analysis (DEA) model is an alternative way to determine the weights in DEA cross-efficiency evaluation, while avoiding the difficulty in making a choice between the aggressive and benevolent formulations. However, the weights determined by the neutral model merely make the efficiency of part output bigger than other sets of weights. The neutral model...

Protecting User Privacy in a Multi-Path Information-Centric Network Using Multiple Random-Caches

their valuable comments and suggestions which certainly improve the quality of this paper. Li-Fang Wang is currently a professor in the School of Computer Science and Technology, Northwestern

Water–use efficiency of dryland wheat in response to mulching and tillage practices on the Loess Plateau

Shangguan AuthorsSearch for Li-fang Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhou-ping Shangguan in:Nature Research journals • PubMed • Google Scholar Contributions L.W. and Z.S

Yield Responses of Wheat to Mulching Practices in Dryland Farming on the Loess Plateau

Improving farming practices of soil and water conservation has profound effects on the yield of wheat (Triticum aestivum L.) in dryland farming regions of the Loess Plateau in China. Mulching has proven to be an effective practice to increase crop yield, and possibly contribute to replenishing groundwater. This evaluation study collected and analyzed the data of 1849 observations...

A van der Waals-like Transition Between Normal and Cancerous Phases in Cell Populations Dynamics of Colorectal Cancer

Based on a deterministic continuous model of cell populations dynamics in the colonic crypt and in colorectal cancer, we propose four combinations of feedback mechanisms in the differentiations from stem cells (SCs) to transit cells (TCs) and then to differentiated cells (DCs), the four combinations include the double linear (LL), the linear and saturating (LS), the saturating...

Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells

conceived and designed the research. Shan-shan Meng wrote and edited the manuscript. Shan-shan Meng, Rong Gao, Bing-di Yan, Jin Ren, Fei Wu, Peng Chen, Jie Zhang, Li-fang Wang, Yuan-ming Xiao, Jing Liu make

The rs2237892 Polymorphism in KCNQ1 Influences Gestational Diabetes Mellitus and Glucose Levels: A Case-Control Study and Meta-Analysis

Objective Recent genetic studies have shown that potassium voltage-gated channel, KQT-like subfamily, member1 (KCNQ1) gene is related to gestational diabetes mellitus (GDM). However, studies for the rs2237892 polymorphism in KCNQ1 and GDM remain conflicting in Asians. Furthermore, associations of this polymorphism with glucose levels during oral glucose tolerance test (OGTT) have...

Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy

Men exhibit a worse survival rate than premenopausal women after intracerebral hemorrhage (ICH), however, no sex-specific management has been concerned. In a rat model involving infusion of ferrous citrate (FC) that simulates iron accumulation after hemorrhage, a higher degree of autophagy associated with higher injury severity was observed in striatum of males than in females...

Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier

Li-Fang Wang,5 I-Ming Chu1 1Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 2Department of Orthopedic Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University ... cell; Parkinson's disease; polyethylene imine - open access to scientific and medical research his-chin Wu 3 siang Yu 1 li-Fang Wang 5 I-Ming chu 1 1Department of chemical engineering, National Tsing

Concurrent exposure to a dectin-1 agonist suppresses the Th2 response to epicutaneously introduced antigen in mice

Background Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell differentiation. However, the effects of fungal components on epicutaneous sensitization are unclear. Results In this study, we showed that co-administration of curdlan, a...

Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of Met/PI3k/Akt Pathway and Induction of Apoptosis

-fang Wang,1 Zhong-Qi Wang,1 Ling Xu,1 Fei Cao,3 and Ming-juan Liao1 1Department of Clinical Oncology, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

Antigen-driven bystander effect accelerates epicutaneous sensitization with a new protein allergen

Exposure to protein allergen epicutaneously, inducing a Th2-dominant immune response, sensitizes the host to the development of atopic disease. Antigen-driven bystander effect demonstrates that polarized T cells could instruct naïve T cells to differentiate into T cells with similar phenotype. In this study, we aimed to determine the contribution of antigen-driven bystander...

ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations

Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping...

The association between lung innate immunity and differential airway antigen- specific immune responses

Jong-Ylh Lin 0 Li-Fang Wang 0 Rong-Hwa Lin 0 0 Graduate Institutes of Microbiology and Immunology, College of Medicine, National Taiwan University , Jen Ai Road, 1st Section , Taipei, Taiwan , ROC