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Predictors of Infant Age at Enrollment in Early Infant Diagnosis Services in Kenya

Despite the importance of early detection to signal lifesaving treatment initiation for HIV+ infants, early infant diagnosis (EID) services have received considerably less attention than other aspects of prevention of mother to child transmission care. This study draws on baseline data from an on-going cluster randomized study of an intervention to improve EID services at six...

Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans

; Xiao-dong LIU and Lin XIE reviewed and revised the manuscript; and Jun-lin CHENG, Hong-wei FAN, and Da-wei XIAO participated in the clinical study and reviewed the manuscript. References 1. Ye H, Wu ... (Group) Co Ltd, Shanghai 201203, ChinaHai-yan LiuDepartment of Clinical Pharmacology, Nanjing First Hospital, Nanjing 210006, ChinaJun-lin Cheng, Hong-wei Fan & Da-wei Xiao AuthorsSearch for Li Liu

Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis

The prognostic importance of examining ErbB receptor family expression in human bladder cancer remains uncertain. Using published evidence, we examined the clinical value and the updated results of clinical trials targeting ErbB receptor family members. Twenty-seven articles from 65 references related to ErbB receptor expression assessment in bladder cancer were reviewed. The...

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Final Results of a Phase III Randomized Clinical Trial

BackgroundThis randomized phase III study was to evaluate the efficacy and safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of peritoneal carcinomatosis (PC) from gastric cancer.MethodsSixty-eight gastric PC patients were randomized into CRS alone (n = 34) or CRS + HIPEC (n = 34) receiving cisplatin 120 mg and...

Variations of fish composition and diversity related to environmental variables in shallow lakes in the Yangtze River basin

Variations in fish communities of shallow lakes in the Yangtze basins were investigated from September 2007 to September 2009. Six lakes were chosen for comparative study of species composition and diversity in relation to environmental variations. Lake heterogeneity was described with environmental physico-chemical variables, using principal component analysis. Sixteen families...

Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis

alpha and opioids in the disease . J Neuroimmunol 1994 , 51 : 169 - 176 . Correspondence Lin-Cheng Yang MD , Associate Professor , Gene Therapy Laboratory, Tajen Institute of Technology, Pingtung, 907

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Hongwei Tian 0 Gang Shi 0 Guoyou Yang Junfeng Zhang Yiming Li Tao Du Jianzhou Wang Fen Xu Lin Cheng Xiaomei Zhang Lei Dai Xiaolei Chen Shuang Zhang Yang Yang Dechao Yu Yuquan Wei Hongxin Deng 0

RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

Jin-Qiu Xue 0 Tian-Song Xia 0 Xiu-Qing Liang Wenbin Zhou Lin Cheng Liang Shi Ying Wang Qiang Ding 0 Equal contributors Jiangsu Breast Disease Center, the First Affiliated Hospital with Nanjing

Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer

Background Endometrial cancers (ECs) are the most common form of gynecologic malignancy. Recent studies have reported that ECs reveal distinct markers for molecular pathogenesis, which in turn is linked to the various histological types of ECs. To understand further the molecular events contributing to ECs and endometrial tumorigenesis in general, a more precise identification of...

MAGIC Study: Aims, Design and Methods using SystemCHANGE™ to Improve Immunosuppressive Medication Adherence in Adult Kidney Transplant Recipients

Shirley Moore 3 Donna Hathaway 1 An-Lin Cheng 0 Guoqing Chen 5 Kathy Goggin 4 0 School of Nursing and Health Studies, University of Missouri-Kansas City , Health Sciences Building 2407, Kansas City, MO

Treadmill exercise enhances therapeutic potency of transplanted bone mesenchymal stem cells in cerebral ischemic rats via anti-apoptotic effects

Background The transplantation of bone marrow stromal cells (MSCs) has proved to ameliorate ischemic brain injury in animals, but most transplanted MSCs undergo apoptosis in the ischemic penumbra, greatly compromising the therapeutic value of this treatment. Meanwhile, cell apoptosis can be inhibited by post-ischemia exercise which has been demonstrated to improve the expression...

Intrathecal bupivacaine with morphine or neostigmine for postoperative analgesia after total knee replacement surgery

Ping-Heng Tan Yuan-Yi Chia Yuan Lo Kang Liu Lin-Cheng Yang Tsung-Hsing Lee [L'administration intrathcale de bupivacane avec morphine ou nostigmine comme analgsie postopratoire suivant la mise en

Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells

Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells and increased in lymph node metastatic cancer. Mechanistically, we found that...

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

G-protein-coupled receptor 48 (GPR48) is an orphan receptor belonging to the G-protein-coupled receptors family, which plays an important role in the development of various organs and cancer development and progression such as gastric cancer and colorectal cancer (CRC). However, the prognostic value of GPR48 expression in patients with CRC has not been reported. In this study, we...

Reciprocal activation of macrophages and breast carcinoma cells by nitric oxide and colony-stimulating factor-1

Induction of inducible nitric oxide synthase (iNOS) gene expression, nitric oxide (NO) production and migration of RAW264.7 macrophages by coculture with breast cancer MDA-MB-231 cells or the addition of conditioned medium derived from MDA-MB-231 cells (MDA-CM) was identified. Increased iNOS/NO induction and migration of macrophages by MDA-CM were significantly blocked by adding...

An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells

Homodimerization of RON (MST1R), a receptor tyrosine kinase, usually occurs in cells stimulated by a ligand and leads to the downstream activation of signaling pathways. Here we report that bladder cancer cells, in response to physiological stress, use an alternative mechanism for signaling activation. Time-course studies indicated that RON migrated directly from the membrane to...

Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells

Glioblastoma (GBM) is the most malignant and lethal brain tumor harboring glioma stem cells (GSCs) that promote tumor propagation and therapeutic resistance. GSCs preferentially express several critical cell surface molecules that regulate the pro-survival signaling for maintaining the stem cell-like phenotype. Tetraspanin CD9 has recently been reported as a GSC biomarker that is...

Effect of casting methods on microstructure and mechanical properties of ZM5 space flight magnesium alloy

AuthorsAuthors and affiliations Xu-liang ZhangGuo-kang YuWen-bing ZouYan-shuo JiYing-zhuo LiuJia-lin Cheng Research & Development First Online: 13 December 2018 5 Downloads Abstract The counter

Role of Benzathine Penicillin G in Prophylaxis for Recurrent Streptococcal Cellulitis of the Lower Legs

Cellulitis of the lower leg is an infection caused by streptococci or, less commonly, Staphylococcus aureus and other gram-negative rods. Recurrence of cellulitis is a common problem. In the present study, we evaluated the use of monthly intramuscular injections of benzathine penicillin G to prevent recurrences of cellulitis. A total of 115 patients with definite or presumptive...