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VFDB 2019: a comparative pathogenomic platform with an interactive web interface

The virulence factor database (VFDB, http://www.mgc.ac.cn/VFs/) is devoted to providing the scientific community with a comprehensive warehouse and online platform for deciphering bacterial pathogenesis. The various combinations, organizations and expressions of virulence factors (VFs) are responsible for the diverse clinical symptoms of pathogen infections. Currently, whole...

VFDB 2016: hierarchical and refined dataset for big data analysis—10 years on

The virulence factor database (VFDB, http://www.mgc.ac.cn/VFs/) is dedicated to providing up-to-date knowledge of virulence factors (VFs) of various bacterial pathogens. Since its inception the VFDB has served as a comprehensive repository of bacterial VFs for over a decade. The exponential growth in the amount of biological data is challenging to the current database in regard...

△-Convergence analysis of improved Kuhfittig iterative for asymptotically nonexpansive nonself-mappings in W-hyperbolic spaces

Throughout this paper, we introduce a class of asymptotically nonexpansive nonself-mapping and modify the classical Kuhfittig iteration algorithm in the general setup of hyperbolic space. Also, △-convergence results are obtained under a limit condition. The results presented in the paper extend various results in the existing literature.

Error compensation in high-speed milling of deep cavity dies and molds based on the lengthened shrink-fit holder

BackgroundIn high speed milling of the dies and molds characterized by large-scale and deep cavities with the lengthened shrink-fit holder (LSFH), the machining error caused by the tool deflection is not allowed to be ignored.MethodsThe deformation of the LSFH and cutting tool are predicted, and at the same time the machining error caused by this deformation are predicted too...

Strong convergence theorems of the Halpern-Mann’s mixed iteration for a totally quasi-ϕ-asymptotically nonexpansive nonself multi-valued mapping in Banach spaces

In this paper, we introduce a class of totally quasi-ϕ-asymptotically nonexpansive nonself multi-valued mapping to modify the Halpern-Mann-type iteration algorithm for a totally quasi-ϕ-asymptotically nonexpansive nonself multi-valued mapping, which has the strong convergence under a limit condition only in the framework of Banach spaces. Our results are applied to study the...

Methane Fluxes along a Permafrost Hillslope Gradient in Northcentral China

Soil methane (CH4) uptake and emissions have significant impacts on global climate change. In this study, we focused on CH4 fluxes in a Larix gmelinii forest, the key vegetation type in the permafrost region of the Greater Xing’an Range of northeast China. We studied the relationship between soil CH4 fluxes and slope position during the growing season. The results indicate that...

Numerical Investigation on Jet Impingement Behaviors Affected by a Vertically Rotating Disk Suspended Close to the Surface

Copyright © 2014 Liu Bo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided

Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice

The Cas9/sgRNA of the CRISPR/Cas system has emerged as a robust technology for targeted gene editing in various organisms, including plants, where Cas9/sgRNA-mediated small deletions/insertions at single cleavage sites have been reported in transient and stable transformations, although genetic transmission of edits has been reported only in Arabidopsis and rice. Large...

Spatio-Temporal Patterns in Rhizosphere Oxygen Profiles in the Emergent Plant Species Acorus calamus

Rhizosphere oxygen profiles are the key to understanding the role of wetland plants in ecological remediation. Though in situ determination of the rhizosphere oxygen profiles has been performed occasionally at certain growing stages within days, comprehensive study on individual roots during weeks is still missing. Seedlings of Acorus calamus, a wetland monocot, were cultivated...

Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Gastric Ulcer and Intervention Effects of Corydalis yanhusuo Alkaloid

Metabolomics, the systematic analysis of potential metabolites in a biological specimen, has been increasingly applied to discovering biomarkers, identifying perturbed pathways, measuring therapeutic targets, and discovering new drugs. By analyzing and verifying the significant difference in metabolic profiles and changes of metabolite biomarkers, metabolomics enables us to...

Synchrotron FTIR Microspectroscopy Study of the Striatum in 6-Hydroxydopamine Rat Model of Parkinson's Disease

In the present study, synchrotron-based Fourier transform-infrared (FTIR) microspectroscopy is used to analyze the biochemical composition of the striatal neurons in normal and Parkinson's disease (PD) rat brain tissues. The rat model of Parkinson's disease is established by destroying the nigrostriatal pathway with 6-hydroxydopamine (6-OHDA). The detailed spectral analyses show...

Synchrotron FTIR Microspectroscopy Study of the Striatum in 6-Hydroxydopamine Rat Model of Parkinson's Disease

In the present study, synchrotron-based Fourier transform-infrared (FTIR) microspectroscopy is used to analyze the biochemical composition of the striatal neurons in normal and Parkinson's disease (PD) rat brain tissues. The rat model of Parkinson's disease is established by destroying the nigrostriatal pathway with 6-hydroxydopamine (6-OHDA). The detailed spectral analyses show...

ARDB—Antibiotic Resistance Genes Database

The treatment of infections is increasingly compromised by the ability of bacteria to develop resistance to antibiotics through mutations or through the acquisition of resistance genes. Antibiotic resistance genes also have the potential to be used for bio-terror purposes through genetically modified organisms. In order to facilitate the identification and characterization of...

The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota

Breast-fed infant microbiota is typically rich in bifidobacteria. Herein, major human milk oligosaccharides (HMOS) are assessed for their ability to promote the growth of bifidobacteria and to acidify their environment, key features of prebiotics. During in vitro anaerobic fermentation of infant microbiota, supplementation by HMOS significantly decreased the pH even greater than...

Contrast-enhanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage

The aim of this study was to investigate the clinical significance of real-time gray-scale contrast-enhanced ultrasound (CEUS) through evaluating renal microvascular perfusion in diabetic kidney damage.

Risk Factors for Influenza A(H7N9) Disease in China, a Matched Case Control Study, October 2014 to April 2015

Background. Human infections with avian influenza A(H7N9) virus have been associated with exposure to poultry and live poultry markets (LPMs). We conducted a case-control study to identify additional and more specific risk factors.

The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension

To investigate the changes of insulin resistance and soluble intercellular adhesion molecule-1 (sICAM-1) in normotensive adolescents with a family history of hypertension (FH) and to analyse the related factors. The study included 142 normotensive adolescents aged 13–15 years. On the basis of an FH, the samples were divided into positive FH (FH+ group) and negative FH groups (FH...

Regulation of the Orphan Receptor TR3 Nuclear Functions by c-Jun N Terminal Kinase Phosphorylation

The orphan receptor TR3 functions in the nucleus as a transcription factor to negatively or positively regulate gene expression. c-Jun N-terminal kinase (JNK) phosphorylation plays an important role in modulating the nuclear functions of TR3. Although TR3 is the phosphorylation target of JNK, the regulatory mechanism of JNK on TR3 functions remains to be elucidated. Here we...