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Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle

(2018GJ007). Author Contributions Conceptualization: Weixiu Ji, Siwang Yu, Ying Zhang. Data curation: Weixiu Ji, Linjia Wang, Shiyi He, Lu Yan, Tieying Li. Funding acquisition: Ying Zhang. Investigation ... : Weixiu Ji, Linjia Wang, Shiyi He, Lu Yan, Tieying Li. Methodology: Weixiu Ji. Project administration: Ying Zhang. Resources: Ying Zhang. Supervision: Siwang Yu, Ying Zhang. Visualization: Weixiu Ji

Structural variation during dog domestication: insights from gray wolf and dhole genomes

Several processes like phenotypic evolution, disease susceptibility and environmental adaptations, which fashion the domestication of animals, are largely attributable to structural variations (SVs) in the genome. Here, we present high-quality draft genomes of the gray wolf (Canis lupus) and dhole (Cuon alpinus) with scaffold N50 of 6.04 Mb and 3.96 Mb, respectively. Sequence...

Strategies to enhance the production of pinoresinol and its glucosides by endophytic fungus (Phomopsis sp. XP-8) isolated from Tu-chung bark

To improve the production yield of (+)-pinoresinol (Pin), (+)-pinoresinol monoglucoside (PMG), and (+)-pinoresinol diglucoside (PDG), different methods were conducted, including co-culture with resveratrol-producing Alternaria sp. MG1 spores and addition of Tu-chung in a medium at the start of cultivation, ultrasound treatment (40 kHZ, 10 min) on 5-day culture, and addition of...

Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells

The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon adenocarcinoma. In this study, the potential of B. subtilis lipopeptides (a mixture of iturin homologues, concentration of 42.75%) to inhibit chronic myelogenous leukemia was evaluated using K562 myelogenous...

Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant

Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant Ji-Hui Zhao,1,* Qi-Bo Zhang,1,* Bao Liu,2 Xiang-Hua Piao,1 Yu-Lu Yan,1

Oleoylethanolamide exerts anti-inflammatory effects on LPS-induced THP-1 cells by enhancing PPARα signaling and inhibiting the NF-κB and ERK1/2/AP-1/STAT3 pathways

Yang, Han Guo, Xianglan Meng, Lu Yan, Hao Zhou, Lu Peng & Xin JinDepartment of Pharmacology, Xiamen Medical College, Xiamen, Fujian, 361008, P. R. ChinaYing LiDepartment of Cardiology, the First ... ScholarSearch for Ying Li in:Nature Research journals • PubMed • Google ScholarSearch for Xianglan Meng in:Nature Research journals • PubMed • Google ScholarSearch for Lu Yan in:Nature Research journals • PubMed

Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer

Background TRIM62 (tripartite motif containing 62) has been found to act as a tumor suppressor of several cancers. However, its precise biological role and related mechanism remain unknown in cervical cancer (CC). Methods Quantitative Real-time PCR and western blot were adopted to detect the mRNA and protein expression level of TRIM62 in both human CC cell lines and tissues...

Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma

Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. Therefore, we explored circulating tumor cells’ distribution in nasopharyngeal carcinoma and...

Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling

. Author information AffiliationsDivision of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, ChinaJian-Shu Lou, Lu Yan, Cathy W. C ... • Google ScholarSearch for Lu Yan in:Nature Research journals • PubMed • Google ScholarSearch for Cathy W. C. Bi in:Nature Research journals • PubMed • Google ScholarSearch for Gallant K. L. Chan in:Nature

Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line

Background Gastric cancer (GC) is a threat to human health with increasing incidence and mortality worldwide. Down-regulation or absence of RAF kinase inhibitor protein (RKIP) was associated with the occurrence, differentiation, invasion, and metastasis of GC. This study aims to investigate the molecular mechanisms and biological functions of RKIP in the GC biology. Methods The...

Human CD133-positive hematopoietic progenitor cells initiate growth and metastasis of colorectal cancer cells

The tumour-specific ‘pre-metastatic niche’ has emerged as a potential driving force for tumour metastasis and has been confirmed using mouse models of cancer metastasis. Vascular endothelial growth factor receptor-1+ hematopoietic progenitor cells (HPCs) have been shown to play an important role in metastasis, forming a ‘pre-metastatic niche’ at designated sites for distant...

Cytotoxicity and genotoxicity of multi-walled carbon nanotubes with human ocular cells

Cytotoxicity and genotoxicity of plasma-modified multi-walled carbon nanotubes (MWCNTs), including hydroxyl-MWCNTs (MWCNT-OH), carboxyl-MWCNTs (MWCNT-COOH) and pristine MWCNTs, with human ocular cells (e.g. retinal pigment epithelium (RPE) cells) have been studied in this work. The addition of MWCNT-based materials caused few change in cell morphology while the presence of MWCNTs...

Auto- and Cross-repression of Three Arabidopsis WRKY Transcription Factors WRKY18, WRKY40, and WRKY60 Negatively Involved in ABA Signaling

Some members of the WRKY transcription factor family are known to be involved in ABA signaling. However, it remains unclear how the WRKY transcription factors cooperate to regulate ABA signaling. In the present study, we showed that three Arabidopsis (A. thaliana) WRKY proteins previously identified as ABA signaling regulators, WRKY18, WRKY40, and WRKY60, directly target the W...

DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale

We present a method and web server for predicting DNA structural features in a high-throughput (HT) manner for massive sequence data. This approach provides the framework for the integration of DNA sequence and shape analyses in genome-wide studies. The HT methodology uses a sliding-window approach to mine DNA structural information obtained from Monte Carlo simulations. It...

The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma

Academic Editor: T. Nakayama Copyright © 2012 Lu Yan-ming et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution ... Mite-Sensitized Children with Asthma Lu Yan-ming, Cao Lan-fang, Li Chen, Li Ya-qin, Chen Wei, and Zhang Wen-ming Department of Pediatrics, Renji Hospital, Shanghai Jiaotong University School of Medicine

The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma

Academic Editor: T. Nakayama Copyright © 2012 Lu Yan-ming et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution

Deregulated HOXB7 Expression Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma and Regulates Cancer Cell Proliferation In Vitro and In Vivo

Background We observed abnormal HOXB7 expression in esophageal squamous cell carcinoma (ESCC) previously. This study was to evaluate the prognostic significance of HOXB7 and reveal the potential mechanism. Methods Immunohistochemistry was used to confirm the abnormal expression of HOXB7 in ESCC. The prognostic significance of HOXB7 expression was analyzed in two independent...

Electroacupuncture improves orthostatic tolerance in healthy individuals via improving cardiac function and activating the sympathetic system

Orthostatic intolerance (OI) is a common clinical problem; however, effective and applicable clinical prevention/treatment is limited. The aim of this study was to investigate whether electroacupuncture (EA) is a novel effective treatment in attenuating OI in healthy individuals.