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Long-term Clinical Outcome and MIBI SPECT Parameters in Percutaneous Coronary Interventions

Background and Aim Primary percutaneous coronary intervention (PCI) is the preferred treatment option for acute myocardial infarction (MI). Off-site PCI reduces time-to-treatment, which could potentially lead to enhanced clinical outcomes. Therefore, we investigated whether off-site PCI improves 5-year clinical outcomes compared with on-site PCI and whether this is related to in...

Dynamics in chimerism of T cells and dendritic cells in relapsed CML patients and the influence on the induction of alloreactivity following donor lymphocyte infusion

Donor lymphocyte infusion (DLI) after allogeneic SCT induces complete remissions in approximately 80% of patients with relapsed CML in chronic phase, but some patients do not respond to DLI. We studied absolute numbers of dendritic cell (DC) subsets and chimerism in T cells and two subsets of blood DCs (myeloid DCs (MDCs) and plasmacytoid DCs (PDCs)) in relation to DLI-induced...

Intensive induction chemotherapy with C-BOP/BEP for intermediate- and poor-risk metastatic germ cell tumours (EORTC trial 30948)

haematopoietic support in poor risk non-seminomatous germ-cell tumours: an effective first-line therapy with minimal toxicity. Ann Oncol 11: 427–434 CASPubMedArticleGoogle Scholar De Wit R, Louwerens M, de Mulder ... in:Nature Research journals • PubMed • Google ScholarSearch for G Kaiser in:Nature Research journals • PubMed • Google ScholarSearch for P H M de Mulder in:Nature Research journals • PubMed • Google

Phase II EORTC trial with 5-fluorouracil, cisplatin and interferon-α as second-line treatment of advanced transitional cell cancer of the urothelial tract

Background Based on the favorable results of the combination 5-fluorouracil (5-FU), cisplatin and interferon-α as second-line treatment in advanced metastatic transitional-cell carcinoma of the urothelial tract a confirmatory study was executed in a multicenter setting. Patients and methods In this open label phase II study 43 patients failing adequate previous chemotherapy were...

Coincidence of seminoma and sarcoidosis: A myth or fact?

A patient with a stage II seminoma of the testis was treated with a routine orchidectomy and irradiation. One and a half years later enlarged mediastinal lymph nodes were noted. Additional staging showed no other abnormalities and a media-stinoscopy was performed. The initial histologic examination confirmed the clinically suspected diagnosis of sarcoidosis. However, additional...

Randomized study of a short course of weekly cisplatin with or without amifostine in advanced head and neck cancer

Background: Cisplatin is one of the most active cytotoxic agents available for the treatment of patients with head and neck cancer. In a previous phase II study with weekly administration of cisplatin, a response rate of 51% was achieved. However, only in a minority of the patients the planned high dose intensity of 80 mg/m2/week could be reached because of toxicity, mainly...

A multi-center prospective phase II study of high-dose chemotherapy in germ-cell cancer patients relapsing from complete remission

Purpose: To prospectively determine the efficacy of repeated high-dose alkylating chemotherapy to salvage patients with germ-cell tumors who relapsed after adequate first-line chemotherapy. Patients and methods: Patients with germ-cell cancers relapsing from a first, second or third complete remission induced by chemotherapy were offered to participate in a Dutch national...

Phase II study on mitoxantrone in adenoid cystic carcinomas of the head and neck

J. Verweij 2 7 P. H. M de Mulder 1 7 A. de Graeff 0 7 J. B. Vermorken 7 J. Wildiers 5 7 J. Kerger 4 7 J. Schornagel 3 7 F. Cognetti 7 A. Kirkpatrick 7 T. Sahmoud 7 J. L. Lefebvre 7 on behalf of the

Impact of the Treating Institution on Survival of Patients With “ Poor-Prognosis” Metastatic Nonseminoma

.; R. de Wit, Rotterdam Cancer Institute and University Hospital, The Neth- erlands; P. H. M. de Mulder, Sint Radboud University Hospital , Nijmegen , The Netherlands; S. B. Kaye, Western Infirmary

European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG)

H. J. Schmoll 0 R. Souchon S. Krege P. Albers J. Beyer C. Kollmannsberger S. D. Fossa N. E. Skakkebaek R. de Wit K. Fizazi J. P. Droz G. Pizzocaro G. Daugaard P. H. M. de Mulder A. Horwich T. Oliver