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Ultrasonic Investigation of Molecular Interactions in Binary Mixtures at 303 K

The ultrasonic velocity, density and viscosity at 303 K have been measured in the binary systems of toluene with benzene and o-xylone with benzene. The acoustical parameters such as adiabatic compressibility, free length, free volume and acoustical impedance are calculated. The results are interpreted in terms of molecular interaction between the components of the mixtures

Effects of Single Nucleotide Polymorphisms on Human N-Acetyltransferase 2 Structure and Dynamics by Molecular Dynamics Simulation

Background Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. This enzyme is highly polymorphic in different human populations. Several polymorphisms of NAT2, including the single amino acid substitutions R64Q, I114T, D122N, L137F, Q145P, R197Q, and G286E, are classified as slow...

Endodontic Management of Mandibular First Molar with Middle Distal Canal: A Case Report

Cirugía Bucal, vol. 12, no. 8, pp. E605–E609, 2007. View at Google Scholar · View at ScopusS. S. Chandra, M. Rajasekaran, P. Shankar, and R. Indira, “Endodontic management of a mandibular first molar with

Endodontic Management of Mandibular First Molar with Middle Distal Canal: A Case Report

Cirugía Bucal, vol. 12, no. 8, pp. E605–E609, 2007. View at Google Scholar · View at ScopusS. S. Chandra, M. Rajasekaran, P. Shankar, and R. Indira, “Endodontic management of a mandibular first molar with

An effective approach for generating a three-Cys2His2 zinc-finger-DNA complex model by docking

Background Determination of protein-DNA complex structures with both NMR and X-ray crystallography remains challenging in many cases. High Ambiguity-Driven DOCKing (HADDOCK) is an information-driven docking program that has been used to successfully model many protein-DNA complexes. However, a protein-DNA complex model whereby the protein wraps around DNA has not been reported...

Lesser Known Ethnomedicinal Plants of Alagar Hills, Madurai District of Tamil Nadu, India

The ethnobotanical uses of plant species viz. Embelia basal (Roxb.) DC., Gymnema lactiferum R.Br., Ophiorrhiza mungos L., and Syzygium alternifolium (Wight) Walp. were recorded from Alagar hills of Madurai district, Tamil Nadu.

Lesser Known Ethnomedicinal Plants of Alagar Hills, Madurai District of Tamil Nadu, India

The ethnobotanical uses of plant species viz. Embelia basal (Roxb.) DC., Gymnema lactiferum R.Br., Ophiorrhiza mungos L., and Syzygium alternifolium (Wight) Walp. were recorded from Alagar hills of Madurai district, Tamil Nadu.

Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae

Klebsiella pneumoniae PmrA is a polymyxin-resistance-associated response regulator. The C-terminal effector/DNA-binding domain of PmrA (PmrAC) recognizes tandem imperfect repeat sequences on the promoters of genes to induce antimicrobial peptide resistance after phosphorylation and dimerization of its N-terminal receiver domain (PmrAN). However, structural information concerning...

Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation

Trichomonas vaginalis Myb3 transcription factor (tvMyb3) recognizes the MRE-1 promoter sequence and regulates ap65-1 gene, which encodes a hydrogenosomal malic enzyme that may play a role in the cytoadherence of the parasite. Here, we identified tvMyb353–180 as the essential fragment for DNA recognition and report the crystal structure of tvMyb353–180 bound to MRE-1 DNA. The N...

NMR structural analysis of DNA recognition by a novel Myb1 DNA-binding domain in the protozoan parasite Trichomonas vaginalis

The transcription regulator, tvMyb1, is the first Myb family protein identified in Trichomonas vaginalis. Using an electrophoretic mobility shift assay, we defined the amino-acid sequence from Lys35 to Ser141 (tvMyb135–141) as the minimal DNA-binding domain, encompassing two Myb-like DNA-binding motifs (designated as R2 and R3 motifs) and an extension of 10 residues at the C...

Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats

To evaluate the association between hypertension, male erectile function, Rho-kinase, and cyclic GMP pathways, we monitored neurogenic erectile response in spontaneously hypertensive (SHR) vs normotensive rats. We also evaluated SHR erectile function before and after intracavernosal injection of either the specific Rho-kinase inhibitor Y-27632 or a combination of Y-27632 and the...