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Search: authors:"M. A. Witlox"

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Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

Netherlands 1 M. A. Witlox Department of Orthopaedic Surgery , Westfries Gasthuis, Hoorn, The Netherlands 2 J. PosthumaDeBoer B. J. van Royen (&) Department of Orthopaedic Surgery, VU University Medical Center

Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdΔ24

, The NetherlandsD Oosterhoff, H M Pinedo, M A Witlox, J E Carette, W R Gerritsen & V W van Beusechem AuthorsSearch for D Oosterhoff in:Nature Research journals • PubMed • Google Scholar Search for H M ... Pinedo in:Nature Research journals • PubMed • Google Scholar Search for M A Witlox in:Nature Research journals • PubMed • Google Scholar Search for J E Carette in:Nature Research journals • PubMed

Different susceptibility of osteosarcoma cell lines and primary cells to treatment with oncolytic adenovirus and doxorubicin or cisplatin

Despite improvements in treatment regimens for osteosarcoma (OS) patients, survival rate has not increased over the last two decades. New treatment modalities are therefore warranted. Preclinical results with conditionally replicative adenoviruses (CRAds) to treat OS are promising. One type of CRAd that was effective against OS cells is Ad5-Δ24RGD. In other types of cancer, CRAds...