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32 papers found.
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Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer

Research (A*STAR), Biopolis, Singapore, SingaporeHeng Liang Tan, Charlene Yong, Bao Zhu Tan, Wey Jia Fong, Jayanthi Padmanabhan, Angela Chin, Vanessa Ding, Ally Lau, Lu Zheng, Xuezhi Bi, Yuansheng Yang ... Research journals • PubMed • Google Scholar Search for Lu Zheng in:Nature Research journals • PubMed • Google Scholar Search for Xuezhi Bi in:Nature Research journals • PubMed • Google Scholar Search for

Teng-Long-Bu-Zhong-Tang induces p21-dependent cell senescence in colorectal carcinoma LS174T cells via histone acetylation

Teng-Long-Bu-Zhong-Tang induces p21-dependent cell senescence in colorectal carcinoma LS174T cells via histone acetylation Bing Hu,1,2 Hong-Mei An,3 Shuang-Shuang Wang,1,2 Jia-Lu Zheng,1,2 Xia Yan

Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer

Background The receptor for advanced glycation endproducts (RAGE) and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial cancer remains largely unknown. Methods RAGE expression and microvessel density were examined in 20 cases of normal endometrial tissue, 37 cases of well...

Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Insulin Resistance Partly via the Y5 Receptor

Intracerebroventricular injection and overexpression of Neuropeptide Y (NPY) in the paraventricular nucleus (PVN) has been shown to induce obesity and glucose metabolism disorder in rodents; however, the underlying mechanisms are still unclear. The aim of this study was to investigate the mechanism contributing to glucose metabolic disturbance induced by NPY. Recombinant...

Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion

Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures that the interphase centrosome(s) function as a single microtubule-organizing center. Impairment of centrosome cohesion leads to the splitting of centrosomes. Although the list of cohesion proteins is growing, the precise composition and regulation of centrosome cohesion are still...

Muscular strength measurements indicate bone mineral density loss in postmenopausal women

Muscular strength measurements indicate bone mineral density loss in postmenopausal women Zhixiong Zhou,1,2 Lu Zheng,3 Dengyun Wei,4 Ming Ye,3 Xun Li2 1School of Physical Education and Coaching ... , Beijing, People's republic of China 1 g raduate s chool, Beijing s port University , Beijing, People's republic of China 2 lu Zheng school of Kinesiology and health education, Capital University of Physical

Fabrication of hierarchical polycaprolactone/gel scaffolds via combined 3D bioprinting and electrospinning for tissue engineering

It is a severe challenge to construct 3D scaffolds which hold controllable pore structure and similar morphology of the natural extracellular matrix (ECM). In this study, a compound technology is proposed by combining the 3D bioprinting and electrospinning process to fabricate 3D scaffolds, which are composed by orthogonal array gel microfibers in a grid-like arrangement and...

GIS-based numerical modelling of debris flow motion across three-dimensional terrain

The objective of this study is to incorporate a numerical model with GIS to simulate the movement, erosion and deposition of debris flow across the three dimensional complex terrain. In light of the importance of erosion and deposition processes during debris flow movement, no entrainment assumption is unreasonable. The numerical model considering these processes is used for...

Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?

Introduction Sleep deprivation is common in critically ill patients in the intensive care unit (ICU). Noise and light in the ICU and the reduction in plasma melatonin play the essential roles. The aim of this study was to determine the effect of simulated ICU noise and light on nocturnal sleep quality, and compare the effectiveness of melatonin and earplugs and eye masks on sleep...

DFA7, a New Method to Distinguish between Intron-Containing and Intronless Genes

Intron-containing and intronless genes have different biological properties and statistical characteristics. Here we propose a new computational method to distinguish between intron-containing and intronless gene sequences. Seven feature parameters , , , , , , and based on detrended fluctuation analysis (DFA) are fully used, and thus we can compute a 7-dimensional feature vector...

Expression changes of ribosomal proteins in phosphate- and iron-deficient Arabidopsis roots predict stress-specific alterations in ribosome composition

Background Ribosomes are essential ribonucleoprotein complexes that are engaged in translation and thus indispensable for growth. Arabidopsis thaliana ribosomes are composed of 80 distinct ribosomal proteins (RPs), each of which is encoded by two to seven highly similar paralogous genes. Little information is available on how RP genes respond to a shortage of essential mineral...

Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells

Background microRNA-122 (miR-122) is the most abundant and specific miRNA in the liver. It acts as an important tumor suppressor in hepatocellular carcinoma (HCC) through regulating its target genes, but details of its own regulation are largely unknown. Farnesoid X receptor (FXR), a transcription factor with multiple functions, plays an important role in protecting against liver...

Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Translocation of a nascent protein from the cytosol into the ER mediated by its signal peptide is a critical step in protein secretion. The aim of this work was to develop a platform technology to optimize the signal peptides for high level production of therapeutic antibodies in CHO cells. A database of signal peptides from a large number of human immunoglobulin (Ig) heavy chain...

Intralipid Decreases Apolipoprotein M Levels and Insulin Sensitivity in Rats

Background Apolipoprotein M (ApoM) is a constituent of high-density lipoproteins (HDL). It plays a crucial role in HDL-mediated reverse cholesterol transport. Insulin resistance is associated with decreased ApoM levels. Aims To assess the effects of increased free fatty acids (FFAs) levels after short-term Intralipid infusion on insulin sensitivity and hepatic ApoM gene...

Prediction of Protein Modification Sites of Pyrrolidone Carboxylic Acid Using mRMR Feature Selection and Analysis

Pyrrolidone carboxylic acid (PCA) is formed during a common post-translational modification (PTM) of extracellular and multi-pass membrane proteins. In this study, we developed a new predictor to predict the modification sites of PCA based on maximum relevance minimum redundancy (mRMR) and incremental feature selection (IFS). We incorporated 727 features that belonged to 7 kinds...

ShRNA-Targeted COMMD7 Suppresses Hepatocellular Carcinoma Growth

Background COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) and associated with tumor invasion and poor prognosis. We aim to examine the biological function of COMMD7 in HCC by shRNA silencing. Methods COMMD7 expressions were examined in human HCC cell lines HepG2, Huh7, Hep3B, HLE, HLF, SK-Hep-1 and PLC/PRF/5 cells. Recombinant pGenesil-COMMD7...

Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease

Background There is accumulating evidence that oxidative stress plays an important role in the pathophysiology of chronic obstructive pulmonary disease (COPD). One current hypothesis is that the increased oxidant burden in these patients is not adequately counterbalanced by the lung antioxidant systems. Objective To determine the levels of oxidised human serum albumin (HSA) in...

Role of Metabolic Factors in the Association Between Osteocalcin and Testosterone in Chinese Men

Osteocalcin can regulate energy metabolism and increase testosterone production. Although previous studies have shown the positive association between osteocalcin and testosterone, the effect of metabolic factors in the association is unclear.