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Characterization of Chinese Haemophilus parasuis Isolates by Traditional Serotyping and Molecular Serotyping Methods

Haemophilus parasuis is classified mainly through serotyping, but traditional serotyping always yields non-typable (NT) strains and unreliable results via cross-reactions. Here, we surveyed the serotype prevalence of Chinese H. parasuis isolates using traditional serotyping (gel immuno-diffusion test, GID) and molecular serotyping (multiplex PCR, mPCR). We also investigated why...

Changing trend of HIV, Syphilis and Hepatitis C among Men Who Have Sex with Men in China

Dearth of information regarding the trend and correlates of HIV, syphilis and Hepatitis C (HCV) in a country-wide sample of understudied though high-risk Chinese men who have sex with men (MSM) called for a comprehensive serial cross-sectional study. Using a multistage mixed-method strategy, 171,311 MSM from 107 selected cities/counties in 30 provinces of mainland China, were...

G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice

Granulocyte colony-stimulating factor (G-CSF) was investigated for its capacity to induce autophagy and related neuroprotective mechanisms in an acute spinal cord injury model. To accomplish this goal, we established a mouse spinal cord hemisection model to test the effects of recombinant human G-CSF. The results showed that autophagy was activated after spinal cord injury and G...

FAT10 is associated with the malignancy and drug resistance of non-small cell lung cancer

FAT10 is associated with the malignancy and drug resistance of non-small cell lung cancer Feng Xue,1,2,* Lin Zhu,3,* Qing-wei Meng,1 Liyan Wang,2 Xue-song Chen,1 Yan-bin Zhao,1 Ying Xing,1 Xiao-yun

Biological effects and mechanisms of action of mesenchymal stem cell therapy in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is the most frequent chronic respiratory disease and a leading cause of morbidity and mortality, worldwide. Given that the foremost risk factor leading to the development of COPD is cigarette smoke, the initial treatment for COPD is smoking cessation. Even after smoking cessation, inflammation, apoptosis and oxidative stress can...

Purified hepatitis B virus induces human Mesangial cell proliferation and extracellular matrix expression In Vitro

Background Hepatitis B virus (HBV) induces proliferation of human mesangial cells (HMCs), and extracellular matrix expression through the deposition of immune complexes in renal tissue. However, it is unclear whether HBV can directly affect HMCs. In this study, the effects of purified HBV on HMC proliferation and extracellular matrix expression in vitro was determined. Findings...

Mortality among People Living with HIV and AIDS in China: Implications for Enhancing Linkage

, Beijing, ChinaMeng Li, Kai Bu, Xiayan Zhang, Yibing Feng, Fangfang Chen, Wei Guo, Liyan Wang, Zhengwei Ding, Qianqian Qin, Shiliang Liu, Lu Wang & Ning WangUniversity of North Carolina Project-China ... • PubMed • Google ScholarSearch for Wei Guo in:Nature Research journals • PubMed • Google ScholarSearch for Liyan Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhengwei Ding in:Nature

Causes of Death among AIDS Patients after Introduction of Free Combination Antiretroviral Therapy (cART) in Three Chinese Provinces, 2010–2011

Introduction Although AIDS-related deaths have had significant economic and social impact following an increased disease burden internationally, few studies have evaluated the cause of AIDS-related deaths among patients with AIDS on combination anti-retroviral therapy (cART) in China. This study examines the causes of death among AIDS-patients in China and uses a methodology to...

Spatial Analysis on Hepatitis C Virus Infection in Mainland China: From 2005 to 2011

and designed the experiments: Lu Wang JX. Performed the experiments: Lu Wang JX. Analyzed the data: Lu Wang JX. Contributed reagents/materials/analysis tools: Lu Wang JX RY LG QQ Liyan Wang ZD WG NW

Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice

Here, we investigated the impact of mulberry fruit (MBF) extracts on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages, and the therapeutic efficacy of MBF diet in mice with dextran sulfate sodium (DSS)-induced acute colitis and MUC2−/− mice with colorectal cancer. In vitro, LPS-induced nitric oxide (NO) production was significantly inhibited by MBF...

Baseline CD4 Cell Counts of Newly Diagnosed HIV Cases in China: 2006–2012

Background Late diagnosis of HIV infection is common. We aim to assess the proportion of newly diagnosed HIV cases receiving timely baseline CD4 count testing and the associated factors in China. Methods Data were extracted from the Chinese HIV/AIDS Comprehensive Response Information Management System. Adult patients over 15 years old who had been newly diagnosed with HIV...

HIV/AIDS Epidemic Among Older Adults in China During 2005–2012: Results From Trend and Spatial Analysis

Background. Recent studies have indicated an increasing burden of human immunodeficiency virus (HIV)/AIDS among older adults. Methods. All identified people living with HIV/AIDS (PLWHA) recorded through the Chinese HIV/AIDS CRS during 2005–2012 were included in the study, except for the cases that lacked specific spatial information. Trend tests and spatial analyses were...