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The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

• Google Scholar Search for Luke J. Mortensen in:Nature Research journals • PubMed • Google Scholar Search for Charles P. Lin in:Nature Research journals • PubMed • Google Scholar Search for Linheng Li

Regulation of hematopoietic stem cells in the niche

Hematopoiesis provides a suitable model for understanding adult stem cells and their niche. Hematopoietic stem cells (HSCs) continuously produce blood cells through orchestrated proliferation, self-renewal, and differentiation in the bone marrow (BM). Within the BM exists a highly organized microenvironment termed “niche” where stem cells reside and are maintained. HSC niche is...

Beta-catenin cleavage enhances transcriptional activation

She in:Nature Research journals • PubMed • Google Scholar Search for Linheng Li in:Nature Research journals • PubMed • Google Scholar Search for Terrence A. Barrett in:Nature Research journals

Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase

Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of NAMPT in these physiological and pathological processes are not...

Developmental Programming of Long Non-Coding RNAs during Postnatal Liver Maturation in Mice

The liver is a vital organ with critical functions in metabolism, protein synthesis, and immune defense. Most of the liver functions are not mature at birth and many changes happen during postnatal liver development. However, it is unclear what changes occur in liver after birth, at what developmental stages they occur, and how the developmental processes are regulated. Long non...

Heterogeneity, Self-Renewal, and Differentiation of Hematopoietic Stem Cells

niches in HSC biology and fate and in the use of HSCs in disease treatment. Roland Jurecic Linheng Li R. Keith Humphries

Stem cells, niche, and zones

Medical Center in New York mentored by Dr Edward Ziff. From 1995-1999 Linheng was a postdoctoral fellow in the laboratory of Dr Leroy Hood. Linheng Li opened his own laboratory at the Stowers Institute for ... organisms with long life span. - Medical Center. Linheng Li research investigates the molecular and cellular mechanisms that regulate adult stem cell development in the hematopoietic and intestinal tissues

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

• Google ScholarSearch for Linheng Li in:Nature Research journals • PubMed • Google ScholarSearch for Matthias G. Stelzner in:Nature Research journals • PubMed • Google ScholarSearch for James C. Y. Dunn

Stem cells and their niche: an inseparable relationship

Ting Xie 0 Linheng Li 0 0 Stowers Institute for Medical Research , 1000 East 50th Street, Kansas City, MO 64110 , USA A recent Keystone symposium on 'Stem Cell Interactions with their ... activity via the production of angiotensin. N-cadherin is expressed at the junction between HSCs and the osteoblastic niche (Zhang et al., 2003). Linheng Li (Stowers Institute, Kansas City, MO, USA

Intestinal Subepithelial Myofibroblasts Support the Growth of Intestinal Epithelial Stem Cells

Linheng Li Michael Lewis Matthias Stelzner James C. Y. Dunn Martn G. Martn Jun Sun, Rush University Medical Center, United States of America Intestinal epithelial stem cells (ISCs) are the focus of recent

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

Wiedemann in:Nature Research journals • PubMed • Google ScholarSearch for Yuji Mishina in:Nature Research journals • PubMed • Google ScholarSearch for Linheng Li in:Nature Research journals • PubMed • Google ... Scholar Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Linheng Li. Supplementary information PDF files1.Supplementary Fig. 1 Western

Identification of the haematopoietic stem cell niche and control of the niche size

Medical Center, Kansas City, Kansas 66160, USALeanne M. Wiedemann & Linheng Li AuthorsSearch for Jiwang Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Chao Niu in:Nature Research ... Mishina in:Nature Research journals • PubMed • Google ScholarSearch for Linheng Li in:Nature Research journals • PubMed • Google Scholar Competing interests The authors declare that they have no competing