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Bio-inspired low-tortuosity carbon host for high-performance lithium-metal anode

Lithium metal is one of the most promising anode materials for high-energy-density Li batteries. However, low stability caused by dendrite growth and volume change during cycling hinders its practical application. Herein, we report an ingenious design of bio-inspired low-tortuosity carbon with tunable vertical micro-channels to be used as a host to incorporate nanosized Sn/Ni...

Prevention of Adolescent Problem Behavior: Longitudinal Impact of the Project P.A.T.H.S. in Hong Kong

The present study attempts to examine the longitudinal impact of a curriculum-based positive youth development program, entitled the Project P.A.T.H.S. (Positive Adolescent Training through Holistic Social Programmes), on adolescent problem behavior in Hong Kong. Using a longitudinal randomized group design, six waves of data were collected from 19 experimental schools (n = 3,797...

Validation of the Simplified Chinese Psychoeducational Profile Third Edition in Mainland China

The Psychoeducational Profile 3rd Edition (PEP-3) is a comprehensive assessment tool designed for children with autism spectrum disorder (ASD). Although its original English version has been validated, few validation studies have been conducted on translated versions including Chinese ones. Based on 554 Chinese children with ASD and 311 typically developing Chinese children as...

Description and molecular analysis of Tylencholaimus helanensis sp. n. from China (Dorylaimida, Tylencholaimidea)

Dong-Wei Wang, Wen-Jia Wu, Lu Yu, and Hui Xie. Female holotype (M51.B.a) and six female paratype specimens (slide numbers: M51.A.a, b, c, d, e and M51.B.b) are deposited in the Lab of Plant Nematology

Hybrid Network-on-Chip: An Application-Aware Framework for Big Data

Burst growing IoT and cloud computing demand exascale computing systems with high performance and low power consumption to process massive amounts of data. Modern system platforms based on fundamental requirements encounter a performance gap in chasing exponential growth in data speed and amount. To narrow the gap, a heterogamous design gives us a hint. A network-on-chip (NoC...

Hybrid Network-on-Chip: An Application-Aware Framework for Big Data

Burst growing IoT and cloud computing demand exascale computing systems with high performance and low power consumption to process massive amounts of data. Modern system platforms based on fundamental requirements encounter a performance gap in chasing exponential growth in data speed and amount. To narrow the gap, a heterogamous design gives us a hint. A network-on-chip (NoC...

BCL3 Expression Is a Potential Prognostic and Predictive Biomarker in Acute Myeloid Leukemia of FAB Subtype M2

Although the implication of BCL3 has been disclosed in human chronic lymphocytic leukemia as well as other solid tumors, the diagnostic and prognostic of BCL3 expression in acute myeloid leukemia (AML) remains largely unclear. In this study, we isolated total RNA from bone marrow mononuclear cells collected from 101 de novo AML patients and 27 healthy donors. After reverse...

Genome-wide transcriptome analysis of the salt stress tolerance mechanism in Rosa chinensis

, Guixia Jia. Data curation: Xiaoming Tian, Huacong Ci, Pengshan Wang, Lu Yu, Guixia Jia. Formal analysis: Xiaoming Tian, Huacong Ci, Pengshan Wang, Lu Yu, Guixia Jia. Investigation: Xiaoming Tian

Testing Longitudinal Relationships between Internet Addiction and Well-Being in Hong Kong Adolescents: Cross-Lagged Analyses Based on three Waves of Data

Using a panel design, this study examined the prospective relationships between Internet addiction and life satisfaction as well as hopelessness in a representative sample of Hong Kong adolescents. Starting from 2009/10 academic year, 3328 Secondary 1 students in 28 secondary schools in Hong Kong participated in this longitudinal study (Mean age = 12.59 years; SD = 0.74 years...

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A

A GGGGCC hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense repeat-containing transcripts undergo repeat-associated non-AUG-initiated translation to produce five dipeptide proteins (DPRs). The polyGR and polyPR DPRs are extremely toxic when expressed in...

Evaluation of “Colorful Life”: A Multi-Addiction Expressive Arts Intervention Program for Adolescents of Addicted Parents and Parents with Addiction

This study evaluated an expressive arts intervention program (“Colorful Life”) for adolescents with addicted parents and parents with addiction in Hong Kong. Different evaluation strategies were employed. Objective outcome evaluation adopting a one group pretest-posttest design showed positive changes in adolescents’ (N = 43) beliefs about addiction. Both adolescents’ and parents...

Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis

Receptor-interacting kinase-3 (RIP3) is a key regulator of necroptosis. It has been shown that the expression of RIP3 is silenced in most cancer cells and tissues due to genomic methylation. However, the regulatory mechanisms controlling RIP3 expression in cancer cells have not been fully elucidated. Here, we report that Sp1, a well-characterized zinc-finger transcription factor...

Differential Expression of Serum Proteins in Rats with Allergic Asthma: A Study Based on the Nanoliter Two-Dimensional Liquid Chromatography Technique

Objective. To investigate the pathogenesis of allergic asthma via the nanoliter two-dimensional liquid chromatography (nano-2D-LC) technique. Method. 24 Wistar rats were randomized into 3 groups: the blank-control group (A), the restrained group (B), and the asthma model group (C). The nanoliter two-dimensional liquid chromatography (nano-2D-LC) technique was used to study the...

Distribution behavior of superparamagnetic carbon nanotubes in an aqueous system

This study investigates the distribution behavior of superparamagnetic multiwalled carbon nanotubes (SPM-MWCNTs) in an aqueous system containing Lake Tai sediment. Specifically, the effects of dissolved organic matter (DOM) and sediment on SPM-MWCNTs under various conditions and the interaction forms between them were evaluated through a modified mathematical model and...

Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells

MYST histone acetyltransferases have crucial functions in transcription, replication and DNA repair and are hence implicated in development and cancer. Here we characterise Myst2/Kat7/Hbo1 protein interactions in mouse embryonic stem cells by affinity purification coupled to mass spectrometry. This study confirms that in embryonic stem cells Myst2 is part of H3 and H4 histone...

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro Yunlong Wang,1,* Yuling Luo,1,* Chunhong Li,1 Xiaoqin Zhang,1 Chao Pi,1 Lu Yu,2

An Xp11.2 translocation renal cell carcinoma with SMARCB1 (INI1) inactivation in adult end-stage renal disease: a case report

Background Xp11.2 translocation/transcription factor E3 (TFE3) rearrangement renal cell carcinoma (RCC) is a rare subtype of RCC with limited clinical and pathological data. Case presentation Here we present an unusual high-grade Xp11.2 translocation RCC with a rhabdoid feature and SMARCB1 (INI1) inactivation in a 40-year-old man with end-stage kidney disease. The histological...

A 4-year Longitudinal Study of Well-being of Chinese University Students in Hong Kong

The present longitudinal study explored the development of personal well-being in university students over 4 years. Personal well-being was indexed by multiple indicators including life satisfaction, positive youth development qualities, and university engagement. A sample of 434 students enrolled in the new 4-year undergraduate program in one university in Hong Kong was...

Efficacy and safety of paliperidone palmitate three-monthly formulation in East Asian patients with schizophrenia: subgroup analysis of a global, randomized, double-blind, Phase III, noninferiority study

study Adam J Savitz,1 Haiyan Xu,2 Srihari Gopal,1 Isaac Nuamah,2 Paulien Ravenstijn,3 David Hough,1 Maju Mathews,4 Yu Feng,5 Lu Yu,6 Masayoshi Takahashi,7 Dennis Liu,8 Gang Wang,9 Jin-Sang Yoon,10 Jiahn