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17 papers found.
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A comparative transcriptomic analysis reveals the core genetic components of salt and osmotic stress responses in Braya humilis

Ma. Data curation: Pengshan Zhao. Formal analysis: Pengshan Zhao. Funding acquisition: Pengshan Zhao, Guoxiong Chen. Investigation: Lirong Wang, Xin Zhao, Xiao-Fei Ma. Methodology: Pengshan Zhao ... . Project administration: Pengshan Zhao, Guoxiong Chen. Resources: Pengshan Zhao. Validation: Pengshan Zhao, Lirong Wang. Writing ± original draft: Pengshan Zhao. 11 / 13 Writing ± review & editing

Improved Filter-SQP Algorithm with Active Set for Constrained Minimax Problems

19 July 2014; Accepted 25 August 2014; Published 2 September 2014 Academic Editor: Kazutake Komori Copyright © 2014 Zhijun Luo and Lirong Wang. This is an open access article distributed under the

A Globally Convergent Parallel SSLE Algorithm for Inequality Constrained Optimization

; Accepted 2 March 2014; Published 3 April 2014 Academic Editor: Cedric Yiu Copyright © 2014 Zhijun Luo and Lirong Wang. This is an open access article distributed under the Creative Commons Attribution

A Globally Convergent Parallel SSLE Algorithm for Inequality Constrained Optimization

; Accepted 2 March 2014; Published 3 April 2014 Academic Editor: Cedric Yiu Copyright © 2014 Zhijun Luo and Lirong Wang. This is an open access article distributed under the Creative Commons Attribution

A Simple SQP Algorithm for Constrained Finite Minimax Problems

; Published 10 February 2014 Academic Editors: Z.-C. Deng, K. Skouri, and K.-C. Ying Copyright © 2014 Lirong Wang and Zhijun Luo. This is an open access article distributed under the Creative Commons

Modeling skin sensitization potential of mechanistically hard-to-be-classified aniline and phenol compounds with quantum mechanistic properties

Background Advanced structure-activity relationship (SAR) modeling can be used as an alternative tool for identification of skin sensitizers and in improvement of the medical diagnosis and more effective practical measures to reduce the causative chemical exposures. It can also circumvent ethical concern of using animals in toxicological tests, and reduce time and cost. Compounds...

Modeling skin sensitization potential of mechanistically hard-to-be-classified aniline and phenol compounds with quantum mechanistic properties

properties Qin Ouyang†1, 4, Lirong Wang†1, Ying Mu3 and Xiang-Qun Xie1, 2Email author †Contributed equally BMC Pharmacology and Toxicology201415:76 https://doi.org/10.1186/2050-6511-15-76 ©  Ouyang et ... “allergic potential” of drugs. Notes Qin Ouyang, Lirong Wang contributed equally to this work. Abbreviations ACD:  Allergic contact dermatitis AM1:  Austin model 1 CAS:  Chemical abstracts

Genome-wide association study of 12 agronomic traits in peach

• Google ScholarSearch for Xiaoli Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhixi Tian in:Nature Research journals • PubMed • Google ScholarSearch for Lirong Wang in:Nature ... no competing financial interests. Corresponding authors Correspondence to Zhixi Tian or Lirong Wang. Supplementary information PDF files1.Supplementary Information Supplementary Figures 1 - 24

An automated framework for 3D serous pigment epithelium detachment segmentation in SD-OCT images

equally to this work. AffiliationsSchool of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, ChinaZhuli Sun, Fei Shi, Lirong Wang, Weifang Zhu, Dehui Xiang & Xinjian ... • Google ScholarSearch for Fei Shi in:Nature Research journals • PubMed • Google ScholarSearch for Lirong Wang in:Nature Research journals • PubMed • Google ScholarSearch for Weifang Zhu in:Nature Research

Automatic Three-dimensional Detection of Photoreceptor Ellipsoid Zone Disruption Caused by Trauma in the OCT

Detection and assessment of the integrity of the photoreceptor ellipsoid zone (EZ) are important because it is critical for visual acuity in retina trauma and other diseases. We have proposed and validated a framework that can automatically analyse the 3D integrity of the EZ in optical coherence tomography (OCT) images. The images are first filtered and automatically segmented...

Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells

Background Hsp90 proteins are important therapeutic targets for many anti-cancer drugs in clinical trials. Geldanamycin (GA) was identified as the first natural inhibitor of Hsp90, increasing evidence suggests that GA was not a good choice for clinical trials. In this study, we investigated two new non-benzoquinone geldanamycin analogs of Hsp90 inhibitors, DHQ3 and 17-demethoxy...

Long-Term Effects of Methadone Maintenance Treatment with Different Psychosocial Intervention Models

This study evaluated the long-term effects of different psychosocial intervention models in methadone maintenance treatment (MMT) in Xi'an China. Patients from five MMT clinics were divided into three groups receiving MMT only, MMT with counseling psychology (CP) or MMT with contingency management (CM). A five-year follow-up was carried out with daily records of medication...

Knowledge of HIV and Willingness to Conduct Oral Rapid HIV Testing among Dentists in Xi’an China

Introduction China is considered a country of low HIV prevalence (780,000 people living with HIV), however, HIV infections among high-risk populations continue to grow at alarming rates. Voluntary Counseling and Testing services were first implemented in 2003, and oral rapid HIV testing (ORHT) began in 2012. Dentists, as oral health experts, would be well placed to conduct ORHT...

A Targeted Library Screen Reveals a New Inhibitor Scaffold for Protein Kinase D

Protein kinase D (PKD) has emerged as a potential therapeutic target in multiple pathological conditions, including cancer and heart diseases. Potent and selective small molecule inhibitors of PKD are valuable for dissecting PKD-mediated cellular signaling pathways and for therapeutic application. In this study, we evaluated a targeted library of 235 small organic kinase...

PPSP: prediction of PK-specific phosphorylation site with Bayesian decision theory

Background As a reversible and dynamic post-translational modification (PTM) of proteins, phosphorylation plays essential regulatory roles in a broad spectrum of the biological processes. Although many studies have been contributed on the molecular mechanism of phosphorylation dynamics, the intrinsic feature of substrates specificity is still elusive and remains to be delineated...

Comparative population genomics reveals the domestication history of the peach, Prunus persica, and human influences on perennial fruit crops

Background Recently, many studies utilizing next generation sequencing have investigated plant evolution and domestication in annual crops. Peach, Prunus persica, is a typical perennial fruit crop that has ornamental and edible varieties. Unlike other fruit crops, cultivated peach includes a large number of phenotypes but few polymorphisms. In this study, we explore the genetic...