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Search: authors:"Libo Yu-Taeger"

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Sexual behavior and testis morphology in the BACHD rat model

, Huu Phuc Nguyen. Visualization: Arianna Novati, Libo Yu-Taeger, Irene Gonzalez Menendez. Writing ± original draft: Arianna Novati. Writing ± review & editing: Arianna Novati, Libo Yu-Taeger, Irene

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

White matter (WM) atrophy is a significant feature of Huntington disease (HD), although its aetiology and early pathological manifestations remain poorly defined. In this study, we aimed to characterize WM-related features in the transgenic YAC128 and BACHD models of HD. Using diffusion tensor magnetic resonance imaging (DT-MRI), we demonstrate that microstructural WM...

Early Deficits in Glycolysis Are Specific to Striatal Neurons from a Rat Model of Huntington Disease

In Huntington disease (HD), there is increasing evidence for a link between mutant huntingtin expression, mitochondrial dysfunction, energetic deficits and neurodegeneration but the precise nature, causes and order of these events remain to be determined. In this work, our objective was to evaluate mitochondrial respiratory function in intact, non-permeabilized, neurons derived...