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Adaptation and validation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for the Netherlands

interest M. Wapenaar, J. Twiss, M. Wagenaar, P. Seijkens, L. van den Toorn, J. Stepanous, A. Heaney, A. van den Bosch and K. A. Boomars state that there are no conflicts of interest. Open Access This article

Expression patterns of protein C inhibitor in mouse development

, Austria 1 G. T. M. Wagenaar J. C. M. Meijers Department of Clinical Chemistry and Haematology, University Medical Center , Utrecht, The Netherlands 2 G. T. M. Wagenaar Department of Pediatrics, Division of

Preventive youth health care in 11 European countries: an exploratory analysis

of Twente , P.O.Box 215, 7500, AE, Enschede, The Netherlands 4 M. M. Wagenaar-Fischer TNO, Leiden, The Netherlands 5 B. C. Carmiggelt Dutch Child Health Knowledge Center , Utrecht, The Netherlands 6 BE

The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice

Background Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation, airways obstruction and emphysema, and is a risk factor for cardiovascular disease (CVD). However, the contribution of these individual COPD components to this increased risk is unknown. Therefore, the aim of this study was to determine the contribution of emphysema in the presence...

Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

Background Cigarette smoking induces inflammatory responses in all smokers and is the major risk factor for lung disease such as chronic obstructive pulmonary disease (COPD). In this progressive disease, chronic inflammation in the lung contributes to lung tissue destruction leading to the formation of chemotactic collagen fragments such as N-acetylated Proline-Glycine-Proline (N...

Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection

Background. Acute pyelonephritis is one of the most common bacterial infections. Tissue-type plasminogen activator (tPA) is a potent fibrinolytic agent, but can play a role in inflammatory processes as well. Methods. We induced pyelonephritis in tPA−/− and C57BL/6 wild-type (WT) mice by intravesical inoculation with 1010 CFU uropathogenic Escherichia coli 1677. The mice were...