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21 papers found.
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Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation

BackgroundInfectious complications are a major cause of morbidity and mortality after heart transplantation (HT). However, the epidemiology and outcomes of these infections in the recent population of adult heart transplant recipients have not been investigated.MethodsWe conducted a single-center retrospective study on infectious complications occurring within 180 days following...

Impact of transfusion on patients with sepsis admitted in intensive care unit: a systematic review and meta-analysis

Adrie Antoine Gros Michael Darmon Lila Bouadma 0 Jean‑François Timsit jean‑ 0 0 UMR 1137 ‐ IAME Team 5 - DeSCID: Decision Sciences in Infectious Diseases, Control and Care Inserm/Univ Paris Diderot

Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects

Background Oxacillin and cloxacillin are the most frequently used penicillins for the treatment of severe methicillin-susceptible Staphylococcus aureus infections in intensive care units (ICUs), especially endocarditis. International recommendations do not suggest any adaptation of the dosage in case of renal impairment. We wanted to assess the risk factors for overdosing in ICU...

Respective impact of implementation of prevention strategies, colonization with multiresistant bacteria and antimicrobial use on the risk of early- and late-onset VAP: An analysis of the OUTCOMEREA network

Barbier (medical-surgical ICU, Orleans, France), Jean-Pierre Bedos (ICU, Versailles Hospital, Versailles, France); Julien Bohe (ICU, HoÃpital Pierre Benite, Lyon France), Lila Bouadma (ICU, Bichat Hospital ... . Methodology: Wafa Ibn Saied, Lila Bouadma, Jean-Francois Timsit. Resources: Maite Garrouste-Orgeas, Michael Darmon, Yves Cohen, Elie Azoulay, Carole Schwebel, Aguila Radjou, Hatem Kallel, Guillaume Marcotte

What procalcitonin brings to management of sepsis in the ICU

Michel Wolff 0 Lila Bouadma 0 0 Service de Reanimation Medicale et des Maladies Infectieuses and EA 3964, Universite Paris 7-Paris Diderot, Hopital Bichat-Claude-Bernard, Assistance Publique

Reply to Cadena et al

. Acknowledgments Potential conflicts of interest. All authors: no conflicts. Jean-Christophe Lucet and Lila Bouadma

Management of neurological complications of infective endocarditis in ICU patients

Patients with infective endocarditis (IE) are generally referred to the intensive care unit (ICU) for one or more organ dysfunctions caused by complications of IE. Neurologic events are frequent causes of ICU admission in patients with IE. They can arise through various mechanisms consisting of stroke or transient ischemic attack, cerebral hemorrhage, mycotic aneurysm, meningitis...

Treatment of bloodstream infections in ICUs

Bloodstream infections (BSIs) are frequent in ICU and is a prognostic factor of severe sepsis. Community acquired BSIs usually due to susceptible bacteria should be clearly differentiated from healthcare associated BSIs frequently due to resistant hospital strains. Early adequate treatment is key and should use guidelines and direct examination of samples performed from the...

Guidewire exchange vs new site placement for temporary dialysis catheter insertion in ICU patients: is there a greater risk of colonization or dysfunction?

Background Intensive care unit (ICU) patients require dialysis catheters (DCs) for renal replacement therapy (RRT). They carry a high risk of developing end-stage renal disease, and therefore their vascular access must be preserved. Guidewire exchange (GWE) is often used to avoid venipuncture insertion (VPI) at a new site. However, the impact of GWE on infection and dysfunction...

The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs

Post-intensive care syndrome includes the multiple consequences of an intensive care unit (ICU) stay for patients and families. It has become a new challenge for intensivists. Prevention programs have been disappointing, except for ICU diaries, which report the patient’s story in the ICU. However, the effectiveness of ICU diaries for patients and families is still controversial...

Severe varicella-zoster virus pneumonia: a multicenter cohort study

Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP). This was an observational study of patients with VZV-CAP admitted to 29 intensive care units...

Decreased Risk of Ventilator-Associated Pneumonia in Sepsis Due to Intra-Abdominal Infection

Rationale Experimental studies suggest that intra-abdominal infection (IAI) induces biological alterations that may affect the risk of lung infection. Objectives To investigate the potential effect of IAI at ICU admission on the subsequent occurrence of ventilator-associated pneumonia (VAP). Methods We used data entered into the French prospective multicenter Outcomerea database...

Prognostic value of procalcitonin in respiratory tract infections across clinical settings

Alexander Kutz 0 Matthias Briel Mirjam Christ-Crain Daiana Stolz Lila Bouadma Michel Wolff Kristina B Kristoffersen Long Wei Olaf Burkhardt Tobias Welte Stefan Schroeder Vandack Nobre Michael Tamm Neera

Prognostic value of procalcitonin in respiratory tract infections across clinical settings

Whether the inflammatory biomarker procalcitonin provides prognostic information across clinical settings and different acute respiratory tract infections (ARIs) is poorly understood. In the present study, we investigated the prognostic value of admission procalcitonin levels to predict adverse clinical outcome in a large ARI population. We analysed data from 14 trials and 4,211...

Long-Term Impact of a Multifaceted Prevention Program on Ventilator-Associated Pneumonia in a Medical Intensive Care Unit

Background. Ventilator-associated pneumonia (VAP), the most common hospital-acquired infection in intensive care units, increases mortality and health care costs. We describe the long-term impact of a multifaceted program for decreasing VAP rates that markedly improved compliance with 8 targeted preventive measures. Methods. We compared VAP rates during a 45-month baseline period...

Personal Decision-Making Criteria Related to Seasonal and Pandemic A(H1N1) Influenza-Vaccination Acceptance among French Healthcare Workers

Background Influenza-vaccination rates among healthcare workers (HCW) remain low worldwide, even during the 2009 A(H1N1) pandemic. In France, this vaccination is free but administered on a voluntary basis. We investigated the factors influencing HCW influenza vaccination. Methods In June–July 2010, HCW from wards of five French hospitals completed a cross-sectional survey. A...

Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis

Background. Procalcitonin algorithms may reduce antibiotic use for acute respiratory tract infections (ARIs). We undertook an individual patient data meta-analysis to assess safety of this approach in different ARI diagnoses and different clinical settings. Methods. We identified clinical trials in which patients with ARI were assigned to receive antibiotics based on a...

Levels of Vancomycin in Cerebrospinal Fluid of Adult Patients Receiving Adjunctive Corticosteroids to Treat Pneumococcal Meningitis: A Prospective Multicenter Observational Study

Background. Evidence from a recent randomized controlled trial suggests that dexamethasone as adjunct therapy in adult pneumococcal meningitis reduces mortality and neurological sequelae. However, adding dexamethasone has the potential to reduce penetration of vancomycin into the cerebrospinal fluid (CSF). We sought to determine concentrations of vancomycin in serum and CSF of...