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9 papers found.
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Study on Bottom Damp-Proof Method of Cave Dwelling

The cave dwelling, as one of the most typical and traditional characteristic local housing styles in the loess area of Northwest China, has been adopted widely in many areas since ancient times. The construction of the cave dwellings supports environmental protection, makes use of innovative construction technology, and preserves historical cultural heritage. The cave dwellings...

Study on Bottom Damp-Proof Method of Cave Dwelling

The cave dwelling, as one of the most typical and traditional characteristic local housing styles in the loess area of Northwest China, has been adopted widely in many areas since ancient times. The construction of the cave dwellings supports environmental protection, makes use of innovative construction technology, and preserves historical cultural heritage. The cave dwellings...

Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

Esophageal cancer is a high incident cancer worldwide with poor survival and limited therapeutic options. Alterations of microRNAs are common in cancers, and many of these micro RNAs are potential therapeutic and diagnostic targets to treat these cancers. miR-10b-3p located in chromosome region 2q31.1, and its expression is frequently increased in esophageal squamous cell...

CpLEPA Is Critical for Chloroplast Protein Synthesis Under Suboptimal Conditions in Arabidopsis thaliana

LEPA is one of the most conserved translation factors and is found from bacteria to higher plants. However, the physiological function of the chloroplast LEPA homolog in higher plants remains unknown. Herein, we demonstrate the physiological role of cpLEPA in enabling efficient photosynthesis in higher plants. The cplepa-1 mutant displays slightly high chlorophyll fluorescence...

Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity

Background Celastrol, a plant triterpene, is known to play important role in inhibiting proliferation and inducing apoptosis of gastric cancer cells. In the present study, the mechanism of celastrol on gastric cancer cells apoptosis was examined. Methods We assessed effect of celastrol on NF-κB signaling pathway in gastric cancer cells using western blot and luciferase reporter...

Second Moment Convergence Rates for Uniform Empirical Processes

Let be a sequence of independent and identically distributed -distributed random variables. Define the uniform empirical process as , . In this paper, we get the exact convergence rates of weighted infinite series of .

ASDCD: Antifungal Synergistic Drug Combination Database

Finding effective drugs to treat fungal infections has important clinical significance based on high mortality rates, especially in an immunodeficient population. Traditional antifungal drugs with single targets have been reported to cause serious side effects and drug resistance. Nowadays, however, drug combinations, particularly with respect to synergistic interaction, have...

A phase I study of ridaforolimus in adult Chinese patients with advanced solid tumors

Ridaforolimus (AP23573, MK-8669 or deforolimus) is an inhibitor of mammalian target of rapamycin (mTOR), an important regulator in the cell survival pathway. This open-label, single center phase I study aimed to investigate the pharmacokinetic (PK) and safety profiles of ridaforolimus in Chinese patients with treatment-refractory advanced or relapsed solid tumors. The PK data...

Inhibition of cellular transformation by triphenylmethane: a novel chemopreventive agent

Triphenyhuethane (TPM) was found to inhibit 3-methyl-cholanthrene-induced neoplastic transformation of 10T1/2 cells in a dose-dependent manner (ED50 = 2.8 μM). This activity was independent of any effect on intercellular communication and did not appear to be directly related to the general antioxidant properties of TPM as measured by cellular thiobarbituric acid-reactive...