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21 papers found.
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Impact of hypophosphatemia on outcome of patients in intensive care unit: a retrospective cohort study

Hypophosphatemia generally occurs in Intensive Care Units (ICUs), but its impact is often ignored. The aim of this study was to investigate whether hypophosphatemia can be a risk factor for ICU 28-day mortality. A single-center retrospective cohort study was conducted by collecting data from 1073 patients admitted to general ICU and then presented to the Sixth Affiliated Hospital...

Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen

, Yunnan, ChinaShengtao Fan, Yun Liao, Guorun Jiang, Lichun Wang, Xingli Xu, Min Feng, Ying Zhang & Qihan LiAimei Convac BioPharm (Jiangsu) Co., Ltd., 225300, Taizhou, Jiangsu, ChinaYaru Lian, Li Jiang ... • Google Scholar Search for Chenhong Dong in:Nature Research journals • PubMed • Google Scholar Search for Erxia Yang in:Nature Research journals • PubMed • Google Scholar Search for Lichun Wang in:Nature

Extrinsic Least Squares Regression with Closed-Form Solution on Product Grassmann Manifold for Video-Based Recognition

, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116024, China Correspondence should be addressed to Lichun Wang; nc.ude.tujb@clgnaw Received 21 August 2017; Accepted 30

Extrinsic Least Squares Regression with Closed-Form Solution on Product Grassmann Manifold for Video-Based Recognition

, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116024, China Correspondence should be addressed to Lichun Wang; nc.ude.tujb@clgnaw Received 21 August 2017; Accepted 30

The mutated tegument protein UL7 attenuates the virulence of herpes simplex virus 1 by reducing the modulation of α-4 gene transcription

Background UL7, a tegument protein of Herpes Simplex Virus type I (HSV-1), is highly conserved in viral infection and proliferation and has an unknown mechanism of action. Methods A HSV-1 UL7 mutant (UL7-MU) was constructed using the CRISPR-cas9 system. The replication rate and plaque morphology were used to analyze the biological characteristics of the wild-type (WT), UL7-MU and...

Stability and toxicity of empty or gene-loaded lipopolysaccharide-amine nanopolymersomes

Stability and toxicity of empty or gene-loaded lipopolysaccharide-amine nanopolymersomes Qinmei Wang,1,* Ying Chen,1,* Lichun Wang,1 Xinchun Zhang,2 Hongzhang Huang,2 Wei Teng2 1Key Laboratory on

Colonic involvement in disseminated histoplasmosis of an immunocompetent adult: case report and literature review

Background Histoplasmosis is a common opportunistic fungal infection that is observed almost exclusively in immunodeficient patients, especially those with AIDS. Immunocompetent individuals that suffer from histoplasmosis are rarely reported, especially those with disseminated lesions, such as disseminated histoplasmosis. The observation of disseminated histoplasmosis with...

A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes

Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. In addition, prior work has suggested that Kaposi’s sarcoma-associated herpesvirus (KSHV) is capable of regulating cellular gene transcription by miRNA. We...

The Modulation of Phosphatase Expression Impacts the Proliferation Efficiency of HSV-1 in Infected Astrocytes

Herpes Simplex Virus 1 (HSV-1) is a major pathogen that causes human neurological diseases, including herpes simplex encephalitis (HSE). Previous studies have shown that astrocytes are involved in HSV-1 systemic pathogenesis in the central nervous system (CNS), although the mechanism remains unclear. In this study, a high-throughput RNAi library screening method was used to...

HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2

The protein encoded by HSRG1 (HSV-1 stimulation-related gene 1) is a virally induced protein expressed in HSV-1-infected cells. We have already reported that HSRG1 is capable of interacting with transcriptional regulator proteins. To further analyze the effects of HSRG1 on the regulation of viral gene transcription, we expressed the HSRG1 protein in transfected cells and found...

Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein

HSV-1 viral capsid maturation and egress from the nucleus constitutes a self-controlled process of interactions between host cytoplasmic membrane proteins and viral capsid proteins. In this study, a member of the tetraspanin superfamily, CTMP-7, was shown to physically interact with HSV-1 protein VP26, and the VP26-CTMP-7 complex was detected both in vivo and in vitro. The...

Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein

HSV-1 viral capsid maturation and egress from the nucleus constitutes a self-controlled process of interactions between host cytoplasmic membrane proteins and viral capsid proteins. In this study, a member of the tetraspanin superfamily, CTMP-7, was shown to physically interact with HSV-1 protein VP26, and the VP26-CTMP-7 complex was detected both in vivo and in vitro. The...

The Gene Expression Profile of Peripheral Blood Mononuclear Cells from EV71-Infected Rhesus Infants and the Significance in Viral Pathogenesis

Enterovirus 71 (EV71) is the major pathogen responsible for fatal hand, foot and mouth disease (HFMD). Our previous work reported on an EV71-infected rhesus monkey infant model that presented with histo-pathologic changes of the central nervous system (CNS) and lungs. This study is focused on the correlated modulation of gene expression in the peripheral blood mononuclear cells...

A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)

Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with...

Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation

Background Exposure to particulate matter (PM) is a significant risk factor for increased cardiopulmonary morbidity and mortality. The mechanism of PM-mediated pathophysiology remains unknown. However, PM is proinflammatory to the endothelium and increases vascular permeability in vitro and in vivo via ROS generation. Objectives We explored the role of tight junction proteins as...

Immunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations

Background To investigate the long-term effects on immunity of an inactivated enterovirus 71 (EV71) vaccine and its protective efficacy. Methods A sub-cohort of 1,100 volunteers from Guangxi Province in China was eligible for enrolment and randomly administered either the EV71 vaccine or a placebo on days 0 and 28 in a phase III clinical trial and then observed for the following...

Pathogenesis study of enterovirus 71 infection in rhesus monkeys

ChinaYing Zhang, Wei Cui, Longding Liu, Jingjing Wang, Hongling Zhao, Yun Liao, Ruixiong Na, Chenghong Dong, Lichun Wang, Zhongping Xie, Jiahong Gao, Pingfang Cui, Xuemei Zhang & Qihan Li AuthorsSearch for ... for Lichun Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhongping Xie in:Nature Research journals • PubMed • Google ScholarSearch for Jiahong Gao in:Nature Research journals

XEMBL: distributing EMBL data in XML format

Lichun Wang 0 Jean-Jack Riethoven 0 Alan Robinson 0 0 European Bioinformatics Institute , EMBL Outstation - Hinxton, Wellcome Trust Genome Campus , Hinxton, Cambridge , CB10 1SD, UK Summary: Data in

Ligand-induced nuclear translocation of S1P1 receptors mediates Cyr61 and CTGF transcription in endothelial cells

Sphingosine-1-phosphate (S1P) receptor subtype 1 (S1P1), a G-protein coupled receptor (GPCR), regulates many biological activities of endothelial cells (ECs). In this report, we show that S1P1 receptors are present in the nuclei of ECs by using various biochemical and microscopic techniques such as cellular fractionation, immunogold labeling, and confocal microscopic analysis...

Study of the Integrated Immune Response Induced by an Inactivated EV71 Vaccine

Enterovirus 71 (EV71), a major causative agent of hand-foot-and-mouth disease (HFMD), causes outbreaks among children in the Asia-Pacific region. A vaccine is urgently needed. Based on successful pre-clinical work, phase I and II clinical trials of an inactivated EV71 vaccine, which included the participants of 288 and 660 respectively, have been conducted. In the present study...