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Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension

Pulmonary hypertension (PH) contributes to the mortality of patients with lung and heart diseases. However, the underlying mechanism has not been completely elucidated. Accumulating evidence suggests that inflammatory response may be involved in the pathogenesis of PH. Macrophage migration inhibitory factor (MIF) is a critical upstream inflammatory mediator which promotes a broad...

Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension

Pulmonary hypertension (PH) contributes to the mortality of patients with lung and heart diseases. However, the underlying mechanism has not been completely elucidated. Accumulating evidence suggests that inflammatory response may be involved in the pathogenesis of PH. Macrophage migration inhibitory factor (MIF) is a critical upstream inflammatory mediator which promotes a broad...

Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis

Liu Xuan Zhou Guo-Bing Xie Mu-Yan Cai Yan Li Jing-Ping Yun 0 Equal contributors Department of Pathology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center

Analysis of 3 Algorithms for Syphilis Serodiagnosis and Implications for Clinical Management

Background. Algorithms for the diagnosis of syphilis continue to be a source of great controversy, and numerous test interpretations have perplexed many clinicians. Methods. We conducted a cross-sectional study of 24 124 subjects to analyze 3 syphilis testing algorithms: traditional algorithm, reverse algorithm, and the European Centre for Disease Prevention and Control (ECDC...

Incidence and Risk Factors for the Prozone Phenomenon in Serologic Testing for Syphilis in a Large Cohort

Background. The prozone phenomenon is known to be associated with high antibody titers; other associations, such as host factors, have not been elucidated. Methods. A retrospective analysis was conducted to evaluate the incidence of the prozone phenomenon of the syphilis rapid plasma reagin (RPR) test among 46 856 clinical samples, between June 2010 and June 2013. Logistic...

miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1

Breast cancer is the leading cause of cancer death among females, with tumor metastasis being primarily responsible for breast cancer-associated mortality. Current literatures have shown that microRNAs (miRNAs) are implicated in tumor metastasis. In this study, we found that the expression of miR-720 was significantly downregulated in primary breast cancer, with greater...

Factors Associated with Serological Cure and the Serofast State of HIV-Negative Patients with Primary, Secondary, Latent, and Tertiary Syphilis

Background Some syphilis patients remain in a serologically active state after the recommended therapy. We currently know too little about the characteristics of this serological response. Methods We conducted a cohort study using the clinical database from Zhongshan Hospital, Medical College of Xiamen. In total, 1,327 HIV-negative patients with primary, secondary, latent, and...

Use of transcriptome sequencing to understand the pistillate flowering in hickory (Carya cathayensis Sarg.)

Background Different from herbaceous plants, the woody plants undergo a long-period vegetative stage to achieve floral transition. They then turn into seasonal plants, flowering annually. In this study, a preliminary model of gene regulations for seasonal pistillate flowering in hickory (Carya cathayensis) was proposed. The genome-wide dynamic transcriptome was characterized via...

Development of a test strip for rapid detection of lactoperoxidase in raw milk

-ming CHENG, Li-li LIU, Xiao-na ZHANG, Zhan-mei JIANG, and Xiao-xi XU declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by

CXCL13 chemokine as a promising biomarker to diagnose neurosyphilis in HIV-negative patients

Background Chemokine ligand 13 (CXCL13) is believed to play a role in the recruitment of B cells in the central nervous system during neuroinflammation. Neurosyphilis is a group of clinical syndromes of the central nervous system caused by Treponema pallidum (T. pallidum) infection. The relationship between CXCL13 and neurosyphilis still needs further study. In our study, CSF and...

Robust Control for Singular Time-Delay Systems via Parameterized Lyapunov Functional Approach

University, Xi’an 710062, China Received 22 July 2014; Revised 18 September 2014; Accepted 23 September 2014; Published 27 November 2014 Academic Editor: Mathiyalagan Kalidass Copyright © 2014 Li-li Liu

Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

. Data Availability Statement; All relevant data are within the paper - OPEN ACCESS Funding: The authors received no specific funding for this work. Authors Wen-Jie Tao, Li-Li Liu, ZhenDuo Shen, Yan-Yan ... of post-translational Competing Interests: The authors have the following interests: Authors Yan-Yan Zhao, Wan-Hui Liu, Wen-Jie Tao, Li-Li Liu and Zhen-Duo Shen are employed by Luye Pharma Group Ltd

Serological Response Predicts Normalization of Cerebrospinal Fluid Abnormalities at Six Months after Treatment in HIV-Negative Neurosyphilis Patients

Province, ChinaYao Xiao, Man-Li Tong, Li-Rong Lin, Li-Li Liu, Kun Gao, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Tian-Ci Yang & Jian-Jun NiuXiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian ... Province, ChinaYao XiaoInstitute of Infectious Disease, Medical College of Xiamen University, Xiamen, Fujian Province, ChinaMan-Li Tong, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang & Jian-Jun NiuXiamen Zhongshan

Whole genome sequence of the Treponema pallidum subsp. pallidum strain Amoy: An Asian isolate highly similar to SS14

: Man-Li Tong, Jian-Jun Niu, Zhi-Liang Ji, Tian-Ci Yang. Data curation: Qiang Zhao, Li-Li Liu, Hui-Lin Zhang. Formal analysis: Qiang Zhao, Xiao-Zhen Zhu, Kun Gao. Funding acquisition: Man-Li Tong, Li ... -Li Liu, Li-Rong Lin, Jian-Jun Niu, Tian-Ci Yang. Investigation: Li-Li Liu. Methodology: Qiang Zhao, Kun Gao, Hui-Lin Zhang, Li-Rong Lin. Project administration: Tian-Ci Yang. Resources: Xiao-Zhen

Mechanisms of P-Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba

Copyright © 2017 Li-Li Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... ’ Contributions Li-Li Liu and Yong-Mei Guan contributed equally to this study and share first authorship. Acknowledgments This study was supported by the National Natural Science Foundation of China (Grant no

Mechanisms of P-Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba

Copyright © 2017 Li-Li Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... ’ Contributions Li-Li Liu and Yong-Mei Guan contributed equally to this study and share first authorship. Acknowledgments This study was supported by the National Natural Science Foundation of China (Grant no

Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma

Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma Yong-bo Xiao,1,2,* Shao-hang Cai,1,2,* Li-li Liu,1,2 Xia Yang,1,2