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23 papers found.
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A Cornea Substitute Derived from Fish Scale: 6-Month Followup on Rabbit Model

A fish scale-derived cornea substitute (Biocornea) is proposed as an alternative for human donor corneal tissue. We adopt a regenerative medicine approach to design a primary alternative to the use of fish scale for restoring sight by corneal replacement. Biocornea with corneal multilayer arrangement collagen was implanted to rabbits by pocket implantation. Our study demonstrated...

A Viral Product Diffusion Model to Forecast the Market Performance of Products

To investigate the diffusion of products in the market, this paper proposes a viral product diffusion model using an epidemiological approach. This model presents the process of product diffusion through the dynamics of human behaviors. Based on the stability theory of Ordinary Differential Equations, we demonstrate the conditions under which a product in the market persists or...

A Viral Product Diffusion Model to Forecast the Market Performance of Products

To investigate the diffusion of products in the market, this paper proposes a viral product diffusion model using an epidemiological approach. This model presents the process of product diffusion through the dynamics of human behaviors. Based on the stability theory of Ordinary Differential Equations, we demonstrate the conditions under which a product in the market persists or...

Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis

Research Program of China (973 Program, 2012CB124701) and Shenzhen overseas high-level talents innovation program No.YFZZ20111009 (to D.G.). Author information Author notesLi Li, Liyan Wang & Zhiqin Wu ... synthetic biology, Shenzhen University, Shenzhen 518060, ChinaKan Liu AuthorsSearch for Li Li in:Nature Research journals • PubMed • Google ScholarSearch for Liyan Wang in:Nature Research journals • PubMed

Baseline CD4 Cell Counts of Newly Diagnosed HIV Cases in China: 2006–2012

Background Late diagnosis of HIV infection is common. We aim to assess the proportion of newly diagnosed HIV cases receiving timely baseline CD4 count testing and the associated factors in China. Methods Data were extracted from the Chinese HIV/AIDS Comprehensive Response Information Management System. Adult patients over 15 years old who had been newly diagnosed with HIV...

Biological effects and mechanisms of action of mesenchymal stem cell therapy in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is the most frequent chronic respiratory disease and a leading cause of morbidity and mortality, worldwide. Given that the foremost risk factor leading to the development of COPD is cigarette smoke, the initial treatment for COPD is smoking cessation. Even after smoking cessation, inflammation, apoptosis and oxidative stress can...

Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis

Complement represents a chief component of innate immunity in host defense. However, excessive complement activation has been involved in the pathogenesis of inflammatory diseases. In this study, we investigated the contribution of complement to intestinal pathology of patients and rodents with inflammatory bowel disease. The expression of complement effectors (C3a and C3) was...

Causes of Death among AIDS Patients after Introduction of Free Combination Antiretroviral Therapy (cART) in Three Chinese Provinces, 2010–2011

Introduction Although AIDS-related deaths have had significant economic and social impact following an increased disease burden internationally, few studies have evaluated the cause of AIDS-related deaths among patients with AIDS on combination anti-retroviral therapy (cART) in China. This study examines the causes of death among AIDS-patients in China and uses a methodology to...

Changing trend of HIV, Syphilis and Hepatitis C among Men Who Have Sex with Men in China

Dearth of information regarding the trend and correlates of HIV, syphilis and Hepatitis C (HCV) in a country-wide sample of understudied though high-risk Chinese men who have sex with men (MSM) called for a comprehensive serial cross-sectional study. Using a multistage mixed-method strategy, 171,311 MSM from 107 selected cities/counties in 30 provinces of mainland China, were...

Characterization of Chinese Haemophilus parasuis Isolates by Traditional Serotyping and Molecular Serotyping Methods

Haemophilus parasuis is classified mainly through serotyping, but traditional serotyping always yields non-typable (NT) strains and unreliable results via cross-reactions. Here, we surveyed the serotype prevalence of Chinese H. parasuis isolates using traditional serotyping (gel immuno-diffusion test, GID) and molecular serotyping (multiplex PCR, mPCR). We also investigated why...

Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis

TNF-related apoptosis-inducing ligand (TRAIL) is a TNF family member capable of inducing apoptosis. Death receptor 5 (DR 5) is a key receptor of TRAIL and plays an important role in TRAIL-induced apoptosis. To prepare monoclonal antibodies (mAbs) against DR5, cDNA encoding soluble DR5 (sDR5) was firstly amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) with...

FAT10 is associated with the malignancy and drug resistance of non-small cell lung cancer

FAT10 is associated with the malignancy and drug resistance of non-small cell lung cancer Feng Xue,1,2,* Lin Zhu,3,* Qing-wei Meng,1 Liyan Wang,2 Xue-song Chen,1 Yan-bin Zhao,1 Ying Xing,1 Xiao-yun

G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice

Granulocyte colony-stimulating factor (G-CSF) was investigated for its capacity to induce autophagy and related neuroprotective mechanisms in an acute spinal cord injury model. To accomplish this goal, we established a mouse spinal cord hemisection model to test the effects of recombinant human G-CSF. The results showed that autophagy was activated after spinal cord injury and G...

HIV/AIDS Epidemic Among Older Adults in China During 2005–2012: Results From Trend and Spatial Analysis

Background. Recent studies have indicated an increasing burden of human immunodeficiency virus (HIV)/AIDS among older adults. Methods. All identified people living with HIV/AIDS (PLWHA) recorded through the Chinese HIV/AIDS CRS during 2005–2012 were included in the study, except for the cases that lacked specific spatial information. Trend tests and spatial analyses were...

Improved Robust Stability Criterion of Networked Control Systems with Transmission Delays and Packet Loss

The problem of stability analysis for a class of networked control systems (NCSs) with network-induced delay and packet dropout is investigated in this paper. Based on the working mechanism of zero-order holder, the closed-loop NCS is modeled as a continuous-time linear system with input delay. By introducing a novel Lyapunov-Krasovskii functional which splits both the lower and...

Mortality among People Living with HIV and AIDS in China: Implications for Enhancing Linkage

, Beijing, ChinaMeng Li, Kai Bu, Xiayan Zhang, Yibing Feng, Fangfang Chen, Wei Guo, Liyan Wang, Zhengwei Ding, Qianqian Qin, Shiliang Liu, Lu Wang & Ning WangUniversity of North Carolina Project-China ... • PubMed • Google ScholarSearch for Wei Guo in:Nature Research journals • PubMed • Google ScholarSearch for Liyan Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhengwei Ding in:Nature

Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice

Here, we investigated the impact of mulberry fruit (MBF) extracts on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages, and the therapeutic efficacy of MBF diet in mice with dextran sulfate sodium (DSS)-induced acute colitis and MUC2−/− mice with colorectal cancer. In vitro, LPS-induced nitric oxide (NO) production was significantly inhibited by MBF...

Purified hepatitis B virus induces human Mesangial cell proliferation and extracellular matrix expression In Vitro

Background Hepatitis B virus (HBV) induces proliferation of human mesangial cells (HMCs), and extracellular matrix expression through the deposition of immune complexes in renal tissue. However, it is unclear whether HBV can directly affect HMCs. In this study, the effects of purified HBV on HMC proliferation and extracellular matrix expression in vitro was determined. Findings...

Robust Filtering for Networked Control Systems with Random Sensor Delay

The robust filtering problem for a class of network-based systems with random sensor delay is investigated. The sensor delay is supposed to be a stochastic variable satisfying Bernoulli binary distribution. Using the Lyapunov function and Wirtinger’s inequality approach, the sufficient conditions are derived to ensure that the filtering error systems are exponentially stable with...

Robust Filtering for Networked Control Systems with Random Sensor Delay

The robust filtering problem for a class of network-based systems with random sensor delay is investigated. The sensor delay is supposed to be a stochastic variable satisfying Bernoulli binary distribution. Using the Lyapunov function and Wirtinger’s inequality approach, the sufficient conditions are derived to ensure that the filtering error systems are exponentially stable with...