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Search: authors:"M. A. Yorek"

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Effect of Fidarestat and α-Lipoic Acid on Diabetes-Induced Epineurial Arteriole Vascular Dysfunction

In the present study, the authors examined whether treating streptozotocin-induced diabetic rats with the combination of α-lipoic acid and fidarestat, an aldose reductase inhibitor, can promote the formation of dihydrolipoic acid in diabetic animals and thereby enhance the efficacy of α-lipoic acid as monotherapy toward preventing diabetic vascular and neural dysfunction.Treating...

Effect of Fidarestat and α-Lipoic Acid on Diabetes-Induced Epineurial Arteriole Vascular Dysfunction

In the present study, the authors examined whether treating streptozotocin-induced diabetic rats with the combination of α-lipoic acid and fidarestat, an aldose reductase inhibitor, can promote the formation of dihydrolipoic acid in diabetic animals and thereby enhance the efficacy of α-lipoic acid as monotherapy toward preventing diabetic vascular and neural dysfunction.Treating...

Effect of Fidarestat and α-Lipoic Acid on Diabetes-Induced Epineurial Arteriole Vascular Dysfunction

In the present study, the authors examined whether treating streptozotocin-induced diabetic rats with the combination of α-lipoic acid and fidarestat, an aldose reductase inhibitor, can promote the formation of dihydrolipoic acid in diabetic animals and thereby enhance the efficacy of α-lipoic acid as monotherapy toward preventing diabetic vascular and neural dysfunction.Treating...

A comparison of diabetic polyneuropathy in Type II diabetic BBZDR/Wor rats and in Type I diabetic BB/Wor rats

Aims/hypothesis. To examine the functional, metabolic and structural abnormalities in peripheral nerve in the spontaneously Type II (non-insulin-dependent) diabetic BBZDR/Wor rat and compare these data with those in the Type I (insulin-dependent) diabetic BB/Wor rat.¶Methods. Animals were examined at 6 and 14 months of diabetes. Nerve conduction velocity was measured...