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Polymorphism of the Fractalkine Receptor CX3CR1 and Systemic Sclerosis-associated Pulmonary Arterial Hypertension

Fractalkine (FKN) and its receptor CX3CR1 are critical mediators in the vascular and tissue damage of several chronic diseases, including systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH). Interestingly, the V249I and T280M genetic polymorphisms influence CX3CR1 expression and function. We investigated whether these polymorphisms are associated with PAH secondary...

Polymorphism of the Fractalkine Receptor CX3CR1 and Systemic Sclerosis-associated Pulmonary Arterial Hypertension

Fractalkine (FKN) and its receptor CX3CR1 are critical mediators in the vascular and tissue damage of several chronic diseases, including systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH). Interestingly, the V249I and T280M genetic polymorphisms influence CX3CR1 expression and function. We investigated whether these polymorphisms are associated with PAH secondary...

Impact of the M184V Resistance Mutation on Virological Efficacy and Durability of Lamivudine-Based Dual Antiretroviral Regimens as Maintenance Therapy in Individuals With Suppressed HIV-1 RNA: A Cohort Study

?Prima Divisione Malattie Infettive Ospedale L.? Sacco); Maria Rita Gismondo (MILANO?Laboratorio Microbiologia Ospedale L.? Sacco [Dipart. Scienze Cliniche, Sez. Malattie Infettive]); Maria Luisa Biondi

Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients

Background. Vascular calcification and accelerated atherosclerosis are major causes of death in haemodialysis (HD) patients. Matrix metalloproteinases (MMPs) are a family of enzymes, involved in the biology of extracellular matrix and in atherogenesis. MMP1 and MMP3 contribute to the enlargement and instability of atherosclerotic plaque, respectively. The common polymorphisms on...

PPAR-γ2 Pro12Ala Variant, Insulin Resistance and Plasma Long-chain Polyunsaturated Fatty Acids in Childhood Obesity

Milan, ItalyGiovanni RadaelliDepartment of Clinical Chemistry and Microbiology, San Paolo Hospital; University of Milan, I-20142 Milan, ItalyMaria Luisa Biondi AuthorsSearch for Silvia Scaglioni in:Nature ... ScholarSearch for Maria Luisa Biondi in:Nature Research journals • PubMed • Google ScholarSearch for Giovanni Radaelli in:Nature Research journals • PubMed • Google ScholarSearch for Carlo Agostoni in:Nature