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36 papers found.
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Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study

Osteoporosis is a metabolic bone disease. The effect of blood metabolites on the development of osteoporosis remains elusive.

Associations Between Biomarkers of Renal Function With Cerebral Microbleeds in Hypertensive Patients

Cerebral microbleeds (CMBs) have been observed in the elderly and have been regarded as a manifestation of small vessel disease (SVD). Cerebral and glomerular SVD may have a common source of pathogenesis because these organs are closely connected through anatomic and hemodynamic similarities. The purpose of this study was to clarify the associations between kidney biomarker...

GPU-Based Block-Wise Nonlocal Means Denoising for 3D Ultrasound Images

2013; Revised 28 July 2013; Accepted 4 September 2013 Academic Editor: Tianye Niu Copyright © 2013 Liu Li et al. This is an open access article distributed under the Creative Commons Attribution

The Correlation of Expression Levels of HIF-1α and HIF-2α in Hepatocellular Carcinoma with Capsular Invasion, Portal Vein Tumor Thrombi and Patients

The roles of hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in the development of hepatocellular carcinoma have not been fully elucidated. Here, we aim to uncover the relationship between the prognosis of hepatocellular carcinoma patients and the expression of hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in tumor tissues.

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents

Dicer participates in heterochromatin formation in fission yeast and plants. However, whether it has a similar role in mammals remains controversial. Here we showed that the human Dicer protein interacts with SIRT7, an NAD+-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm. Dicer knockdown led to an increase of...

Comparison of bioimpedance methods for estimating total body water and intracellular water changes during hemodialysis

Background. The accurate assessment of body fluid volume is important in many clinical situations. Hannan et al. proposed a single-frequency bioimpedance equation (HE) to calculate extracellular water (ECW) and total body water (TBW). There are two equations based on the bioimpedance spectroscopy (BIS) method for the evaluation of body fluid volume: Xitron equations (XE) and body...

Blood Neutrophil to Lymphocyte Ratio as a Predictor of Hypertension

Hypertension is a significant global public health challenge. Low-grade inflammation is known to facilitate the development of essential hypertension and target-organ hypertensive damage. Neutrophil to lymphocyte ratio (NLR) is a simple and reliable indicator of inflammation that may also be useful in the prediction of hypertension.

USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6

The transcription factor NF-κB plays critical roles in many biological processes, especially immunity. The signaling to NF-κB activation is subtly regulated to avoid harmful immune effects. In this report, we identified ubiquitin-specific protease 2 isoform a (USP2a) as a novel negative regulator in Toll-like receptors/IL-1β- and Sendai virus (SeV)-induced NF-κB activation...

Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population

Recent genome-wide association studies (GWAS) have reported multiple risk loci associated with risk of colorectal cancer (CRC), some of which are involved in the transforming growth factor beta (TGFβ) signaling pathway. We systematically examined associations of common genetic variations in the TGFβ signaling pathway and environmental factors with CRC risk using a two-staged case...

‘RNA walk’ a novel approach to study RNA–RNA interactions between a small RNA and its target

In this study we describe a novel method to investigate the RNA–RNA interactions between a small RNA and its target that we termed ‘RNA walk’. The method is based on UV-induced AMT cross-linking in vivo followed by affinity selection of the hybrid molecules and mapping the intermolecular adducts by RT–PCR or real-time PCR. Domains carrying the cross-linked adducts fail to...

miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1

Breast cancer is the leading cause of cancer death among females, with tumor metastasis being primarily responsible for breast cancer-associated mortality. Current literatures have shown that microRNAs (miRNAs) are implicated in tumor metastasis. In this study, we found that the expression of miR-720 was significantly downregulated in primary breast cancer, with greater...

Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis

Recent resting-state functional connectivity magnetic resonance imaging studies have shown significant group differences in several regions and networks between patients with major depressive disorder and healthy controls. The objective of the present study was to investigate the whole-brain resting-state functional connectivity patterns of depressed patients, which can be used...

Incidence and Risk Factors for the Prozone Phenomenon in Serologic Testing for Syphilis in a Large Cohort

Background. The prozone phenomenon is known to be associated with high antibody titers; other associations, such as host factors, have not been elucidated.

Analysis of 3 Algorithms for Syphilis Serodiagnosis and Implications for Clinical Management

Background. Algorithms for the diagnosis of syphilis continue to be a source of great controversy, and numerous test interpretations have perplexed many clinicians.

Management of ErbB2-positive Breast Cancer: Insights from Preclinical and Clinical Studies with Lapatinib

The management of human epidermal growth factor receptor 2-positive (ErbB2+) breast cancer is challenging; patients with ErbB2+ breast tumors have more aggressive disease and a poor prognosis. The increasing incidence of breast cancer in Asia and the limitations of existing treatments pose additional challenges. In this review, we summarize the preclinical and clinical evidence...