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Experimental Study on Impermeability of Recycled Concrete

Recycled concrete is a kind of concrete which is constructed by crushing and removing the building waste and concrete blocks and mixing them according to a certain proportion after grading. In this study, the applicability of recycled concrete is studied only in terms of impermeability.

Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3′UTR lengths, production of which is influenced by cellular conditions. Here, we show that arsenic stress elicits global shortening of 3′UTRs through preferential usage of proximal polyadenylation sites during stress and enhanced degradation of long 3′UTR isoforms during recovery. We...

Operando and three-dimensional visualization of anion depletion and lithium growth by stimulated Raman scattering microscopy

Visualization of ion transport in electrolytes provides fundamental understandings of electrolyte dynamics and electrolyte-electrode interactions. However, this is challenging because existing techniques are hard to capture low ionic concentrations and fast electrolyte dynamics. Here we show that stimulated Raman scattering microscopy offers required resolutions to address a long...

MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5

MicroRNA-106a-5p (MiR-106a-5p), a small non-coding RNA, has been reported to be downregulated in astrocytoma, osteosarcoma and colorectal cancer. However, the expression levels and biological function in renal cell carcinoma (RCC) have not been studied yet. In this study, we found that the miR-106a-5p was significantly downregulated in RCC tissues and cell lines, and that...

PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo

Abnormal proliferation is significantly associated with the promotion of malignant tumor. Growing evidence suggest that the signal pathways of p21cdc42/rac1-activated kinase 5 (PAK5) have been found in various tumor progression, however, the role of PAK5 in breast cancer remains largely unclear. We evaluated PAK5 and p65 staining in breast cancer tissues (BCTs) and paired non...

Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering

acknowledges support from a National Science Foundation Graduate Research Fellowship. Author information AffiliationsDepartment of Chemistry, Columbia University, New York, New York, USAFanghao Hu, Lu Wei ... , USAWei Min AuthorsSearch for Fanghao Hu in:Nature Research journals • PubMed • Google ScholarSearch for Michael R. Lamprecht in:Nature Research journals • PubMed • Google ScholarSearch for Lu Wei in:Nature

Identification of hub miRNA biomarkers for bladder cancer by weighted gene coexpression network analysis

Identification of hub miRNA biomarkers for bladder cancer by weighted gene coexpression network analysis Feng Zhao,1,* Yu-Zheng Ge,1,* Liu-Hua Zhou,1 Lu-Wei Xu,1 Zheng Xu,1 Wen-Wen Ping,2 Min Wang,1

Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt

work. AffiliationsDepartment of Pathology, Xuzhou Medical University, Xuzhou, 221004, ChinaLu-Lu Wei & Dong-Sheng PeiDepartment of Physiology, Xuzhou Medical University, Xuzhou, 221004, ChinaJin-Xia ... Du in:Nature Research journals • PubMed • Google Scholar Search for Xiu-Cun Wang in:Nature Research journals • PubMed • Google Scholar Search for Lu-Lu Wei in:Nature Research journals • PubMed

A new model mimicking persistent HBV e antigen-negative infection using covalently closed circular DNA in immunocompetent mice

Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem. HBV e antigen (HBeAg)-negative strains have become prevalent. Previously, no animal model mimicked the clinical course of HBeAg-negative HBV infection. To establish an HBeAg-negative HBV infection model, the 3.2-kb full-length genome of HBeAg-negative HBV was cloned...

A novel suspension-floating-circulating fluidized combustion technology for coal slurry

A novel suspension-floating-circulating fluidized combustion technology is proposed for burning coal slurry fuel in traditional circulating fluidized bed boilers (CFBB). This technology can solve some existing problems in large-capacity CFBB burning coal slurry. The principles of the suspension-floating-circulating fluidized combustion technology were introduced in detail in this...

Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle

Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that the differential activation of NF-κB subunits confer the opposite effect of NKRF...

Short-Term Surveillance of Cytokines and C-Reactive Protein Cannot Predict Efficacy of Fecal Microbiota Transplantation for Ulcerative Colitis

Objective There were no reports on predicting long-term efficacy of fecal microbiota transplantation (FMT) for ulcerative colitis (UC). This study aimed to detect short-term changes of cytokines and C-reactive protein (CRP) in patients with UC undergoing FMT, and to evaluate the predictive value of CRP and cytokines for the long-term efficacy of FMT. Methods Nineteen patients...

Optimality Conditions for ε-Vector Equilibrium Problems

: Guanglu Zhou Copyright © 2014 Lu Wei-zhong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Optimality Conditions for ε-Vector Equilibrium Problems

: Guanglu Zhou Copyright © 2014 Lu Wei-zhong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese Xiaoshuang Ye,1 Lu Wei,1 Xiaohua Pei,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1

The indirect microscopic observation drug susceptibility assay demonstrated high concordance with the indirect MGIT method for pyrazinamide susceptibility testing

The microscopic observation drug susceptibility (MODS) assay has been used for Mycobacterium tuberculosis detection and anti-TB drug susceptibility tests for several years, and our study aimed to evaluate the accuracy of MODS in detecting pyrazinamide resistance in MDR TB suspects.

Reference Intervals for Serum Cystatin C and Factors Influencing Cystatin C Levels Other than Renal Function in the Elderly

Objective The present study aimed to establish reference intervals for serum cystatin C (Scys-C) stratified by stages of chronic kidney disease, explore factors influencing Scys-C and compare the performance of Scys-C with serum creatinine (Scr) in the young and elderly. Methods A total of 800 participants, 516 young (<60 years) and 284 old (≥60 years) subjects were included in...

Comparisons between the 2012 New CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) Equations and Other Four Approved Equations

Objective The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) reported two equations in 2012: one based on cystatin C concentration (CKD-EPI2012cys) and the other using both serum creatinine and cystatin C concentrations (CKD-EPI2012Scr-cys). We compared the adaptability of new formulae with other four equations. Methods Participants (n = 788; median age, 54 [range...