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A Knowledge Generation Model via the Hypernetwork

The influence of the statistical properties of the network on the knowledge diffusion has been extensively studied. However, the structure evolution and the knowledge generation processes are always integrated simultaneously. By introducing the Cobb-Douglas production function and treating the knowledge growth as a cooperative production of knowledge, in this paper, we present...

A common set of distinct features that characterize noncoding RNAs across multiple species

To find signature features shared by various ncRNA sub-types and characterize novel ncRNAs, we have developed a method, RNAfeature, to investigate >600 sets of genomic and epigenomic data with various evolutionary and biophysical scores. RNAfeature utilizes a fine-tuned intra-species wrapper algorithm that is followed by a novel feature selection strategy across species. It...

ANGIOGENESIS AND INVASION

MEDIATOR OF GROWTH DURING ANTIANGIOGENIC THERAPY IN GLIOBLASTOMA Samuel D. Rose, W. Shawn Carbonell, Michael De Lay, Yu-Long Hu, Jesse Paquette, Taku Tokuyasu, Sean Tsao, Myriam Chaumeil, Sabrina Ronen, and ... ANTIANGIOGENIC TREATMENT IN GLIOBLASTOMA Yu-Long Hu, Michael De Lay, Samuel D. Rose, W. Shawn Carbonell, and Manish K. Aghi; University of California, San Francisco , San Francisco, CA 5 AI-04. HUMAN

Adjuvant Chinese Herbal Products for Preventing Ischemic Stroke in Patients with Atrial Fibrillation

Objective Chinese herbal products (CHPs) are widely used for atrial fibrillation (AF) in Taiwan. We investigated the effect of adjuvant CHPs in preventing ischemic stroke in patients with AF. Methods Taiwanese patients in the Health Insurance Database newly diagnosed with AF during 2000–2011 were enrolled. Medication treatment with/without CHPs was administered within 7 days...

COME: a robust coding potential calculation tool for lncRNA identification and characterization based on multiple features

Recent genomic studies suggest that novel long non-coding RNAs (lncRNAs) are specifically expressed and far outnumber annotated lncRNA sequences. To identify and characterize novel lncRNAs in RNA sequencing data from new samples, we have developed COME, a coding potential calculation tool based on multiple features. It integrates multiple sequence-derived and experiment-based...

Comparative analysis of the transcriptome across distant species

Guanjun Gao Peter J. Good Roderic Guig o? Ann Hammonds Jen Harrow Roger A. Hoskins Ce?dric Howald Long Hu Haiyan Huang Tim J. P. Hubbard Chau Huynh Sonali Jha Dionna Kasper Masaomi Kato Thomas C. Kaufman

Cyproheptadine Enhances the IK of Mouse Cortical Neurons through Sigma-1 Receptor-Mediated Intracellular Signal Pathway

Cyproheptadine (CPH) is a histamine- and serotonin-receptor antagonist, and its effects are observed recently in the modulation of multiple intracellular signals. In this study, we used cortical neurons and HEK-293 cells transfected with Kv2.1 α-subunit to address whether CPH modify neural voltage-gated K+ channels by a mechanism independent of its serotonergic and histaminergic...

Demographic and Prescribing Patterns of Chinese Herbal Products for Individualized Therapy for Ischemic Heart Disease in Taiwan: Population-Based Study

Objective Combinations of Chinese herbal products (CHPs) are widely used for ischemic heart disease (IHD) in Taiwan. We analyzed the usage and frequency of CHPs prescribed for patients with IHD. Methods A nationwide population-based cross-sectional study was conducted, 53531 patients from a random sample of one million in the National Health Insurance Research Database (NHIRD...

Dual Mechanisms for Lysophosphatidic Acid Stimulation of Human Ovarian Carcinoma Cells

Background: Lysophosphatidic acid (LPA), at concentrations present in ascitic fluid, indirectly stimulates the growth of malignant ovarian tumors by increasing the expression of vascular endothelial growth factor (VEGF) in ovarian cancer cells. We investigated whether LPA could also directly promote ovarian tumor growth by increasing the level of cyclin D1, a key G1-phase...

Effect of cooling rate on the crystallization behavior of perovskite in high titanium-bearing blast furnace slag

involved in the formation of perovskite. Corresponding author: Mei-long Hu E-mail: University of Science and Technology Beijing and Springer-Verlag Berlin Heidelberg 2014 blast furnace slag; perovskite

Fabrication and characterization of GaN-based light-emitting diodes without pre-activation of p-type GaN

We fabricated GaN-based light-emitting diodes (LEDs) without pre-activation of p-type GaN. During the fabrication process, a 100-nm-thick indium tin oxide film was served as the p-type contact layer and annealed at 500°C in N2 ambient for 20 min to increase its transparency as well as to activate the p-type GaN. The electrical measurements showed that the LEDs were featured by a...

Fabrication and in vitro biological properties of piezoelectric bioceramics for bone regeneration

information AffiliationsDepartment of Materials Science and Engineering, Xi’an University of Technology, Xi’an 710048, PR ChinaYufei Tang, Cong Wu, Long Hu & Kang ZhaoInstitute of Orthopaedics, Xi’jing Hospital ... Research journals • PubMed • Google ScholarSearch for Zixiang Wu in:Nature Research journals • PubMed • Google ScholarSearch for Long Hu in:Nature Research journals • PubMed • Google ScholarSearch for Wei

Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies

Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at...

HOXA9 regulates miR-155 in hematopoietic cells

HOXA9-mediated up-regulation of miR-155 was noted during an array-based analysis of microRNA expression in Hoxa9−/−bone marrow (BM) cells. HOXA9 induction of miR-155 was confirmed in these samples, as well as in wild-type versus Hoxa9-deficient marrow, using northern analysis and qRT–PCR. Infection of wild-type BM with HOXA9 expressing or GFP+ control virus further confirmed...

Laser Acupuncture Therapy in Patients with Treatment-Resistant Temporomandibular Disorders

Objective To investigate the clinical effects of laser acupuncture therapy for temporomandibular disorders (TMD) after ineffective previous treatments. Methods A retrospective observational study was conducted in 29 treatment-resistant TMD patients (25 women, 4 men; age range, 17–67 years). Subjects were treated 3 times per week for 4 weeks with the Handylaser Trion (GaAlAs laser...

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

Background: Lysophosphatidic acid (LPA) stimulates ovarian tumor growth at concentrations present in ascitic fluid. Vascular endothelial growth factor (VEGF) stimulates angiogenesis and plays a pivotal role in the formation of ovarian cancer-associated ascites. We examined whether LPA promotes ovarian tumor growth by increasing angiogenesis via VEGF. Methods: VEGF expression was...

Measurement-device-independent quantum key distribution via quantum blockade

-Bin Wang proposed this work, Zong-Wen Yu and Yi-Heng Zhou studied the QKD part, Ao Li studied the quantum blockade part. Xiao-Long Hu and Cong Jiang did the calculations and drew the figures. Zong-Wen