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Bilateral thoracic paravertebral block combined with general anesthesia vs. general anesthesia for patients undergoing off-pump coronary artery bypass grafting: a feasibility study

artery bypass grafting: a feasibility study Lixin Sun†1, Qiujie Li†1, Qiang Wang1, Fuguo Ma1, Wei Han2Email authorView ORCID ID profile and Mingshan Wang1 †Contributed equally BMC ... morphine consumption. Additional studies are necessary to examine the potential AEs. Notes Lixin Sun and Qiujie Li contributed equally to this work. Abbreviations AE:  Adverse event ALT:  Alanine

Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC

Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway...

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

Tumor recurrence, the chief reason for poor prognosis of glioma, is largely attributed to glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT). However, the mechanisms among them remain unknown. Here, we determined whether leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve...

Mechanical and Thermal Properties of R-High Density Polyethylene Composites Reinforced with Wheat Straw Particleboard Dust and Basalt Fiber

Tian,1 Lixin Sun,1 Qinglin Wu,3 and Kai Sun1 1College of Mechanical & Electrical Engineering, Shanxi University of Science & Technology, Xi’an 710021, China 2College of Materials Science and Engineering

Mechanical and Thermal Properties of R-High Density Polyethylene Composites Reinforced with Wheat Straw Particleboard Dust and Basalt Fiber

Tian,1 Lixin Sun,1 Qinglin Wu,3 and Kai Sun1 1College of Mechanical & Electrical Engineering, Shanxi University of Science & Technology, Xi’an 710021, China 2College of Materials Science and Engineering

Mechanical and Thermal Properties of R-High Density Polyethylene Composites Reinforced with Wheat Straw Particleboard Dust and Basalt Fiber

Tian,1 Lixin Sun,1 Qinglin Wu,3 and Kai Sun1 1College of Mechanical & Electrical Engineering, Shanxi University of Science & Technology, Xi’an 710021, China 2College of Materials Science and Engineering

Application of GelGreen™ in Cesium Chloride Density Gradients for DNA-Stable Isotope Probing Experiments

In this study, GelGreen™ was investigated as a replacement for SYBR® Safe to stain DNA in cesium chloride (CsCl) density gradients for DNA-stable isotope probing (SIP) experiments. Using environmental DNA, the usage of GelGreen™ was optimized for sensitivity compared to SYBR® Safe, its optimal concentration, detection limit for environmental DNA and its application in...

Smart motion reconstruction system for golf swing: a DBN model based transportable, non-intrusive and inexpensive golf swing capture and reconstruction system

and Communication Engineering, University of Chinese Academy of Sciences. Her current research interests include signal detection and estimation, target tracking and computer vision. Lixin Sun received

Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer

Background Our aim was to investigate the influence of FTS on human cellular and humoral immunity using a randomized controlled clinical study in esophageal cancer patients. Methods Between October 2013 and December 2014, 276 patients with esophageal cancer in our department were enrolled in the study. The patients were randomized into two groups: FTS pathway group and...

Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice

Metabolic homeostasis is critical for all biological processes in the brain. The metabolites are considered the best indicators of cell states and their rapid fluxes are extremely sensitive to cellular changes. While there are a few studies on the metabolomics of Parkinson’s disease, it lacks longitudinal studies of the brain metabolic pathways affected by aging and the disease...

Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease

of Nantong city (MS2015097). The key projects of Changning District of Shanghai Science and Technology Committee (CNKW2014Z05). Author information Author notesXianli Wang, Chuanming Dong & Lixin Sun ... These authors contributed equally to this work. AffiliationsEast Hospital, Tongji University School of Medicine, Shanghai, ChinaXianli Wang, Chuanming Dong, Lixin Sun, Liang Zhu, Chenxi Sun, Rongjie Ma

Optogenetic Measurement of Presynaptic Calcium Transients Using Conditional Genetically Encoded Calcium Indicator Expression in Dopaminergic Neurons

Calcium triggers dopamine release from presynaptic terminals of midbrain dopaminergic (mDA) neurons in the striatum. However, calcium transients within mDA axons and axon terminals are difficult to study and little is known about how they are regulated. Here we use a newly-developed method to measure presynaptic calcium transients (PreCaTs) in axons and terminals of mDA neurons...

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons

Parkinson's disease (PD), the most common degenerative movement disorder, is caused by a preferential loss of midbrain dopaminergic (mDA) neurons. Both α-synuclein (α-syn) missense and multiplication mutations have been linked to PD. However, the underlying intracellular signalling transduction pathways of α-syn-mediated mDA neurodegeneration remain elusive. Here, we show that...

Corrigendum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Loukia Parisiadou, Jia Yu, Carmelo Sgobio, Chengsong Xie, Guoxiang Liu, Lixin Sun, Xing-Long Gu, Xian Lin, Nicole A Crowley, David M Lovinger & Huaibin Cai Nat. Neurosci. Corrigendum: Post-study

Corrigendum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Loukia Parisiadou, Jia Yu, Carmelo Sgobio, Chengsong Xie, Guoxiang Liu, Lixin Sun, Xing-Long Gu, Xian Lin, Nicole A Crowley, David M Lovinger & Huaibin Cai Nat. Neurosci. Corrigendum: Post-study

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons

Jia Yu Nikolai Chub Hoon Shim Lixin Sun Chengsong Xie Wan-Jou Yang Xian Lin Michael J. O'Donovan Huaibin Cai 0 The Author 2014. Published by Oxford University Press. All rights reserved We have

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons

The substitution of Proline with Serine at residue 56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) has been linked to an atypical autosomal dominant form of familial amyotrophic lateral sclerosis 8 (ALS8). To investigate the pathogenic mechanism of P56S VAPB in ALS, we generated transgenic (Tg) mice that heterologously express human wild-type (WT) and...

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

Background Parkinson's disease (PD) is the most common movement disorder. While neuronal deposition of α-synuclein serves as a pathological hallmark of PD and Dementia with Lewy Bodies, α-synuclein-positive protein aggregates are also present in astrocytes. The pathological consequence of astrocytic accumulation of α-synuclein, however, is unclear. Results Here we show that PD...

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein

Recent genome-wide association studies indicate that a simple alteration of Leucine-rich repeat kinase 2 (LRRK2) gene expression may contribute to the etiology of sporadic Parkinson's disease (PD). However, the expression and regulation of LRRK2 protein in the sporadic PD brains remain to be determined. Here, we found that the expression of LRRK2 protein was enhanced in the...