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Search: authors:"Mónica Bequet-Romero"

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Does VEGF-targeted active immunotherapy induce complete abrogation of platelet VEGF levels?

Vascular endothelial growth factor (VEGF) is involved in physiological angiogenesis, but also is considered one of the key factors that promotes tumor angiogenesis. CIGB-247 is a VEGF-based vaccine that has been evaluated in phase I clinical trial patients with advanced solid tumors. This specific active immunotherapy is able to reduce platelet VEGF levels; however it is unknown...

Expression, purification and characterization of a recombinant fusion protein based on the human papillomavirus-16 E7 antigen

A fusion protein comprising a cell penetrating and immunostimulatory peptide corresponding to residues 32 to 51 of the Limulus polyphemus protein linked to human papillomavirus (HPV)-16 E7 antigen (LALF32-51-E7) was expressed in E. coli BL21 (DE3) cells. The recombinant protein in E. coli accounted for approximately 18% of the total cellular protein and purified with a single...

Mutated variant of human vascular endothelial growth factor as a vaccine candidate for cancer immunotherapy

protein. Biotechnol  Appl Biochem 2006;44:45-53.   *This work received the Award of the National Academy of Sciences of Cuba for the year 2008.   Mónica Bequet-Romero. Recombinant Antibodies

Transgenic plants of Nicotiana tabacum L. express aglycosylated monoclonal antibody with antitumor activity

The expression and production of pharmaceutical, industrial and veterinary proteins in plants is an attractive approach. These expression hosts bear an enormous production potential in terms of volume, easy processing of the starting material, and safety of the final product due to the lack of pathogens able to infect animal and human cells. Antibodies are among the most...

Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner

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