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A Role for the Budding Yeast Separase, Esp1, in Ty1 Element Retrotransposition

Separase/Esp1 is a protease required at the onset of anaphase to cleave cohesin and thereby enable sister chromatid separation. Esp1 also promotes release of the Cdc14 phosphatase from the nucleolus to enable mitotic exit. To uncover other potential roles for separase, we performed two complementary genome-wide genetic interaction screens with a strain carrying the budding yeast...

A Simple Spatial Working Memory and Attention Test on Paired Symbols Shows Developmental Deficits in Schizophrenia Patients

People with neuropsychiatric disorders such as schizophrenia often display deficits in spatial working memory and attention. Evaluating working memory and attention in schizophrenia patients is usually based on traditional tasks and the interviewer’s judgment. We developed a simple Spatial Working Memory and Attention Test on Paired Symbols (SWAPS). It takes only several minutes...

A novel DNA sequence periodicity decodes nucleosome positioning

There have been two types of well-characterized DNA sequence periodicities; both are found to be associated with important molecular mechanisms. One is a 3-nt periodicity corresponding to codon triplets, the other is a 10.5-nt periodicity related to the structure of DNA helixes. In the process of analyzing the genome and transcriptome of Trichomonas vaginalis, we observed a 120.9...

A quality evaluation strategy for Rhizoma coptidis from a variety of different sources using chromatographic fingerprinting combined with biological fingerprinting

Most of herbal medicines of different sources are used for the same treatment goal in clinic despite their tremendous differences of the quality. Because the clinical efficacy is closely related to the quality of medicines, the implementation of an effective quality control (QC) process is vital. Chemical methods based on content determination and chromatographic fingerprints...

A review and update on orphan drugs for the treatment of noninfectious uveitis

A review and update on orphan drugs for the treatment of noninfectious uveitis Caiyun You,1–3 Haitham F Sahawneh,1,2 Lina Ma,1,2 Buraa Kubaisi,1,2 Alexander Schmidt,1,2 C Stephen Foster1,2,4

An Integrated Analysis of miRNA and mRNA Expressions in Non-Small Cell Lung Cancers

Science and Technology of Zhoushan awarded to Professor Yongkui Zhang (20081059), and the Research Fund of Zhoushan Hospital awarded to Dr. Lina Ma, and the National Basic Research Program (973 Program

Analysis of synonymous codon usage in Hepatitis A virus

Background Hepatitis A virus is the causative agent of type A viral hepatitis, which causes occasional acute hepatitis. Nevertheless, little information about synonymous codon usage pattern of HAV genome in the process of its evolution is available. In this study, the key genetic determinants of codon usage in HAV were examined. Results The overall extent of codon usage bias in...

Characterization of Chinese Haemophilus parasuis Isolates by Traditional Serotyping and Molecular Serotyping Methods

Haemophilus parasuis is classified mainly through serotyping, but traditional serotyping always yields non-typable (NT) strains and unreliable results via cross-reactions. Here, we surveyed the serotype prevalence of Chinese H. parasuis isolates using traditional serotyping (gel immuno-diffusion test, GID) and molecular serotyping (multiplex PCR, mPCR). We also investigated why...

Comparative study of the mycorrhizal root transcriptomes of wild and cultivated rice in response to the pathogen Magnaporthe oryzae

BackgroundRice, which serves as a staple food for more than half of the world’s population, is very susceptible to the pathogenic fungus, Magnaporthe oryzae. However, common wild rice (Oryza rufipogon), which is the ancestor of Asian cultivated rice (O. sativa), has significant potential as a genetic source of resistance to M. oryzae. Recent studies have shown that the...

Contamination of Phthalate Esters (PAEs) in Typical Wastewater-Irrigated Agricultural Soils in Hebei, North China

The Wangyang River (WYR) basin is a typical wastewater irrigation area in Hebei Province, North China. This study investigated the concentration and distribution of six priority phthalate esters (PAEs) in the agricultural soils in this area. Thirty-nine soil samples (0–20 cm) were collected along the WYR to assess the PAE residues in soils. Results showed that PAEs are ubiquitous...

Defining the chromatin signature of inducible genes in T cells

Background Specific chromatin characteristics, especially the modification status of the core histone proteins, are associated with active and inactive genes. There is growing evidence that genes that respond to environmental or developmental signals may possess distinct chromatin marks. Using a T cell model and both genome-wide and gene-focused approaches, we examined the...

Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation

Lina Ma 0 Andrew P. Jarman () 0 0 Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh , George Square, Edinburgh EH8 9XD , UK Summary A significant number of

Effect of Allicin against Ischemia/Hypoxia-Induced H9c2 Myoblast Apoptosis via eNOS/NO Pathway-Mediated Antioxidant Activity

16 April 2018 Academic Editor: Letizia Angiolella Copyright © 2018 Lina Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Effect of Allicin against Ischemia/Hypoxia-Induced H9c2 Myoblast Apoptosis via eNOS/NO Pathway-Mediated Antioxidant Activity

Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester, diallyl thiosulfinate) is the main biologically active ingredient in garlic. The present study investigated the protective effect of allicin against cardiomyocyte apoptosis that was induced by ischemia in vitro and the potential molecular mechanisms that were involved in this antiapoptotic effect. The results indicated...

Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults

Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults Lina Ma, Guiming Sha, Yaxin Zhang, Yun Li Department of Geriatrics, Xuanwu

Epidemiological Characteristics of Hypertension in the Elderly in Beijing, China

Background/Objectives The prevalence rate of hypertension increases significantly with the aging society, and hypertension is obviously becoming a major health care concern in China. The aim of the study was to explore the epidemiological characteristics of hypertension in the elderly and to provide a basis for the prevention of hypertension. Design 3-cross sectional studies in...

Fungal communities in ancient peatlands developed from different periods in the Sanjiang Plain, China

Contributions Conceptualization: Chunjie Tian. Data curation: Xue Zhou. Formal analysis: Lei Tian, Jianfeng Zhang. Funding acquisition: Chunjie Tian. Investigation: Zhenqing Zhang, Lina Ma. Methodology

Ginkgolide B Reduces LOX-1 Expression by Inhibiting Akt Phosphorylation and Increasing Sirt1 Expression in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells

Oxidized low-density lipoprotein (ox-LDL) is an important risk factor in the development of atherosclerosis. LOX-1, a lectin-like receptor for ox-LDL, is present primarily on endothelial cells and upregulated by ox-LDL, tumor necrosis factor a, shear stress, and cytokines in atherosclerosis. Recent studies demonstrated that ginkgolide B, a platelet-activating factor receptor...

Global Analysis of a Model of Viral Infection with Latent Stage and Two Types of Target Cells

By introducing the probability function describing latency of infected cells, we unify some models of viral infection with latent stage. For the case that the probability function is a step function, which implies that the latency period of the infected cells is constant, the corresponding model is a delay differential system. The model with delay of latency and two types of...

Global Analysis of a Model of Viral Infection with Latent Stage and Two Types of Target Cells

By introducing the probability function describing latency of infected cells, we unify some models of viral infection with latent stage. For the case that the probability function is a step function, which implies that the latency period of the infected cells is constant, the corresponding model is a delay differential system. The model with delay of latency and two types of...